Finalizing the Work Related to the Curriculum Outcomes and Example Objectives and Entrustable Professional Activities (COEPA) Document: The Report of the 2022-2023 Academic Affairs Standing Committee.

The 2022-2023 Academic Affairs Committee (AAC) was charged to (1) complete the Center for the Advancement of Pharmacy Education Outcomes and Entrustable Professional Activities (EPAs) revisions (now renamed as COEPA - Curriculum Outcomes and Entrustable Professional Activities) after receiving feedback at the 2022 American Association of Colleges of Pharmacy (AACP) Annual Meeting; (2) offer guidance on how the revised COEPA education outcomes and EPA statements should be used by member institutions, faculty, preceptor, and students; (3) guide input into the ongoing revision of the Accreditation Council for Pharmacy Education (ACPE) standards for the Doctor of Pharmacy program. The published report of the 2021-2022 AAC outlines the work of the Committee through the spring of 2022. This 2022-2023 AAC report focuses on the work related to finalizing the COEPA educational outcomes, EPAs, preamble, and glossary and formally receiving approval from the AACP Board of Directors.

The AACP Academic Affairs Committee's Final 2022 Curricular Outcomes and Entrustable Professional Activities (COEPA) for Pharmacy Graduates to Replace 2013 CAPE and 2016 EPAs.

The American Association of Colleges of Pharmacy (AACP) Academic Affairs Committee was charged with revising both the 2013 Center for the Advancement of Pharmacy Education (CAPE) Educational Outcomes (EOs) and the 2016 Entrustable Professional Activities (EPAs). The Committee changed the document name from the CAPE outcomes to COEPA, (Curricular Outcomes and Entrustable Professional Activities) since the EOs and EPAs would now be housed together. A draft of the COEPA EOs and EPAs was released at the AACP July 2022 Annual meeting.

Revising the Center for the Advancement of Pharmacy Education (CAPE) Educational Outcomes and Entrustable Professional Activities (EPAs): The Report of the 2021-2022 Academic Affairs Standing Committee.

The 2021-22 Academic Affairs Committee was charged to 1) Update the Center for the Advancement of Pharmacy Education (CAPE) Outcomes and Entrustable Professional Activity (EPA) statements for new pharmacy graduates; 2) Nominate at least one person for an elected AACP or Council Office; and 3) Consider ways that AACP can improve its financial health. This report primarily focuses on the process undertaken by the committee to revise the CAPE Educational Outcomes and EPAs. Proposed changes to the current outcomes are discussed and the reasoning behind these revisions are described.

Identifying areas of improvement for cultural competence in pharmacy curricula: A multi-school study using the self-assessment of perceived level of cultural competence (SAPLCC) questionnaire.

Introduction: The implementation of culturally competent healthcare services has been considered a key strategy for the provision of patient-centered care; however, a need remains to address the requirements of teaching cultural competence, including identifying gaps, designing and evaluating curricula, and assessing students' progress toward program objectives. The objective of this study was to explore the applicability of the Self-Assessment of Perceived Level of Cultural Competence (SAPLCC) questionnaire in the identification of improvement areas in cultural competence content in pharmacy curricula.

Methods: This study used previously-collected SAPLCC data from student pharmacists at eight United States pharmacy schools.

History of Respiratory Stimulants.

The interest in substances that stimulate respiration has waxed and waned throughout the years, intensifying following the introduction of a new class of drugs that causes respiratory depression, and diminishing when antidotes or better drug alternatives are found. Examples include the opioids--deaths increasing during overprescribing, diminishing with wider availability of the opioid receptor antagonist naloxone, increasing again during COVID-19; the barbiturates--until largely supplanted by the benzodiazepines; propofol; and other central nervous system depressants. Unfortunately, two new troubling phenomena force a reconsideration of the status-quo: (1) overdoses due to highly potent opioids such as fentanyl, and even more-potent licit and illicit fentanyl analogs, and (2) overdose due to polysubstance use (the combination of an opioid plus one or more non-opioid drug, such as a benzodiazepine, sedating antidepressant, skeletal muscle relaxant, or various other agents).

Revisiting Faculty Citizenship.

This commentary describes the significance of faculty citizenship in the broader context of institutional culture and defines faculty citizenship for use across all aspects of faculty roles in the Academy. The definition includes two key components (engagement and collegiality) that can be used to measure citizenship behaviors. Continued discussion and study of faculty citizenship will further the Academy's understanding and use of the concept.

In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis.

Background: There is a need to have a model to study methadone's losses during hemodialysis to provide informed methadone dose recommendations for the practitioner.

Aim: To build a one-dimensional (1-D), hollow-fiber geometry, ordinary differential equation (ODE) and partial differential equation (PDE) countercurrent hemodialyzer model (ODE/PDE model).

Methodology: We conducted a cross-sectional study in silico that evaluated eleven hemodialysis patients.

The Effects of Multiple Exemplar Instruction on the Relation Between Listener and Intraverbal Categorization Repertoires.

We evaluated the effects of multiple exemplar instruction (MEI) on the relation between listener and intraverbal categorization repertoires of six typically developing preschool-age children using a nonconcurrent multiple-probe design across participants. After failing to emit intraverbal categorization responses following listener categorization training, participants were exposed to MEI in the form of alternating response forms (listener and intraverbal) during categorization training with novel stimulus sets. For two participants for whom there was some evidence of emergent intraverbal responding, responding was variable.

Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing.

Objectives: (1) To quantify hydrocodone (HC) and hydromorphone (HM) metabolite pharmacokinetics with pharmacogenetics in CYP2D6 ultra-rapid metabolizer (UM), extensive metabolizer (EM), and poor metabolizer (PM) metabolizer phenotypes. (2) To develop an HC phenotype-specific dosing strategy for HC that accounts for HM production using clinical pharmacokinetics integrated with pharmacogenetics for patient safety.

Setting: In silico clinical trial simulation.

Functional analysis and treatment of arranging and ordering by individuals with an autism spectrum disorder.

Of the diagnostic features of autism, relatively little research has been devoted to restricted and repetitive behavior, particularly topographically complex forms of restricted and repetitive behavior such as rigidity in routines or compulsive-like behavior (e.g., arranging objects in patterns or rows).

Iterative Development of an Application to Support Nuclear Magnetic Resonance Data Analysis of Proteins.

The CONNecticut Joint University Research (CONNJUR) team is a group of biochemical and software engineering researchers at multiple institutions. The vision of the team is to develop a comprehensive application that integrates a variety of existing analysis tools with workflow and data management to support the process of protein structure determination using Nuclear Magnetic Resonance (NMR). The use of multiple disparate tools and lack of data management, currently the norm in NMR data processing, provides strong motivation for such an integrated environment.

Description of a practitioner model for identifying preferred stimuli with individuals with autism spectrum disorders.

The rich technology of stimulus preference assessment (SPA) is a product of 40 years of experimental research. Basic principles of reinforcement and a modest empirical literature suggest that high-preference stimuli identified via SPA may enhance treatment efficacy and decrease problem behavior more effectively than less-preferred stimuli. SPAs can be conducted using one of several methods associated with different time requirements and outcomes.

Effects of a history of differential reinforcement on preference for choice.

The effects of a history of differential reinforcement for selecting a free-choice versus a restricted-choice stimulus arrangement on the subsequent responding of 7 undergraduates in a computer-based game of chance were examined using a concurrent-chains arrangement and a multiple-baseline-across-participants design. In the free-choice arrangement, participants selected three numbers, in any order, from an array of eight numbers presented on the computer screen. In the restricted-choice arrangement, participants selected the order of three numbers preselected from the array of eight by a computer program.

Examining the generality of children's preference for contingent reinforcement via extension to different responses, reinforcers, and schedules.

Studies that have assessed whether children prefer contingent reinforcement (CR) or noncontingent reinforcement (NCR) have shown that they prefer CR. Preference for CR has, however, been evaluated only under continuous reinforcement (CRF) schedules. The prevalence of intermittent reinforcement (INT) warrants an evaluation of whether preference for CR persists as the schedule of reinforcement is thinned.

What Every Behavior Analyst Should Know About the "MMR Causes Autism" Hypothesis.

In 1998, the English physician Andrew Wakefield suggested that the MMR vaccine insults the guts of children who then regress developmentally and become autistic. Although his research did not provide firm evidence for this hypothesis, many believe that (a) the MMR vaccine can cause autism; (b) children with autism typically have gastrointestinal problems; and, (c) a necessary component of treating autism is "treating the gut" through dietary restrictions. Research has subsequently shown that Wakefield's hypothesis is unquestionably false, children with autism are not more likely to have gastrointestinal problems, and there is no sound evidence that diets are a valid treatment for autism.

Toward effective and preferred programming: a case for the objective measurement of social validity with recipients of behavior-change programs.

The adoption of effective behavioral interventions and teaching strategies for young children is largely influenced by the extent to which stakeholders find the procedures appropriate and the effects important. Stakeholder values have been described by measures of social validity in applied behavior analysis, and these measures have been a part of behavior-analytic research and practice since their important characteristics were described in the late 1970s. The typically subjective nature of the social validation process appears, however, to have marginalized children and other usual recipients of behavior-change procedures (i.

Just a spoonful of sugar: drug safety for pediatric populations.

Children deserve optimal medical care. Although prescription drugs play a prominent and essential role in pediatric health care delivery, health care providers often must make prescribing decisions for their young patients based on imperfect or absent safety and efficacy data for pediatric populations. The safe and effective use of prescription drugs in children depends on a thorough understanding of the physiologic differences between children and adults.

Stereotype threat and the exercise/dietary health intentions of overweight women.

Overweight individuals face significant prejudice and discrimination in daily life yet it is not well understood how factors associated with prejudice and discrimination (i.e. negative social stereotypes) impact overweight individuals' exercise/dietary health intentions.

Dental students treating patients living with HIV/AIDS: the influence of attitudes and HIV knowledge.

As life expectancy for people living with HIV/AIDS (PLWHA) increases, these individuals will have greater need for competent and compassionate oral health care. Unfortunately, PLWHA face many significant barriers to receiving adequate oral health care, due in part to the fear of being stigmatized or discriminated against by dental care providers (DCPs). Although many studies have documented accounts of prejudice and discrimination toward PLWHA in the dental health care setting, few have developed theoretical explanations as to why these attitudes and behaviors persist or how they can be effectively ameliorated.

Surface solitons in three dimensions.

We study localized modes on the surface of a three-dimensional dynamical lattice. The stability of these structures on the surface is investigated and compared to that in the bulk of the lattice. Typically, the surface makes the stability region larger, an extreme example of that being the three-site "horseshoe"-shaped structure, which is always unstable in the bulk, while at the surface it is stable near the anticontinuum limit.

The electrochemical impedance of polarized 316L stainless steel: structure-property-adsorption correlation.

Electrochemical (EC) impedance and polarization data were synergistically coupled with AFM micrographs providing insight on the polarized alloy-electrolyte interface. Several regions of oxide topography/ impedance characteristic were apparent on a 316L SS surface. A relatively rough surface with apparent EC reaction products was observed below -500 mV.

A method for describing preschoolers' activity preferences.

We designed a series of analyses to develop a measurement system capable of simultaneously recording the free-play patterns of 20 children in a preschool classroom. Study 1 determined the intermittency with which the location and engagement of each child could be momentarily observed before the accuracy of the measurement was compromised. Results showed that intervals up to 120 s introduced less than 10% measurement error.