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[D-Ala, D-Leu] Enkephalin Improves Liver Preservation During Normothermic Ex Vivo Perfusion.
J Surg Res
September 2019
The COPPER Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio; The Ohio State University, Wexner Medical Center Comprehensive Transplant Center, Columbus, Ohio. Electronic address:
Background: Meeting the metabolic demands of donor livers using normothermic ex vivo liver perfusion (NEVLP) preservation technology is challenging. The delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) has been reported to decrease the metabolic demand in models of ischemia and cold preservation. We evaluated the therapeutic potential of DADLE by investigating its ability to protect against oxidative stress and hepatic injury during normothermic perfusion.
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