5 results match your criteria: "Westlake University and Westlake Institute for Advanced Study[Affiliation]"
Relationship between alcohol use, blood pressure and hypertension: an association study and a Mendelian randomisation study.
J Epidemiol Community Health
September 2019
Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China
Background: Past studies have found a strong relationship between alcohol drinking and human health.
Methods: In this study, we first tested the association of rs671 with alcohol use in 2349 participants in southeast China. We then evaluated the causal impact between alcohol use and cardiovascular traits through a Mendelian randomisation (MR) analysis.
Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.
Lipids Health Dis
March 2019
Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Background: CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.
Materials And Methods: Twenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis.
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
Nat Commun
October 2018
Erasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.
Article Synopsis
- Thyroid dysfunction affects about 10% of the population and is linked to higher risks of heart problems and death.
- A large analysis of genetic studies involving 72,167 individuals identified 109 genetic variants related to thyroid function and disease.
- Researchers found a new thyroid hormone transporter and metabolizing enzyme, which could lead to new treatment options for thyroid-related issues.
Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis.
Arch Dermatol Res
November 2018
Diseases & Population (DaP) Geninfo Lab, School of Life Sciences, Westlake University and Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2.
View Article and Find Full Text PDFAssessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.
BMJ
August 2018
Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Objectives: To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk.
Design: Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach.
Setting: 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data.