Therapeutic potential of targeting IRES-dependent c-myc translation in multiple myeloma cells during ER stress.

Protein translation is inhibited by the unfolded protein response (UPR)-induced eIF-2α phosphorylation to protect against endoplasmic reticulum (ER) stress. In addition, we found additional inhibition of protein translation owing to diminished mTORC1 (mammalian target of rapamycin complex1) activity in ER-stressed multiple myeloma (MM) cells. However, c-myc protein levels and myc translation was maintained.

Dominant posterior-variant alien hand syndrome after acute left parietal infarction.

Alien hand syndrome (AHS) is a complex clinical disorder in which patients develop a sense of estrangement from, and loss of volitional control of, an affected limb and non-purposeful complex motor actions of the same limb. Several forms of AHS exist, including frontal, callosal, and posterior types with a series of different associated neuroanatomical lesions and clinical symptoms. Most commonly, the lesions associated with AHS occur in the frontal lobes and corpus callosum.