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Antibacterial activity of Azanza garckeana extracts (Malvaceae) in vitro and their potential use in respiratory infections.
Microb Pathog
January 2025
Department of Therapeutics, Natural Products Unit, African Institute of Biomedical Science and Technology (AiBST), Wilkins Hospital Block C, Corner J, Tongogara and R. Tangwena road, Harare, Zimbabwe. Electronic address:
Article Synopsis
- The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are particularly dangerous for people with weakened immune systems, leading to high mortality rates from severe bacterial infections.
- This study investigated the antibacterial properties of Azanza garckeana leaf and bark extracts against these pathogens using methods like broth microdilution for testing efficacy and GC-MS for analyzing bioactive compounds.
- Findings revealed that hexane bark extract was highly effective against S. aureus and A. baumannii, while acetone bark extract disrupted bacterial membranes and showed antibiofilm activity against K. pneumonia