571 results match your criteria: "Westmead Millennium Institute for Medical Research and University of Sydney; linda.bendall@sydney.edu.au.[Affiliation]"
Lancet Gastroenterol Hepatol
November 2024
Division of Gastroenterology, Hepatology, and Nutrition and Richmond VA Medical Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:
Background: Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.
Methods: In this prospective cohort study initiated by the CLEARED Consortium, we enrolled adults (aged >18 years) with cirrhosis who were non-electively admitted to 98 hospitals from 26 countries or regions across six continents between Nov 5, 2021, and Dec 10, 2022.
J Cyst Fibros
September 2024
Department of Respirology, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021.
Objective: To determine the psychometric properties of an Aboriginal and Torres Strait Islander-developed depressive symptom screening scale.
Design: Prospective diagnostic accuracy study.
Setting: Ten primary health care services or residential alcohol and other drug rehabilitation services in Australia that predominantly serve Aboriginal and Torres Strait Islander peoples.
Front Endocrinol (Lausanne)
July 2024
Department of Vascular Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Background: Bile acids (BAs), products of gut microbiota metabolism, have long been implicated in atherosclerotic disease pathogenesis. Characterizing the serum bile acid profile and exploring its potential role in carotid atherosclerosis (CAS) development are crucial tasks.
Methods: In this study, we recruited 73 patients with CAS as the disease group and 77 healthy individuals as the control group.
Oncol Lett
September 2024
Institute of Cancer Biology, Basic Medical Sciences Center, School of Basic Medicine, Shanxi Medical University, Jinzhong, Shanxi 030600, P.R. China.
T cells play an important role in adaptive immunity. Mature T cells specifically recognize antigens on major histocompatibility complex molecules through T-cell receptors (TCRs). As the TCR repertoire is highly diverse, its analysis is vital in the assessment of T cells.
View Article and Find Full Text PDFEur J Cancer
July 2024
Melanoma Institute Australia, University of Sydney, Sydney, NSW, Australia; Faculty of Medicine & Health, The University of Sydney, NSW, Australia; Charles Perkins Centre, The University of Sydney, NSW, Australia; Royal North Shore and Mater Hospitals, Sydney, Australia. Electronic address:
Cochrane Database Syst Rev
May 2024
Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Cancer Immunol Immunother
December 2023
Hematology Department, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui Province, People's Republic of China.
Increasing evidence suggests that mucosal-associated invariant T cells (MAITs) play a crucial role in anti-tumor responses against various cancers. In this study, we investigated the immune characteristics of MAIT cells in patients with acute myeloid leukemia (AML). Using multi-parameter flow cytometry, we performed phenotypic and functional analysis of MAITs in peripheral blood or bone marrow samples collected from 131 patients with AML including 99 newly diagnosed, 18 remission, and 14 relapsed cases, as well as 69 healthy controls.
View Article and Find Full Text PDFHepatol Res
December 2023
Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Laboratory for Clinical and Experimental Hepatology, Leipzig, Germany.
Aim: Interleukin (IL)-10 and IL-12 contribute to immune responses against hepatitis B virus (HBV) infection. Polymorphisms in the IL-10 and IL-12A genes might affect the clinical outcome of HBV infection. We evaluated the association of IL-10 rs1800896 and rs3024490, and IL-12A rs568408 and rs2243115 with the progression of HBV infection and development of severe liver disease stages in a white European population.
View Article and Find Full Text PDFDig Liver Dis
February 2024
Department of Gastroenterology, Portsmouth Hospitals University NHS Trust, Portsmouth, UK; School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Background/objective: Increasing infectious rate estimates and low microbiological surveillance affect safety of gastrointestinal endoscopy globally. Single use endoscopes and accessories have been claimed to improve safety, but there is lack of data on their indication and sustainability. We aimed to identify a series of best practice recommendations for the use of single use endoscopes and accessories using a modified Delphi.
View Article and Find Full Text PDFLancet Gastroenterol Hepatol
July 2023
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Int J Womens Health
April 2023
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, Australia.
Pathogens
December 2022
Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, 04103 Leipzig, Germany.
Interleukin-1 beta (IL-1β) promotes liver disease progression and hepatocarcinogenesis in chronic hepatitis B (CHB). Single nucleotide polymorphisms (SNPs) within the promotor region of the gene can affect the progression towards liver cirrhosis and hepatocellular carcinoma (HCC). We aimed to investigate the association of three common SNPs with hepatitis B virus (HBV)-related HCC in Caucasian patients.
View Article and Find Full Text PDFBr J Cancer
April 2023
Leiden University Medical Center, Leiden, The Netherlands.
Background: Up to 50% of patients with uveal melanoma develop metastases (MUM) with a poor prognosis and median overall survival of approximately 1 year.
Methods: This phase I study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the oral protein kinase C inhibitor LXS196 in 68 patients with MUM (NCT02601378). Patients received LXS196 doses ranging from 100-1000 mg once daily (QD; n = 38) and 200-400 mg twice daily (BID; n = 30).
Nature
October 2022
Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Eur J Cancer
November 2022
UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) versus placebo in resected stage IIB and IIC melanoma in the phase 3 KEYNOTE-716 study. Health-related quality of life (HRQoL) results are reported.
Methods: Patients were randomly assigned 1:1 to pembrolizumab 200 mg (2 mg/kg, patients ≥12 to <18 years) Q3W or placebo for ≤17 cycles or until disease recurrence, unacceptable toxicity, or withdrawal.
Diabetes Res Clin Pract
September 2022
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Reproduction and Perinatal Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address:
Aims: To determine the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its association on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM).
Methods: 380 women with GDM had a FibroScan® performed between 24 and 32 weeks. A Controlled Attenuation Parameter (CAP) ≥ 233.
Front Nutr
March 2022
Storr Liver Centre, Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia.
Immune checkpoint inhibitors (ICIs) have shown durable remissions and improved long-term survival across a variety of cancer types. However, there is growing evidence that a significant subset of nonresponsive patients may exhibit hyperprogressive disease (HPD) during the initiation of immune checkpoint inhibitors (ICIs). Moreover, patients with HPD triggered by ICIs are always correlated with a deteriorating quality of life and poor prognosis.
View Article and Find Full Text PDFPort J Public Health
April 2022
Department of Psychology and Education, Universidade da Beira Interior, Covilhã, Portugal.
Introduction: Since exposure to potentially traumatic events during childhood and adolescence has been shown to be very common, its screening is very important. Our aim was to develop a self-assessment checklist to perform screening of potentially traumatic events in childhood and adolescence.
Methods: The development of the Checklist of Potentially Traumatic Events in Children and Adolescents (CEPT-CA) was based on: (a) the structure of Life Events Checklist that has been translated, back-translated, and adapted; (b) recommendations of renowned entities about trauma in childhood; (c) particularities of potentially traumatic events in childhood; (d) adapting the language to the target population's age group; (e) Portugal's sociocultural context.
J Am Soc Nephrol
May 2022
Centre for Kidney Research, The Children's Hospital at Westmead, The University of Sydney, Westmead, New South Wales, Australia.
Background: The cytokine IL-33 is an activator of innate lymphoid cells 2 (ILC2s) in innate immunity and allergic inflammation. B cell activating factor (BAFF) plays a central role in B cell proliferation and differentiation, and high levels of this protein cause excess antibody production, including IgA. BAFF-transgenic mice overexpress BAFF and spontaneously develop glomerulonephritis that resembles human IgA nephropathy.
View Article and Find Full Text PDFCancer
June 2022
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Background: Conditional survival estimates provide critical prognostic information for patients with advanced renal cell carcinoma (aRCC). Efficacy, safety, and conditional survival outcomes were assessed in CheckMate 214 (ClinicalTrials.gov identifier NCT02231749) with a minimum follow-up of 5 years.
View Article and Find Full Text PDFGut
December 2022
Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, New South Wales, Australia.
Objective: Management of covert submucosal invasive cancer (SMIC) discovered after piecemeal endoscopic mucosal resection (pEMR) of large (>20 mm) non-pedunculated colorectal polyps is challenging. The residual cancer risk is largely unknown. We sought to evaluate this in a large tertiary referral cohort.
View Article and Find Full Text PDFCochrane Database Syst Rev
February 2022
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Background: Antiplatelet agents are widely used to prevent cardiovascular events. The risks and benefits of antiplatelet agents may be different in people with chronic kidney disease (CKD) for whom occlusive atherosclerotic events are less prevalent, and bleeding hazards might be increased. This is an update of a review first published in 2013.
View Article and Find Full Text PDFJ Clin Oncol
April 2022
Melanoma Institute Australia, The University of Sydney, Sydney, Australia.
Purpose: Currently, there are no robust biomarkers that predict immunotherapy outcomes in metastatic melanoma. We sought to build multivariable predictive models for response and survival to anti-programmed cell death protein 1 (anti-PD-1) monotherapy or in combination with anticytotoxic T-cell lymphocyte-4 (ipilimumab [IPI]; anti-PD-1 ± IPI) by including routine clinical data available at the point of treatment initiation.
Methods: One thousand six hundred forty-four patients with metastatic melanoma treated with anti-PD-1 ± IPI at 16 centers from Australia, the United States, and Europe were included.