Leveraging implementation science theories to develop and expand the use of a penicillin allergy de-labeling intervention.

Background: Penicillin allergy is the most frequently reported drug allergy, yet most patients can tolerate the drug if challenged. Despite this discrepancy, large scale penicillin allergy de-labeling interventions have not been widely implemented in many health care systems. The application of a multi-method implementation science approach can provide key tools to study this evidence to practice gap and provide insight to successfully operationalize penicillin allergy evaluation in real-world clinical settings.

Barriers to penicillin allergy de-labeling in the inpatient and outpatient settings: a qualitative study.

Background: Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of labels are incorrect, scalable interventions are not well established. As part of a larger mixed methods investigation, we conducted a qualitative study to describe the barriers to implementing a risk-based penicillin de-labeling protocol within a single site Veteran's hospital.

Dose-response research in digital health interventions: Concepts, considerations, and challenges.

To optimize digital health interventions, intervention creators must determine what intervention dose will produce the most substantial health behavior change-the dose-response relationship-while minimizing harms or burden. In this article we present important concepts, considerations, and challenges in studying dose-response relationships in digital health interventions. We propose that interventions make three types of prescriptions: (1) , prescriptions to receive content from the intervention, such as to read text or listen to audio; (2) , prescriptions to produce and provide content to the intervention, such as to send text messages or post intervention-requested photos on social media; and (3) , prescriptions to engage in behaviors outside the intervention, such as changing food intake or meditating.

Invisible partners in care: Snapshot of well-being among caregivers receiving comprehensive support from Veterans Affairs.

Background And Aims: Since May 2011, over 23 000 caregivers of Veterans seriously injured on or after September 11, 2001 have enrolled in the Program of Comprehensive Assistance for Family Caregivers (PCAFC). PCAFC provides caregivers training, a stipend, and access to health care. The aim of this study is to describe the characteristics of caregivers in PCAFC and examine associations between caregiver characteristics and caregiver well-being outcomes.