Healthcare worker views on antimicrobial resistance in chronic respiratory disease.

Background And Objective: Antimicrobial resistance (AMR) is a global crisis, however, relatively little is known regarding its impact in chronic respiratory disease and the specific challenges faced by healthcare workers across the world in this field. We aimed to assess global healthcare worker views on the challenges they face regarding AMR in chronic respiratory disease.

Methods: An online survey was sent to healthcare workers globally working in chronic respiratory disease through a European Respiratory Society clinical research collaboration (AMR-Lung) focussed on AMR in chronic lung disease.

Regional and institutional trends in assessment for academic promotion.

The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 190 academic institutions and 218 policies from 58 government agencies, covering 32 countries in the Global North and 89 countries in the Global South.

Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health outcomes in female veterans for future intervention success.

Background: Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.

Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.

The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.

BDMANGO: An image dataset for identifying the variety of mango based on the mango leaves.

In the field of agriculture, particularly within the context of machine learning applications, quality datasets are essential for advancing research and development. To address the challenges of identifying different mango leaf types and recognizing the diverse and unique characteristics of mango varieties in Bangladesh, a comprehensive and publicly accessible dataset titled "BDMANGO" has been created. This dataset includes images essential for research, featuring six mango varieties: Amrapali, Banana, Chaunsa, Fazli, Haribhanga, and Himsagar, which were collected from different locations.

Venom immunization: IgG/IgE titers, safety, risk, and methods of the VIPRBITEM cohort.

Background: This is the first study to examine a cohort that engages in the practice of immunization with snake venoms. In this practice, either fresh wet venom or venom reconstituted from freeze-dried form is used in vaccination protocols to produce hyper-immunity to venom.

Methods: This is a retrospective community-initiated collaborative research (CICR) project that collated the records of venom immunization.

Double-stranded RNA orbivirus disrupts the DNA-sensing cGAS-sting axis to prevent type I IFN induction.

Cyclic GMP-AMP synthase (cGAS) is a DNA sensing cellular receptor that induces IFN-I transcription in response to pathogen and host derived cytosolic DNA and can limit the replication of some RNA viruses. Some viruses have nonetheless evolved mechanisms to antagonize cGAS sensing. In this study, we evaluated the interaction between Bluetongue virus (BTV), the prototypical dsRNA virus of the Orbivirus genus and the Sedoreoviridae family, and cGAS.

Rapid and Sustained Resolution of Peristomal Pyoderma Gangrenosum With Aerosol Steroid Treatment.

Background: Peristomal pyoderma gangrenosum (PPG) is a non-infectious neutrophilic dermatosis most commonly seen in the context of ostomies in inflammatory bowel disease. The lack of established treatment guidelines and high-quality evidence in the form of randomized controlled trials present a major challenge in PPG management, owing to the rarity of the condition. Treatment can be further complicated by difficulties in maintaining the stoma pouch seal with conventional topical corticosteroids.

BananaImageBD: A comprehensive banana image dataset for classification of banana varieties and detection of ripeness stages in Bangladesh.

Bananas are among the most widely consumed fruits globally due to their appealing flavor, high nutritional value, and ease of digestion. In Bangladesh, bananas hold significant agricultural importance, being one of the most extensively cultivated fruits in terms of land coverage and ranking third in production volume. The banana image dataset presented in this article includes clear and detailed images of four common banana varieties in Bangladesh: Sagor Kola (), Shabri Kola (), Bangla Kola ( sp.

A programme of support for care assistants of children admitted with cerebral palsy.

Background: Cerebral palsy affects children's movement and posture because of damage to the brain's development. Care assistants in healthcare facilities provide care to children. Caring for the children is overwhelming, hence support is required.

Large-scale evaluation of outcomes after a genetic diagnosis in children with severe developmental disorders.

Purpose: We sought to evaluate outcomes for clinical management after a genetic diagnosis from the Deciphering Developmental Disorders study.

Methods: Individuals in the Deciphering Developmental Disorders study who had a pathogenic/likely pathogenic genotype in the DECIPHER database were selected for inclusion ( = 5010). Clinical notes from regional clinical genetics services notes were reviewed to assess predefined clinical outcomes relating to interventions, prenatal choices, and information provision.

Silica-Activated Redox Signaling Confers Rice with Enhanced Drought Resilience and Grain Yield.

Under a changing climate, enhancing the drought resilience of crops is critical to maintaining agricultural production and reducing food insecurity. Here, we demonstrate that seed priming with amorphous silica (SiO) nanoparticles (NPs) (20 mg/L) accelerated seed germination speed, increased seedlings vigor, and promoted seedling growth of rice under polyethylene glycol (PEG)-mimicking drought conditions. An orthogonal approach was used to uncover the mechanisms of accelerated seed germination and enhanced drought tolerance, including electron paramagnetic resonance, Fourier transform infrared spectroscopy (FTIR), metabolomics, and transcriptomics.

Anterior Cruciate Ligament Injuries: A Review of Quality and Reliability of Online Information.

Aim This study aims to evaluate the reliability and quality of online information on anterior cruciate ligament (ACL) injuries. Methods An internet search on the three top search engines, Google, Yahoo!, and Bing, was done using the keywords "anterior cruciate ligament injury". The search was carried out in June 2023, and 39 websites were selected.

Density, Speed of Sound, Refractive Index, and the Derived Properties of Binary Mixtures of ,-Dimethylacetamide with 1-Butanol, 1-Pentanol, Furfural, or Furfuryl Alcohol at Different Temperatures.

The density (ρ), speed of sound (), and refractive index ( ) of ,-dimethylacetamide (DMA) with 1-butanol, 1-pentanol, furfural (FFL), or furfuryl alcohol (FA) as a function of composition and at = 293.15 to 323.15 K with an interval of 10 K and atmospheric pressure were measured.

The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.

Multiple Sclerosis (MS), a debilitating inflammatory disorder of the central nervous system characterized by demyelination, is significantly influenced by polygenic variations. Although the precise cause of MS remains unclear, it is believed to arise from a complex interplay of genetic and environmental factors. Recent investigations have focused on the polygenic nature of genetic alterations linked to MS risk.

Randomized Comparison of Magnetic Resonance Imaging Versus Transurethral Resection for Staging New Bladder Cancers: Results From the Prospective BladderPath Trial.

Purpose: Transurethral resection of bladder tumor (TURBT) is the initial staging procedure for new bladder cancers (BCs). For muscle-invasive bladder cancers (MIBCs), TURBT may delay definitive treatment. We investigated whether definitive treatment can be expedited for MIBC using flexible cystoscopic biopsy and multiparametric magnetic resonance imaging (mpMRI) for initial staging.

Enhanced Efficiency of Anionic Guerbet-Type Amino Acid Surfactants.

This study investigates the surfactant properties and efficiency of linear and Guerbet-type amino acid surfactants. Utilizing a Wilhelmy plate method, we assessed the colloidal efficiency of these surfactants, with the lowest observed critical micelle concentration at 0.046 mmol L, significantly reducing surface tension to as low as 25.

Corrigendum: Mental health review board members' understanding of the policy guideline on 72-hour assessment.

No abstract available.

Tenascin-X deficiency causing classical-like Ehlers Danlos syndrome type 1 in humans is a significant risk factor for GI and tracheal ruptures.

Background: Classical-like Ehlers Danlos Syndrome type 1 (clEDS1) is a very rare form of Ehlers Danlos Syndrome (EDS) caused by tenascin-X (TNX) deficiency, with only 56 individuals reported. TNX is an extracellular matrix protein needed for collagen stability. Previous publications propose that individuals with clEDS1 might be at risk for gastrointestinal (GI) tract perforations and/or tracheal ruptures.

Biochar for ameliorating soil fertility and microbial diversity: From production to action of the black gold.

This article evaluated different production strategies, characteristics, and applications of biochar for ameliorating soil fertility and microbial diversity. The biochar production techniques are evolving, indicating that newer methods (including hydrothermal and retort carbonization) operate with minimum temperatures, yet resulting in high yields with significant improvements in different properties, including heating value, oxygen functionality, and carbon content, compared to the traditional methods. It has been found that the temperature, feedstock type, and moisture content play critical roles in the fabrication process.

The CeHRes Roadmap 2.0: Update of a Holistic Framework for Development, Implementation, and Evaluation of eHealth Technologies.

To ensure that an eHealth technology fits with its intended users, other stakeholders, and the context within which it will be used, thorough development, implementation, and evaluation processes are necessary. The CeHRes (Centre for eHealth and Wellbeing Research) Roadmap is a framework that can help shape these processes. While it has been successfully used in research and practice, new developments and insights have arisen since the Roadmap's first publication in 2011, not only within the domain of eHealth but also within the different disciplines in which the Roadmap is grounded.

Remotely-Sensed Game Trails Are a Behavioral Footprint That Explains Patterns of Herbivore Habitat Use.

Trade-offs between food acquisition and predator avoidance shape the landscape-scale movements of herbivores. These movements create landscape features, such as game trails, which are paths that animals use repeatedly to traverse the landscape. As such, these trails integrate behavioral trade-offs over space and time.

First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study.

Introduction: SCLC is characterized by aggressiveness and limited treatment options, especially in extensive-stage SCLC (ES-SCLC). Immunotherapy added to the platinum-etoposide combination has recently become standard in this setting. This retrospective study aims to evaluate the real-world effectiveness of chemo-immunotherapy in patients with ES-SCLC, focusing on subpopulations excluded from clinical trials.

Special Issue on Nanoparticles in Nanobiotechnology and Nanomedicine.

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An Evolutionary Federated Learning Approach to Diagnose Alzheimer's Disease Under Uncertainty.

Alzheimer's disease (AD) leads to severe cognitive impairment and functional decline in patients, and its exact cause remains unknown. Early diagnosis of AD is imperative to enable timely interventions that can slow the progression of the disease. This research tackles the complexity and uncertainty of AD by employing a multimodal approach that integrates medical imaging and demographic data.