492 results match your criteria: "William Harvey Hospital[Affiliation]"

Background:  Femoral neck fractures in elderly individuals cause significant morbidity, and their management is particularly challenging in rural areas where healthcare access is limited. The recommended treatment for displaced femoral neck fractures in elderly patients with poor mobility, cognitive dysfunction and multiple comorbidities is a hemiarthroplasty, which can be performed with various implants, including monopolar implants like Austin Moore prosthesis (AMP) and bipolar prosthesis (BP). In developing countries like India, rural areas often have constraints with healthcare resources.

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Hypertonic saline in acute decompensated heart failure (HSHF).

Indian Heart J

December 2024

Division of Epidemiology, Biostatistics and Population Health, St. John's Research Institute, Bangalore, India.

Hypertonic saline with high dose furosemide improves refractory heart failure. In this case series of 10 patients of refractory acute decompensated heart failure, effect of HSS with furosemide was compared with furosemide alone. Patients responded to the therapy better, with faster decongestion, without significant adverse effects or worsening renal function.

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Objective: The objective of this study was to report the 12-month oncological outcomes for patients with non-muscle-invasive bladder cancer (NMIBC) within the prospective, international COVIDSurg Cancer study.

Patients And Methods: Eligible patients were aged ≥18 years and scheduled for elective surgical management of NMIBC with curative intent (transurethral resection of bladder tumour [TURBT] or bladder biopsy) from 21 January to 14 April 2020. The primary outcome was disease recurrence within 12 months of previous elective TURBT/bladder biopsy.

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Background Distal radius fractures (DRFs) are commonly treated with percutaneous K-wire or plate fixation. The relative efficacy and stability of these methods, particularly in osteoporotic patients and in cases involving both distal radius and ulna fractures, remain subjects of clinical debate. Objective This study aims to compare the outcomes of percutaneous K-wire fixation versus plate fixation in patients with distal end radius fractures, focusing on postoperative stability in osteoporotic conditions and both-bone distal end fractures.

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Purpose: To comprehensively review the literature about numerical aberrations of the orbital muscles of ocular motility (here referred to as extraocular muscles [EOMs]) and the levator palpebrae superioris (LPS).

Methods: The authors summarize the embryologic bases and the possible etiopathogenetic causes of numerical aberrations of the EOMs and the LPS and organize these lesions into several broad categories. The clinical and radiologic diagnostic challenges are discussed.

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We hope to add to the literature evidence regarding the increasing morbidity associated with an invasive infection by a normal body commensal,  (). An increasing amount of literature documentation of intra- and extracranial disease manifestations following a systemic infection by this micro-organism is noted. We describe the findings of severe, necrotizing right lung disease and possible septic brain emboli in a 54-year-old gentleman in whom microbiological investigations suggest , and mixed anaerobes as possible culprit micro-organisms causing his severe disease state.

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Objective: To investigate the prevalence of, and relationship between, bullying and malocclusion in schoolchildren aged 10-14 years in the South East of the UK.

Design: Cross-sectional cohort study.

Setting: Sixteen primary and secondary schools in South East of the UK.

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Sternal fractures are associated with significant morbidity and mortality, with some patients requiring admission for pain management, often through systemic analgesia, which may be ineffective. Regional anaesthetic techniques are more challenging for sternal fractures than rib fractures and require experienced clinicians. Local anaesthetic techniques are becoming recognised as a modality to improve pain control and to reduce complications from opioid use, especially in the elderly.

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Article Synopsis
  • * A case is reported of a man in his fifties who showcased incidental HU and was diagnosed with insulinoma after a series of medical evaluations, including biochemical and radiologic studies.
  • * The authors emphasize the need for more research to better understand the link between HU and insulinoma, as well as to develop protocols for detecting patients with this condition.
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  • Echocardiography is recommended as a primary diagnostic tool for patients in shock, but its implementation in critical care is inconsistent and not well defined.
  • A study involving 178 critical care units in the UK tracked 1015 patients, revealing that 54% received an echocardiogram, which helped clarify diagnoses or change treatment plans in over half of the cases.
  • Despite its benefits, only 25% of echocardiograms complied with national governance guidelines, indicating a need for improved usage and adherence in future practices.
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  • - The study aimed to assess the safety and potential effectiveness of injecting cord blood platelet-rich plasma (CB-PRP) into the eyes of patients suffering from geographic atrophy linked to dry age-related macular degeneration (d-AMD).
  • - Thirteen patients participated, with one eye receiving the treatment and the other serving as a control, and outcomes were evaluated over 12 months through various visual and imaging assessments.
  • - Results indicated a slight improvement in visual acuity for the treated eyes compared to controls, but the atrophic area increased in both groups and there were no significant complications reported from the procedure.
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Creating Novel Standards for Datapoints on an Elective Orthopaedic Theatre List Document.

Malays Orthop J

July 2024

Department of Trauma and Orthopaedics, William Harvey Hospital, Ashford, United Kingdom.

Introduction: Orthopaedic theatre lists are an important tool which must convey essential information to all staff to run an effective and safe theatre list. However, there are no set standards or guidelines on the components of an Orthopaedic theatre list. The objective of this study is to formulate guidelines for elective Orthopaedic theatre lists which improve efficiency and reduce errors.

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Introduction The impact of the current economic and environmental climate, both nationally and globally, is further straining the NHS. This has led to scrutiny of high-expenditure areas, including consumables. Clinician's knowledge surrounding health economics is sparse, and we conducted this survey to assess cost-awareness within the Trauma and Orthopaedic (T&O) departmental staff.

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A description of an acute hospital presentation with severe tachyarrhythmia requiring multiple direct current cardioversions in a 45-year-old male bodybuilder with underlying cardiomyopathy possibly caused by long-term anabolic steroid abuse and more recent thyroxine misuse is described. A review of the literature regarding the above associations was also done. This case report further adds to the literature regarding the harmful effect of androgenic anabolic steroid misuse (with the added effect of thyroxine misuse in this case) on the heart.

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A case of a late-onset Rasmussen's encephalitis (RE) presenting with drug-refractory focal epilepsy and progressive hemispheric cerebral atrophy noted on a serial radiologic head scan done on a gentleman in his 30s is presented. A positive antinuclear ribonucleoprotein antibody test, a weak-positive antinuclear antibody test, an elevated C3 complement, and possible trauma were identified as potential causative or promoting factors for RE in this patient. Literature evidence regarding the challenges with the aetiopathogenesis description, diagnosis, and management of this rare condition has been reviewed in this article.

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Article Synopsis
  • - This study assessed the effectiveness of bone anchored maxillary protraction (BAMP) in treating class III skeletal malocclusion in children (ages 11-14) compared to a control group receiving no treatment, focusing on surgery necessity, dental changes, and psychological effects.
  • - Conducted as a randomized controlled trial in six UK hospitals, 57 participants were divided into two groups: 28 received BAMP treatment, while 29 were in the no-treatment control group; measurements were taken at multiple points over 3 years.
  • - Results showed significant improvements in skeletal and dental measures for the BAMP group at the 18-month mark, with a lower percentage of participants in this group feeling they needed surgery at the 3-year
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Aim: To investigate the efficacy and safety profile of T-shaped pars plana scleral incision technique in removing large intraocular foreign bodies, during 23-gauge pars plana vitrectomy.

Methods: Retrospective interventional case series that included patients diagnosed with a large intraocular foreign body (IOFB). Possible postoperative complications were recorded 24 h, 1 month, 3 and 6 months postoperatively.

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Metformin mitigates dementia risk among individuals with type 2 diabetes.

Clin Diabetes Endocrinol

May 2024

Department of Allied and Public Health, School of Health, Sport and Bioscience, University of East London, London, UK.

This mini-narrative review explores the relationship between diabetes and dementia, focusing on the potential mitigating role of metformin in reducing cognitive decline among individuals with type 2 diabetes. The interplay of factors such as glycemic control, diabetic complications, and lifestyle influences characterises diabetes-related dementia. This review emphasises the significance of comprehensive diabetes management in addressing the heightened risk of dementia in this population.

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Background Ankle fractures are very common injuries seen in an emergency setting. Initial management involves the application of below-knee plaster casts. At our local trauma meetings, we have observed that below-knee casts are often applied incorrectly which can result in suboptimal outcomes for patients and increase the burden on plaster room services if re-application is required.

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This article aims to review available literature evidence about the harmful effects of long-term anabolic-androgenic steroid (AAS) abuse on the heart. A review of 11 existing literature articles regarding this association has been used in the development of this review article. There is increasing medical literature documentation of the eventual harmful effect of AAS misuse or abuse on the heart.

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This case report presents a description of a hypertrophic left ventricle with reduced ejection fraction in a man in his mid-twenties with clinical, radiologic, and biochemical features of a rare syndrome called mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). A literature review of this uncommon syndrome and MELAS cardiomyopathy has been conducted.

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Background: The aim of this study was to demonstrate the impact of laparoscopic cholecystectomy on the physical and mental health of patients with gallbladder dysmotility.

Methods: Retrospective data was collected from 314 patients who had undergone a hepatobiliary iminodiacetic acid (HIDA) scan between June 2012 and June 2022 in a District General Hospital in South East England. Sixty-three patients who were diagnosed with gallbladder dysmotility were then contacted and asked to participate in a telephone interview regarding their symptoms.

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