3 results match your criteria: "Wellman Center for Photomedicine Massachusetts General Hospital Boston[Affiliation]"
Background Neutrophils are thought to be short-lived first responders to tissue injuries such as myocardial infarction (MI), but little is known about their diversification or dynamics. Methods and Results We permanently ligated the left anterior descending coronary arteries of mice and performed single-cell RNA sequencing and analysis of >28 000 neutrophil transcriptomes isolated from the heart, peripheral blood, and bone marrow of mice on days 1 to 4 after MI or at steady-state. Unsupervised clustering of cardiac neutrophils revealed 5 major subsets, 3 of which originated in the bone marrow, including a late-emerging granulocyte expressing SiglecF, a marker classically used to define eosinophils.
View Article and Find Full Text PDFAm J Phys Med Rehabil
January 2018
Laboratory of Electrothermophototherapy Department of Physical Therapy Federal University of São Carlos São Carlos, São Paulo, Brazil, Post-Graduation Program in Biotechnology Federal University of São Carlos São Carlos, São Paulo, Brazil Optics Group Physics Institute of São Carlos University of São Paulo São Carlos, São Paulo, Brazil, Wellman Center for Photomedicine Massachusetts General Hospital Boston, Massachusetts and Department of Physical Therapy Universidade do Sagrado Coração - USC Bauru, Sâo Paulo, BrazilDepartment of Physiological Sciences Federal University of São Carlos São Carlos, São Paulo, BrazilFaculty of Medicine University of São Paulo Ribeirão Preto, São Paulo, Brazil and Center for Cell Therapy and Regional Blood Center of Ribeirão Preto São Paulo, BrazilDepartment of Medicine Federal University of São Carlos São Carlos, São Paulo, BrazilFaculty of Medicine University of São Paulo Ribeirão Preto, São Paulo, Brazil and Center for Cell Therapy and Regional Blood Center of Ribeirão Preto São Paulo, BrazilFaculty of Medicine University of São Paulo Ribeirão Preto, São Paulo, Brazil and Center for Cell Therapy and Regional Blood Center of Ribeirão Preto São Paulo, BrazilPost-Graduation Program in Biotechnology Federal University of São Carlos São Carlos, São Paulo, BrazilDepartment of Genetic and Evolution Federal University of São Carlos São Carlos, São Paulo, BrazilPost-Graduation Program in Bioengineering University of São Paulo São Carlos, São Paulo, BrazilWellman Center for Photomedicine Massachusetts General Hospital Boston, Massachusetts Department of Dermatology Harvard Medical School Boston, Massachusetts and Harvard-MIT Division of Health Sciences and Technology Cambridge, MassachusettsLaboratory of Electrothermophototherapy Department of Physical Therapy Federal University of São Carlos São Carlos, São Paulo, Brazil and Post-Graduation Program in Biotechnology Federal University of São Carlos São Carlos, São Paulo, BrazilOptics Group Physics Institute of Sao Carlos University of São Paulo São Carlos, São Paulo, Brazil.
Photodynamic therapy (PDT) was discovered over one hundred years ago when it was observed that certain dyes could kill microorganisms when exposed to light in the presence of oxygen. Since those early days, PDT has mainly been developed as a cancer therapy and as a way to destroy proliferating blood vessels. However, recently it has become apparent that PDT may also be used as an effective antimicrobial modality and a potential treatment for localized infections.
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