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67 results match your criteria: "Wellcome Trust Centre for Global Health Research[Affiliation]"
Intensive Care Med Exp
November 2024
Critical Care Research Group, The Prince Charles Hospital, Level 3, Clinical Sciences Building, Chermside Qld 4032, Brisbane, QLD, Australia.
Intensive Care Med Exp
October 2024
Critical Care Research Group, The Prince Charles Hospital, 627 Rode Road, Level 3 Clinical Sciences Building, Chermside, Brisbane, QLD, 4032, Australia.
J Cardiothorac Surg
August 2024
Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Background: Packed red blood cell (pRBC) transfusion is a relatively safe and mainstay treatment commonly used in cardiac surgical patients. However, there is limited evidence on clinical effects of transfusing blood nearing end-of shelf life that has undergone biochemical changes during storage.
Objective: To investigate evidence of associations between morbidity/mortality and transfusion of blood near end of shelf-life (> 35 days) in cardiac surgical patients.
Front Cardiovasc Med
July 2024
Department of Cardiology, The Prince Charles Hospital, Brisbane, QLD, Australia.
Eur J Clin Invest
October 2024
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Eur J Clin Invest
October 2024
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Background: The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI.
View Article and Find Full Text PDFAdv Physiol Educ
September 2024
East African Society of Physiological Sciences, East Africa Region, Rwanda.
Syst Rev
November 2023
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Eur J Clin Invest
February 2024
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Int J Gynaecol Obstet
January 2024
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
Artif Organs
October 2023
The Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Front Cardiovasc Med
May 2023
Critical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane, QLD, Australia.
The right ventricle (RV) has a critical role in hemodynamics and right ventricular failure (RVF) often leads to poor clinical outcome. Despite the clinical importance of RVF, its definition and recognition currently rely on patients' symptoms and signs, rather than on objective parameters from quantifying RV dimensions and function. A key challenge is the geometrical complexity of the RV, which often makes it difficult to assess RV function accurately.
View Article and Find Full Text PDFJ Heart Lung Transplant
August 2023
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Background: The global shortage of donor hearts available for transplantation is a major problem for the treatment of end-stage heart failure. The ischemic time for donor hearts using traditional preservation by standard static cold storage (SCS) is limited to approximately 4 hours, beyond which the risk for primary graft dysfunction (PGD) significantly increases. Hypothermic machine perfusion (HMP) of donor hearts has been proposed to safely extend ischemic time without increasing the risk of PGD.
View Article and Find Full Text PDFCrit Care
March 2023
Critical Care Research Group, The Prince Charles Hospital, University of Queensland, Brisbane, QLD, Australia.
Crit Care Med
May 2023
Department of Cardiology, Tan Tock Seng Hospital, Singapore.
Objectives: To determine the prevalence and outcomes associated with hemorrhage, disseminated intravascular coagulopathy, and thrombosis (HECTOR) complications in ICU patients with COVID-19.
Design: Prospective, observational study.
Setting: Two hundred twenty-nine ICUs across 32 countries.
SSM Popul Health
September 2022
Epidemiology and Control of Infectious Diseases, Department of Microbiology and Parasitology, University of Buea, PO Box 63, Buea, Cameroon.
Background: Podoconiosis and leprosy are Neglected Tropical Diseases associated with low quality of life, social stigma and isolation of affected people and families. Despite the substantial social burden it imposes, podoconiosis has largely been ignored in the global health literature until recently unlike leprosy. This study assessed and compared the quality of life and social impact of podoconiosis with that of leprosy among affected households and neighborhoods in North West Cameroon.
View Article and Find Full Text PDFCrit Care Explor
April 2022
Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Unlabelled: This narrative review aims to discuss the potential applicability of speckle-tracking echocardiography (STE) in patients under mechanical ventilation (MV) and mechanical circulatory support (MCS). Both its benefits and limitations were considered through critical analyses of the current available evidence.
Data Sources And Study Selection: A literature search was conducted in PubMed and Excerpta Medica Database indexed databases (2012-2021).
BMC Cardiovasc Disord
March 2022
Section of Cardiac Surgery, Department of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Background: The influence of renin-angiotensin-aldosterone system (RAAS) inhibitors on the critically ill COVID-19 patients with pre-existing hypertension remains uncertain. This study examined the impact of previous use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) on the critically ill COVID-19 patients.
Methods: Data from an international, prospective, observational cohort study involving 354 hospitals spanning 54 countries were included.
Intensive Care Med Exp
December 2021
Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Background: Heart transplantation (HTx) from brainstem dead (BSD) donors is the gold-standard therapy for severe/end-stage cardiac disease, but is limited by a global donor heart shortage. Consequently, innovative solutions to increase donor heart availability and utilisation are rapidly expanding. Clinically relevant preclinical models are essential for evaluating interventions for human translation, yet few exist that accurately mimic all key HTx components, incorporating injuries beginning in the donor, through to the recipient.
View Article and Find Full Text PDFPhysiol Rep
October 2021
Critical Care Research Group, The Prince Charles Hospital, Brisbane, Australia.
The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub-phenotypes that exist within its broader envelope. These sub-phenotypes have varied outcomes and respond differently to several previously studied interventions.
View Article and Find Full Text PDFGlobal Health
July 2021
Faculty of Medicine, University of Queensland, Brisbane, Australia.
Background: The initial research requirements in pandemics are predictable. But how is it possible to study a disease that is so quickly spreading and to rapidly use that research to inform control and treatment?
Main Body: In our view, a dilemma with such wide-reaching impact mandates multi-disciplinary collaborations on a global scale. International research collaboration is the only means to rapidly address these fundamental questions and potentially change the paradigm of data sharing for the benefit of patients throughout the world.
Pharmacol Res
July 2021
Critical Care Research Group, The Prince Charles Hospital, Queensland, Australia; School of Medical Sciences, Griffith University, Queensland, Australia; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Australia; Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Australia; Cardiothoracic Surgery and Transplantation, The Alfred Hospital, and Monash University, Melbourne, Australia.
Background: Heart failure is an inexorably progressive disease with a high mortality, for which heart transplantation (HTx) remains the gold standard treatment. Currently, donor hearts are primarily derived from patients following brain stem death (BSD). BSD causes activation of the sympathetic nervous system, increases endothelin levels, and triggers significant inflammation that together with potential myocardial injury associated with the transplant procedure, may affect contractility of the donor heart.
View Article and Find Full Text PDFAm J Respir Crit Care Med
August 2020
Critical Care Research Group, the Prince Charles Hospital, Brisbane, Queensland, Australia.
Mesenchymal stromal cell (MSC) therapy is a promising intervention for acute respiratory distress syndrome (ARDS), although trials to date have not investigated its use alongside extracorporeal membrane oxygenation (ECMO). Recent preclinical studies have suggested that combining these interventions may attenuate the efficacy of ECMO. To determine the safety and efficacy of MSC therapy in a model of ARDS and ECMO.
View Article and Find Full Text PDFTransplantation
November 2020
Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Despite advances in mechanical circulatory devices and pharmacologic therapies, heart transplantation (HTx) is the definitive and most effective therapy for an important proportion of qualifying patients with end-stage heart failure. However, the demand for donor hearts significantly outweighs the supply. Hearts are sourced from donors following brain death, which exposes donor hearts to substantial pathophysiological perturbations that can influence heart transplant success and recipient survival.
View Article and Find Full Text PDFFront Pediatr
January 2020
Critical Care Research Group, The Prince Charles Hospital, Chermside, QLD, Australia.
[This corrects the article DOI: 10.3389/fped.2018.
View Article and Find Full Text PDF