Characteristics of mandates for evidence-based behavioral health interventions in 8 selected US states.

Purpose: Demand for the use of evidence-based interventions (EBI) to address behavioral health issues remains high in the United States. States are primarily tasked with determining what constitutes EBIs on a state-by-state basis. This results in variations in what constitutes an EBI across states.

Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS.

The subject of substance use disorders in the pediatric population remains a disturbing conundrum for clinicians, researchers and society in general. Many of our youth are at risk of being damaged and even killed by drug addictions that result from the collision of rapidly developing as well as vulnerable central nervous systems encountering the current global drug addiction crisis. A major motif of this chemical calamity is opioid use disorder in adolescents and young adults that was stimulated by the 19th century identification of such highly addictive drugs as morphine, heroin and a non-opiate, cocaine.

Effects of Movement Sonification Auditory Feedback on Repetitions and Brain Activity During the Bench Press.

Garner, C, Nachtegall, A, Roth, E, Sterenberg, A, Kim, D, Michael, T, and Lee, S. Effects of movement sonification auditory feedback on repetitions and brain activity during the bench press. J Strength Cond Res 38(12): 2022-2028, 2024-Auditory stimulation and feedback have been found to enhance aspects of motor performance such as motor learning, sense of agency, and movement execution.

Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis.

Background: Patients on long-term dialysis for end-stage kidney disease have a high mortality rate, predominantly due to sudden cardiac death (SCD), which is associated with an increased risk of arrhythmias compared to the general population. Thus, the current systematic review and meta-analysis aimed to investigate the incidence of SCD among dialysis patients at risk of arrhythmia.

Methods: This systematic review and meta-analysis followed the PRISMA guidelines.

Developing a patient toolkit for opioid use and management through co-creation.

Canada has been experiencing an opioid use crisis, and urgent efforts are being made to stem the tide. With funding support from Health Canada, the Association of Faculties of Medicine of Canada (AFMC) recently developed a series of asynchronous online bilingual modules to educate key players across the medical education spectrum on chronic pain and opioid use. The curriculum for the modules which informed the development of the Patient-Physician Partnership Toolkit was co-created through an authentic collaboration between healthcare professionals (HCPs), and patient subject matter experts who were patients with lived experience.

Vocational Skill Fluency Through Frequency Building.

Employment offers many important benefits yet the majority of adults with disabilities are not represented in the workforce suggesting more research is needed on evidence-based vocational training for adults with disabilities (U.S. Bureau of Labor Statistics, 2024).

Perceptions of Machine Learning among Therapists Practicing Applied Behavior Analysis: A National Survey.

Unlabelled: Collecting data and logging behaviors of clients who have autism spectrum disorder (ASD) during applied behavior analysis (ABA) therapy sessions can be challenging in real time, especially when the behaviors require a rapid response, like self-injury or aggression. Little information is available about the automation of data collection in ABA therapy, such as through machine learning (ML). Our survey of ABA therapists nationally revealed mixed levels of familiarity with ML and generally neutral responses to statements endorsing the benefits of ML.

Tracing fineware production in the Neo-Assyrian empire: Neutron activation analysis of common and Palace Ware in the upper Tigris River Valley, Turkey.

In the Iron Age, the Neo-Assyrian empire (c. 900-600 BC) conquered territory across southwest Asia and established regional capitals along its borders to secure its gains. Governors at these centers oversaw resource extraction and craft production for shipment to the imperial heartland in modern-day northern Iraq.

Yerba mate () genome provides new insights into convergent evolution of caffeine biosynthesis.

Yerba mate (YM, ) is an economically important crop marketed for the elaboration of mate, the third-most widely consumed caffeine-containing infusion worldwide. Here, we report the first genome assembly of this species, which has a total length of 1.06 Gb and contains 53,390 protein-coding genes.

The impact of osteopathic recognition on multiple medical specialty residencies in a university-based setting.

Context: In 2020, the allopathic and osteopathic residency programs were merged into a single residency system, with the Accreditation Council for Graduate Medical Education (ACGME) as the sole accreditor for residencies and fellowships in the United States. As a result of this merger, osteopathic recognition (OR) emerged as a unique approach to promoting osteopathic training and practice. However, there is a lack of data on the effects of OR in residency, specifically university-based residency programs.

Phylogenomic resolution of lampreys reveals the recent evolution of an ancient vertebrate lineage.

Jawless vertebrates once dominated Palaeozoic waters, but just two lineages have persisted to the present day: lampreys and hagfishes. Living lampreys are a relatively small clade, with just over 50 species described, but knowledge of their evolutionary relationships has always been based on either a few mitochondrial genes or a small number of taxa. Biogeographers have noted the disjunct antitropical distribution of living lamprey families.

A Brief Online Intervention to Increase Use of Nonphysical Discipline Approaches: A Randomized Controlled Trial.

Moderate levels of child disruptive behavior are common and developmentally appropriate during toddlerhood. Caregiver discipline methods influence the development of regulatory strategies in children and the trajectory of behavior problems as children develop. Spanking is a commonly used discipline method in the United States that has been found to result in negative outcomes in childhood and adulthood.

Anomalies in Long-Crack Propagation at Low ΔK in Some Engineering Alloys.

In this article, we discuss an unusual pattern in long-crack behavior at low stress intensity factor ranges ΔK (below ΔK), characterized by an initial dip, followed by a plateau, and then an acceleration in fatigue crack growth (FCG) rate. This unanticipated FCG behavior was first observed experimentally in the IMI 834 alloy and reported by Marci in 1996. Such an anomaly is only reported from experimental observation but cannot be understood or explained using the plasticity, roughness, or oxide-induced crack closure assumptions.

Stuck in the Sump: A Rare Complication of Biliary Surgery.

Sump syndrome is a rare complication of biliary surgery that is now rarely seen in the era of Endoscopic Retrograde Cholangiopancreatography (ERCP). It occurs when the distal common bile duct becomes obstructed between an anastomosis from a choledochoduodenostomy (CDD) and the ampulla of Vater, forming a sump that accumulates debris. Sump syndrome should be considered as a diagnosis in patients who present with cholangitis or pancreatitis and any history of biliary diversion, regardless of the time of presentation.

Supramolecular Entrapping and Extraction of Selenate, Molybdate and Tungstate Ions from Water by Nanojars.

The supramolecular binding exclusively by H-bonds of SeO, MoO and WO ions to form nanojars of the formula [EO⊂{-Cu(μ-OH)(μ-pz)}] (; E = Se, Mo, W; = 28-34; pz = pyrazolate) was studied in solution by electrospray ionization mass spectrometry, variable temperature, paramagnetic H NMR and UV-vis spectroscopy, and in the solid state by single-crystal X-ray crystallography. These large anions allow for the observation of a record nanojar size, (E = Mo, W). Six crystal structures are described of nanojars of varying sizes with either SeO, MoO or WO entrapped ions, including the first example of a cocrystal of two different nanojars in crystallographically unique positions, and .

G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD.

The "secondhit" pathway is responsible for biallelic inactivation of many tumor suppressors, where a pathogenic germline allele is joined by somatic mutation of the remaining functional allele. The mechanisms are unresolved, but the human PKD1 tumor suppressor is a good experimental model for identifying the molecular determinants. Inactivation of PKD1 results in autosomal dominant polycystic kidney disease, a very common disorder characterized by the accumulation of fluid-filled cysts and end-stage renal disease.

Finite mixtures of functional graphical models: Uncovering heterogeneous dependencies in high-dimensional data.

Graphical models have been widely used to explicitly capture the statistical relationships among the variables of interest in the form of a graph. The central question in these models is to infer significant conditional dependencies or independencies from high-dimensional data. In the current literature, it is common to assume that the high-dimensional data come from a homogeneous source and follow a parametric graphical model.

Capnocytophaga Meningitis: A Rare Case of Bacterial Infection With Neurological Manifestation.

We discuss a case of meningitis caused by infection in a previously healthy elderly male who presented with altered mental status and new-onset seizures requiring intensive care. An open wound had served as an entry point for the infectious organism. After 25 days of treatment with meropenem, he recovered with persistent functional limitations and was discharged.

Seizing the Teachable Moment: A Pilot Study of Preventive Lifestyle Education in the Emergency Department.

Background Preventive measures are critical in avoiding and limiting the severity of diseases. Key lifestyle behaviors include sleep hygiene, habitual exercise, a healthy diet, and avoidance of risky substances, particularly the use of tobacco. The transtheoretical model (TTM) of change suggests that patients can move towards healthful changes through education.

Insights into Carvone: Fatty Acid Hydrophobic NADES for Alkane Solubilization.

The urge to adopt cleaner technologies drives the search for novel and sustainable materials such as Hydrophobic Natural Deep Eutectic Solvents (HNADESs), a new class of green solvents characterized by their low toxicity, biodegradability, and tunable properties, aiming to be applied in various fields for handling non-polar substances. In this work, the solubilization of hydrocarbons in type V HNADESs (non-ionic organic molecules) formed by mixing carvone, a natural monoterpenoid, with organic acids (hexanoic to decanoic acids) is examined by applying both experimental and theoretical approaches. The synthesis and physicochemical characterization of different HNADESs allowed us to tailor their properties, aiming for optimal interactions with desired hydrocarbons.

Inclisiran as a siRNA Inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9); Past, Present, and Future.

Reducing low-density lipoprotein cholesterol (LDL-C) levels has been shown to reduce the risk of developing atherosclerotic cardiovascular disease (ASCVD). Statins are the foundation of LDL-C lowering therapy with other non-statin agents used in circumstances where goal LDL-C levels are not reached or owing to intolerance to adverse effects of statins. In 2003, the discovery of the role of the proprotein convertase subtilisin/kexin type 9 (PCSK9) system in promoting elevated LDL-C levels led to new avenues of drug development to achieve target LDL-C.

Case report: HSV lymphadenitis in immunocompromised patient with CLL.

Background: Richter's transformation (RT) in chronic lymphocytic leukemia (CLL) is associated with poor prognosis and requires prompt modifications in patient care. CLL patients are susceptible to severe infections due to immune dysregulation induced by their malignancy and immunosuppressive therapies.

Case Presentation: We present a case of a 63-year-old man with CLL who previously achieved remission and presented with a right inguinal mass.

Gender, Race, and Regional Disparities in Leading Authorships of Gastroenterology and Hepatology Randomized Controlled Trials.

Background And Aims: To investigate gender, racial, ethnic, and regional disparities in first and senior authorship positions in gastroenterology/hepatology-related randomised controlled trials (RCT).

Method: Retrospective bibliometric analysis of PubMed-indexed RCTs published between January 2000 to December 2022 in leading journals with an impact factor of at least five.

Results: 943 RCTs met our inclusion criteria, providing a participant pool of 301 female (15.