Enhanced mercury deposition in Arctic Alaskan lake sediments coincides with early Holocene hydroclimate shift.

Substantial amounts of mercury (Hg) are projected to be released into Arctic watersheds as permafrost thaws amid warmer and wetter conditions. This may have far-reaching consequences because the highly toxic methylated form of Hg biomagnifies rapidly in ecosystems. However, understanding how climate change affects Hg dynamics in permafrost regions is limited due to the lack of long-term Arctic Hg records.

Academic Detailing Interventions and Evidence-Based Prescribing: A Systematic Review.

Importance: Academic detailing (interactive educational outreach) is a widely used strategy to encourage evidence-based prescribing by clinicians.

Objective: To evaluate academic detailing programs targeted at improving prescribing behavior and describe program aspects associated with positive outcomes.

Evidence Review: A systematic search of MEDLINE from April 1, 2007, through December 31, 2022, was performed for randomized trials and nonrandomized studies of academic detailing interventions to improve prescribing.

University students' knowledge, perceptions, and sources of information on routinely recommended vaccines.

To evaluate university students' perceptions of the importance of routine vaccines, knowledge of vaccines, most trusted sources of vaccine information, and interest in learning more about vaccines. 2,223 students attending four universities across Pennsylvania. A 32-question electronic survey was administered to university students between March and May 2023.

Risk Evaluation and Mitigation Strategies for Potential Outbreaks of Nipah Virus Infection: Evidenced by the Recent Incidences in Southeast Asian Countries.

Background: The importance of studying Nipah virus (NiV) stems from its high fatality rates and potential for causing widespread outbreaks. Recent incidences in Southeast Asian countries highlight the urgent need for effective risk evaluation and mitigation strategies.

Justification: Studying NiV in Southeast Asia is crucial due to the geographic and epidemiological significance that makes this region predominantly susceptible to the virus.

Effect of low-frequency blood glucose self-monitoring on glycosylated hemoglobin levels among older adults with type 2 diabetes mellitus.

Background: Reducing the frequency of self-monitoring of blood sugar, due to needle phobia, pain, stress, and costs associated with the procedure, can improve patient compliance and quality of life, provided that adequate blood sugar control is maintained. This study aimed to evaluate the effect of low-frequency blood glucose self-monitoring (LFBGSM) on glycosylated hemoglobin (HbA1) levels among older adults living with type 2 diabetes mellitus (T2DM), treated with or without insulin.

Materials And Methods: This randomized controlled trial with a parallel design was conducted on 121 older adults with T2DM in Sabzevar, Iran, between 2018 and 2020.

The Infection After the COVID-19 Pandemic Seems to be an Urgent Public Health Emergency: A Call to Attention.

Background And Aims: Inconsequential diseases can sometimes become extremely dangerous through mutation. Antifungal resistance has increased by 24%, and resistance only due to () species have increased by 60%. Here, we aimed to assess the knowledge of antifungal treatment and preventative measures to mitigate the consequences of infections caused by .

Macrophage-Expressed Coagulation Factor VII Promotes Adverse Cardiac Remodeling.

Background: Excess fibrotic remodeling causes cardiac dysfunction in ischemic heart disease, driven by MAP (mitogen-activated protein) kinase-dependent TGF-ß1 (transforming growth factor-ß1) activation by coagulation signaling of myeloid cells. How coagulation-inflammatory circuits can be specifically targeted to achieve beneficial macrophage reprogramming after myocardial infarction (MI) is not completely understood.

Methods: Mice with permanent ligation of the left anterior descending artery were used to model nonreperfused MI and analyzed by single-cell RNA sequencing, protein expression changes, confocal microscopy, and longitudinal monitoring of recovery.

Linking Creative Self-Efficacy and Emotional Exhaustion: Mediation Through Cognitive Reappraisal.

Drawing from the motivational emotion regulation perspective and self-verification theory, this study demonstrates the mechanism linking creative self-efficacy and emotional exhaustion in which cognitive reappraisal serves as a mediator. Study 1 ( = 137) conducted in an experimental setting provided evidence for a causal relationship between creative self-efficacy and cognitive reappraisal. Individuals who have higher creative self-efficacy are more likely than those who have lower creative self-efficacy to engage in cognitive reappraisal because they reinterpret potentially emotion-eliciting situations in a way that reduces their emotional impact.

Perceptions of vaccine requirements among students at four Pennsylvania universities.

Background: University students have a unique perspective on vaccination because of their recent or perhaps newly acquired autonomy and ability to make health-related decisions. The development of the COVID-19 vaccine in 2020 and its implementation over the past few years was accompanied by much information and communication about vaccination requirements and safety, which may have affected students' perspectives on vaccination and vaccine requirements more broadly. This analysis describes current vaccine policies at several universities and evaluates student respondents' perceptions of and agreement with university vaccine requirements.

The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice.

Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Developing high-NUE rice cultivars through balancing nitrogen uptake and the formation of productive tillers remains a long-standing challenge, yet how these two processes are coordinated in rice remains elusive. Here we identify the transcription factor OsGATA8 as a key coordinator of nitrogen uptake and tiller formation in rice.

DP-site: A dual deep learning-based method for protein-peptide interaction site prediction.

Background: Protein-peptide interaction prediction is an important topic for several applications including various biological processes, understanding drug discovery, protein function abnormal cellular behaviors, and treating diseases. Over the years, studies have shown that experimental methods have improved the identification of this bio-molecular interaction. However, predicting protein-peptide interactions using these methods is laborious, time-consuming, dependent on third-party tools, and costly.

Enhancing hypertension pharmacotherapeutics education by integrating social determinants of health.

Objective: Social determinants of health (SDOHs) play a significant role in hypertension management. Pharmacy program accreditation standards include that students should understand SDOHs. However, there are limited data regarding approaches to incorporating SDOHs within pharmacotherapeutics courses.

Psychometric evaluation of the United States-adapted perceived perioperative competence scale-revised: A national survey.

Background: Nursing competence is integral to ensuring patient safety, especially in high-risk environments such as the operating room. Instruments which facilitate self-assessment of specialty specific nursing competence allow nurses to gain important insights into their practice to facilitate continuous growth in their professional practice. Currently, there are no psychometrically tested tools to assess perioperative competence applicable to the United States context.

13-Nitro-benzo[][1,4]benzo-thia-zino[3,2-]phenoxazine.

In the title compound, CHNOS, dihedral angle between the phenyl rings on the periphery of the molecule is 8.05 (18)°. In the crystal, aromatic π-π stacking distance and short C-H⋯O contacts are observed.

Liquid-liquid phase separation of TZP promotes PPK-mediated phosphorylation of the phytochrome A photoreceptor.

Phytochrome A (phyA) is the plant far-red (FR) light photoreceptor and plays an essential role in regulating photomorphogenic development in FR-rich conditions, such as canopy shade. It has long been observed that phyA is a phosphoprotein in vivo; however, the protein kinases that could phosphorylate phyA remain largely unknown. Here we show that a small protein kinase family, consisting of four members named PHOTOREGULATORY PROTEIN KINASES (PPKs) (also known as MUT9-LIKE KINASES), directly phosphorylate phyA in vitro and in vivo.

Assessing intradisciplinary pharmacy communication related to transitions of care.

Background: Pharmacists play an important role in transitions of care, where successful communication is vital. The primary objective of this study was to assess the extent of intradisciplinary communication between pharmacists during patient transitions of care. Secondary objectives were to evaluate pharmacist communication practices and to explore the potential barriers and facilitators to effective health communications.

Environmental drivers of increased ecosystem respiration in a warming tundra.

Arctic and alpine tundra ecosystems are large reservoirs of organic carbon. Climate warming may stimulate ecosystem respiration and release carbon into the atmosphere. The magnitude and persistency of this stimulation and the environmental mechanisms that drive its variation remain uncertain.

Perceptions of near-peer teaching in a pharmacy skills-based laboratory.

Objective: To assess the perception of students, faculty, and previous lab coaches on a near-peer teaching model integrated into a skills-based laboratory.

Methods: As part of a longitudinal near-peer teaching experience, third professional year students are utilized as lab coaches in a skills-based laboratory course. Lab coaches deliver lectures, provide feedback, facilitate activities, and assist with class preparation spanning 2 semesters for first and second professional year students.

Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes.

Background: Providing analgesia and sedation is an essential component of caring for many mechanically ventilated patients. The selection of analgesic and sedative medications during the COVID-19 pandemic, and the impact of these sedation practices on patient outcomes, remain incompletely characterized.

Research Question: What were the hospital patterns of analgesic and sedative use for patients with COVID-19 who received mechanical ventilation (MV), and what differences in clinical patient outcomes were observed across prevailing sedation practices?

Study Design And Methods: We conducted an observational cohort study of hospitalized adults who received MV for COVID-19 from February 2020 through April 2021 within the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) COVID-19 Registry.

Masting promotes transformation from predation to mutualism in an oak-weevil-rodent system.

The significance of ecological non-monotonicity (a function whose first derivative changes signs) in shaping the structure and functions of the ecosystem has recently been recognized, but such studies involving high-order interactions are rare. Here, we have proposed a three-trophic conceptual diagram on interactions among trees, rodents, and insects in mast and non-mast years and tested the hypothesis that oak (Quercus wutaishanica) masting could result in increased mutualism and less predation in an oak-weevil-rodent system in a warm temperate forest of China. Our 14-year dataset revealed that mast years coincided with a relatively low rodent abundance but a high weevil abundance.