Micro-RNA335-5p targeted inhibition of and promoted oxidative stress-mediated aging of endothelial cells.

MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit . This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho. The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with HO.