Evidence for H-bonding interactions to the μ-η:η-peroxide of oxy-tyrosinase that activate its coupled binuclear copper site.

The factors that control the diverse reactivity of the μ-η:η-peroxo dicopper(II) oxy-intermediates in the coupled binuclear copper proteins remain elusive. Here, spectroscopic and computational methods reveal H-bonding interactions between active-site waters and the μ-η:η-peroxide of oxy-tyrosinase, and define their effects on the Cu(II)O electronic structure and O activation.

Recent Advances in Understanding the Structure and Function of the Human Microbiome.

Trillions of microbes live within our bodies in a deep symbiotic relationship. Microbial populations vary across body sites, driven by differences in the environment, immunological factors, and interactions between microbial species. Major advances in genome sequencing enable a better understanding of microbiome composition.

Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline.

Histones and their posttranslational modifications facilitate diverse chromatin functions in eukaryotes. Core histones (H2A, H2B, H3, and H4) package genomes after DNA replication. In contrast, variant histones promote specialized chromatin functions, including DNA repair, genome stability, and epigenetic inheritance.

White Parents' Socialization of Racial Attitudes: A Commentary on Scott et al. (2020).

In the September 2020 issue of , Scott et al. argued that there is insufficient empirical work on White parents' racial-socialization strategies to support generalizations about the topic and, therefore, that journalists' recommendation that White parents discuss race and racism with their children represents a case of speculation without evidence. Although we strongly support Scott et al.

Don't let the pigeon chair the search committee: Pigeons (Columba livia) match humans' (Homo sapiens) suboptimal approach to the secretary problem.

The secretary problem is a notorious mathematical puzzle in which one attempts to hire the best available candidate from a pool of known size. Under specific constraints, the problem has an ideal solution, but it is difficult for humans to solve. In particular, humans generally consider too few options from the available pool and in doing so make inferior hires.

The Primarily Undergraduate Nanomaterials Cooperative: A New Model for Supporting Collaborative Research at Small Institutions on a National Scale.

The Primarily Undergraduate Nanomaterials Cooperative (PUNC) is an organization for research-active faculty studying nanomaterials at Primarily Undergraduate Institutions (PUIs), where undergraduate teaching and research go hand-in-hand. In this perspective, we outline the differences in maintaining an active research group at a PUI compared to an R1 institution. We also discuss the work of PUNC, which focuses on community building, instrument sharing, and facilitating new collaborations.

Self-defining memories-Narrative features in relation to adaptive and maladaptive personality traits (replication and extension of Blagov & Singer, 2004).

Objective: Self-defining memories (SDMs) are units of life-story analysis, whose features resemble elements from narrative identity's factorial structure. To bridge narrative-identity and personality-trait domains, we conducted a replication and extension of prior research.

Method: We linked four SDM features - affect, specificity, meaning making, and content - to the Big Three trait domains of personality and psychopathology in a small sample that was well-powered for multilevel modeling (133 participants, 1330 SDMs).

Melanic pigmentation and light preference within and between two species.

Environmental adaptation and species divergence often involve suites of co-evolving traits. Pigmentation in insects presents a variable, adaptive, and well-characterized class of phenotypes for which correlations with multiple other traits have been demonstrated. In , the pigmentation genes and have pleiotropic effects on flies' response to light, creating the potential for correlated evolution of pigmentation and vision.

MouseView.js: Reliable and valid attention tracking in web-based experiments using a cursor-directed aperture.

Psychological research is increasingly moving online, where web-based studies allow for data collection at scale. Behavioural researchers are well supported by existing tools for participant recruitment, and for building and running experiments with decent timing. However, not all techniques are portable to the Internet: While eye tracking works in tightly controlled lab conditions, webcam-based eye tracking suffers from high attrition and poorer quality due to basic limitations like webcam availability, poor image quality, and reflections on glasses and the cornea.

Gangbangin on the [Face]Book: Understanding Online Interactions of Chicago Latina/o Gangs.

Objectives: This study examines gang group processes on the digital street to understand if gang processes in the online environment mimic those on geographic street corners. Specifically, this paper examines what conditions influence whether gangs interact negatively or positively in online spaces and how online interactions relate to geographic proximity of gangs.

Methods: This study uses digital trace data web scraped from a public Facebook about Chicago Latina/o gangs combined with geographic locations of gang territories.

Adaptive and Dark Personality in the COVID-19 Pandemic: Predicting Health-Behavior Endorsement and the Appeal of Public-Health Messages.

Who embraces directions to socially distance, boost hygiene, and protect others during a pandemic of contagious respiratory disease? Do differently phrased public-health messages appeal to different people? I based predictions on the five-factor, triarchic psychopathy, and Dark Triad models of normal-range and dark traits; the extended parallel process model (EPPM); and schema-congruence theory. In a survey of 502 online participants, normal-range traits (esp agreeableness and conscientiousness) predicted endorsement of social distancing and hygiene, as well as the appeal of health messages in general. Consistent with the EPPM, conscientiousness and neuroticism had an interaction.

The Systems and Synthetic Biology of Auxin.

Auxin biology as a field has been at the forefront of advances in delineating the structures, dynamics, and control of plant growth networks. Advances have been enabled by combining the complementary fields of top-down, holistic systems biology and bottom-up, build-to-understand synthetic biology. Continued collaboration between these approaches will facilitate our understanding of and ability to engineer auxin's control of plant growth, development, and physiology.

Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.

The etiology of necrotizing enterocolitis (NEC) is not known. Alterations in gut microbiome, mucosal barrier function, immune cell activation, and blood flow are characterized events in its development, with stress as a contributing factor. The hormone corticotropin-releasing factor (CRF) is a key mediator of stress responses and influences these aforementioned processes.

Neurophysiological coordination of duet singing.

Coordination of behavior for cooperative performances often relies on linkages mediated by sensory cues exchanged between participants. How neurophysiological responses to sensory information affect motor programs to coordinate behavior between individuals is not known. We investigated how plain-tailed wrens () use acoustic feedback to coordinate extraordinary duet performances in which females and males rapidly take turns singing.

Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease.

The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone.

Beyond vernacular: Measurement solutions to the lexical fallacy in disgust research.

Disgust may play an important role in several mental disorders, in part because disgust seems impervious to corrective information, a feature noted long before it was studied by clinical psychologists. A deeper understanding of disgust could improve not only the treatment of mental disorders, but also other societal problems involving this peculiar emotion. In this paper, we review the measurement of disgust and identify issues that hold back progress in understanding how to treat this emotion.

Aseptic Viral Meningitis Secondary to Herpes Simplex Virus 2 Genital Infection.

Aseptic viral meningitis is the most common cause of meningitis in the United States. Most cases of herpes simplex virus meningitis are caused by herpes simplex virus type 2 (HSV-2), with HSV-1 primarily causing viral encephalitis. In this report, we present a case of aseptic meningitis generated by the HSV-2 in an immunosuppressed 35-year-old female with a recent diagnosis of genital herpes that was left untreated due to reported side effects of medication.

Preferred reporting items for systematic reviews and meta-analyses in ecology and evolutionary biology: a PRISMA extension.

Since the early 1990s, ecologists and evolutionary biologists have aggregated primary research using meta-analytic methods to understand ecological and evolutionary phenomena. Meta-analyses can resolve long-standing disputes, dispel spurious claims, and generate new research questions. At their worst, however, meta-analysis publications are wolves in sheep's clothing: subjective with biased conclusions, hidden under coats of objective authority.

is associated with roots of the perennial grass in Pacific Northwest prairies.

Prairies in the Pacific Northwest are dominated by perennial bunchgrasses. A in the complex was observed to tightly co-occur with bunchgrasses at several prairie study sites. Mapping and spatial statistics showed that it was strongly and significantly associated with tussocks.

Endosperm-based incompatibilities in hybrid monkeyflowers.

Endosperm is an angiosperm innovation central to their reproduction whose development, and thus seed viability, is controlled by genomic imprinting, where expression from certain genes is parent-specific. Unsuccessful imprinting has been linked to failed inter-specific and inter-ploidy hybridization. Despite their importance in plant speciation, the underlying mechanisms behind these endosperm-based barriers remain poorly understood.

Habitat influences skeletal morphology and density in the snailfishes (family Liparidae).

We tested the hypothesis that deep-sea fishes have poorly mineralized bone relative to shallower-dwelling species using data from a single family that spans a large depth range. The family Liparidae (snailfishes, Cottiformes) has representatives across the entire habitable depth range for bony fishes (0 m-> 8000 m), making them an ideal model for studying depth-related trends in a confined phylogeny. We used micro-computed tomography (micro-CT) scanning to test three aspects of skeletal reduction in snailfishes (50 species) across a full range of habitat depths: 1) reduction of structural dimensions, 2) loss of skeletal elements, and 3) reduction in bone density.