1 results match your criteria: "Western University Schulich School of Medicine and Dentistry and Children's Health Research Institute[Affiliation]"
Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
Arthritis Rheumatol
October 2015
Western University Schulich School of Medicine and Dentistry and Children's Health Research Institute, London, Ontario, Canada.
Objective: Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is increased in OA cartilage and stimulates proteoglycan loss. This study was undertaken to test whether TGFα and CCL2 cooperate to promote cartilage degradation and whether inhibiting either reduces disease progression in a rat model of posttraumatic OA.
View Article and Find Full Text PDF