Role of topiramate in adults with intractable epilepsy, mental retardation, and developmental disabilities.

The efficacy and safety of topiramate in patients with intractable mixed seizures, mental retardation (MR), and developmental disabilities (DD) were investigated. Twenty patients (eight females and 12 males) aged 21-57 years old with intractable epilepsy with mixed seizures, MR [profound (five), severe (three), moderate (two), mild (eight) and borderline (two)], and DD were treated with adjunctive topiramate 25 mg per day for 1 week followed by titration to clinical response (range 50-350 mg per day). Other antiepileptic drugs (AEDs) were decreased simultaneously.

Analysis of orthodontic anomalies in mentally retarded developmentally disabled (MRDD) persons.

For this epidemiologic study, 458 individuals with mental retardation and developmental disability (MRDD), from 6 to 87 years old, from the Lower Hudson Valley region of New York, were evaluated for the occurrence of orthodontic anomalies. High occurrence of both anomalies of intermaxillary relation, as determined by Angle's classification, and the anomalies of occlusion were found in these individuals when compared with the general population. An increased incidence of both acquired (i.

Developmental disabilities: genetic implications.

Knowledge and new techniques in genetics can aid in a better understanding of developmental disabilities. Through new treatments and better assessment skills, individuals with disorders such as phenylketonuria (PKU), Down syndrome, and fragile X syndrome are having diagnoses sooner and are living into adulthood. With the passage of public law 99.

Antiepileptic drug status in adult outpatients with mental retardation.

Charts of 100 patients with mental retardation and epilepsy from the community were reviewed to survey use of antiepileptic drugs and examine the relation of mental retardation and seizure type to antiepileptic drug status. Sixty patients were on monotherapy and 40, on two or three antiepileptic drugs. Most subjects had generalized tonic-clonic seizures (68%), but there was a trend for those with profound retardation to have relatively more mixed seizures.