IRE1α-XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs.

Hematopoietic stem cells must mitigate myriad stressors throughout their lifetime to ensure normal blood cell generation. Here, we uncover unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells (HSPCs) as a safeguard against myeloid leukemogenesis. Activated in part by an NADPH oxidase-2 mechanism, IRE1α-induced X-box binding protein-1 (XBP1) mediated repression of pro-leukemogenic programs exemplified by the Wnt-β-catenin pathway.

Physicochemical and functional properties of cinnamon essential oil emulsions stabilized by galactomannan-rich aqueous extract from Gleditsia sinensis seeds and soy protein isolate.

Cinnamon essential oil has gained widespread attention in the food industry as a safe and effective preservative. However, its low water solubility and high volatility limit its application in food, making the use of natural emulsifiers for its emulsification an increasingly popular focus of research. This study focuses on the extraction of galactomannan-rich aqueous extracts from Gleditsia sinensis seeds using a low-energy, low-pollution microwave-assisted method.

Biofilm development as a factor driving the degradation of plasticised marine microplastics.

Biodegradation of microplastics facilitated by natural marine biofouling is a promising approach for ocean bioremediation. However, implementation requires a comprehensive understanding of how interactions between the marine microbiome and dominant microplastic debris types (e.g.

The transport, distribution, and budget of anthropogenic I in the Bohai and North Yellow Seas, China.

The potential release of radionuclides threatens marine ecosystems with the rapid development of coastal nuclear power plants in China. However, transport, dispersion, and final budget of anthropogenic radionuclides remain unclear, especially in the Bohai and North Yellow Seas, which are semi-enclosed marginal seas with poor water exchange. This study analyzed anthropogenic I concentration (a typical product of nuclear power plant operations) in seawater samples from this area.

Integrating processing factors and large-scale cabbage cultivation to understand the fate tendency and health risks of tolfenpyrad using deterministic and probabilistic models.

Understanding the negative effects of agrochemicals on the environment and human health is indispensable for achieving green agriculture. In this study, the optimized UHPLC-MS/MS method achieved a highly sensitive quantification of tolfenpyrad in cabbage within 4.04 min.

Insights into plutonium in marine biota along the coast of China.

Radiation risk through seafood consumption is a big public concern under the discharge of nuclear contaminated water. Plutonium is an important radionuclide in view of radiation risk due to its high radiological and chemical toxicity, as well as consistent presence in the environment. The distribution and level of plutonium isotopes (Pu, Pu) in marine biota collected along the coast of China in 2022-2023 were investigated.

Chlorination-induced spread of antibiotic resistance genes in drinking water systems.

Chlorine, the most widely utilized disinfectant for drinking water globally, has recently been implicated in facilitating the spread of antibiotic resistance genes (ARGs), raising concerns about its underestimated environmental and ecological risks. However, given the current fragmented research focus and results, a comprehensive understanding of the potential mechanisms and influencing factors behind chlorination-promoted ARGs transmission in drinking water systems is crucial. This work is the first to systematically review the variations in abundance, transmission mechanisms, influencing factors, and mitigation strategies related to ARGs during the chlorination process.

Harnessing the dynamics of plant organic acids metabolism following abiotic stresses.

Plants encounter various environmental stresses throughout development, including shade, high light, drought, hypoxia, extreme temperatures, and metal toxicity, all of which adversely affect growth and productivity. Organic acids (OAs), besides serving as intermediates in the tricarboxylic acid (TCA) cycle, play crucial roles in multiple metabolic pathways and cellular compartments, including mitochondrial metabolism, amino acid metabolism, the glyoxylate cycle, and the photosynthetic mechanisms of C4 and CAM plants. OAs contribute to stress tolerance by acting as root chelating agents, regulating ATP production, and providing reducing power for detoxifying reactive oxygen species (ROS).

Hybrid Pennisetum colonization by Bacillus megaterium BM18-2 labeled with green fluorescent protein (GFP) under Cd stress.

Researchers have reported that Bacillus megaterium BM18-2 reduces Cd toxicity in Hybrid Pennisetum, but understanding the interaction between plants and associated endophytes is crucial for understanding phytoremediation strategies under heavy metal stress. The current study aims to monitor the colonization patterns of GFP-labeled endophytic bacteria BM18-2 on Hybrid Pennisetum grass. Additionally, it will monitor Cd's effect on plant bacterial colonization.

Experimental investigation into the Impact of Cyclic High Low Pressure Water Immersion on the Pore structure and Mechanical properties of coal.

The extraction of coal seams with high gas content and low permeability presents significant challenges, particularly due to the extended period required for gas extraction to meet safety standards and the inherently low extraction efficiency. Hydraulic fracturing technology, widely employed in the permeability enhancement of soft and low-permeability coal seams, serves as a key intervention. This study focuses on the high-rank raw coal from the No.

Optimizing concrete sustainability with bagasse ash and stone dust and its impact on mechanical properties and durability.

Addressing environmental challenges such as pollution and resource depletion requires innovative industrial and municipal waste management approaches. Cement production, a significant contributor to greenhouse gas emissions, highlights the need for eco-friendly building materials to combat global warming and promote sustainability. This study evaluates the simultaneous use of Sugarcane Bagasse Ash (SCBA) and Stone Dust (SD) as partial replacements by volume for cement and sand, respectively, at varying ratios in eco-strength concrete mixes designed for 28 MPa (ES-28) and 34 MPa (ES-34), emphasizing their economic and environmental benefits.

Rational designing of ZIF-67-derived CoO nanocomposite with hierarchical porous structure and extensive peroxidase mimetic activities for highly sensitive colorimetric detection of nitrite in drinking water.

A simple, fast, and cost-effective colorimetric nitrite (NO) sensor based on ZIF-67-derived CoO nanocomposite (ZCo-2 NC) structure has been developed. The prepared colorimetric sensor (ZCo-2 NC) was employed to sensitively detect NO in drinking water system by the exhibition of promising peroxidase-mimicking nanozyme-like features. The sensor manifest well-determined sensing response with excellent linear and wide range of NO sensitivity (0.

Gellan-amino acid hydrogel-based bioreactor for optimizing the production of yeast metabolites.

Hydrogels mimic natural environments due to their hydrated, polymeric networks which are beneficial for microorganism growth. The substantial water content maintains a consistently moist environment, and porous structure of hydrogel promotes efficient nutrient transfer and cell distribution, offering advantages over traditional liquid bioreactors. While their application in cell immobilization for bioconversion is well-known, their use as a solid-state fermentation matrix remains unexplored.

Cellulose nanofiber-created air barrier enabling closed-cell foams prepared via oven-drying.

Cellulose foams are renewable and biodegradable materials that are promising substitutes for plastic foams. However, the scale-up fabrication of cellulose foams is severely hindered by technological complexity and cost- and time-consuming drying processes. Here, we developed a facile and robust method to fabricate cellulose foams via oven-drying following surfactant-assisted mechanical foaming of cellulose nanofibers (CNFs).

Polymeric saccharides: Effect on physical characteristics and creaminess perception of non-fat whipped cream analogue.

In this study, the improvement effects of different polymeric saccharides, including native starch, maltodextrin and inulin, replacing 10 % sucrose on the physical characteristics and creaminess perception of non-fat whipped cream system were investigated. Systems containing maltodextrin had more uniform particle size and bubble distribution. This resulted in higher whipping performance and lower friction characteristics.

Oil recovery and heat transfer performance of polyurethane sponges coated with 3D carbon nano networks.

Heatable super hydrophobic polyurethane (PU) sponges (S-GNS/CNT/PVA@PU) containing three-dimensional (3D) carbon nano-networks (CNNs) coatings made from two-dimensional (2D) expanded graphite nano-sheets (GNS) bridged by one-dimensional (1D) carbon nano-tubes (CNT) were constructed using polyvinyl alcohol (PVA) as binder, in which light and/or electric energy could be rapidly converted into heat to reduce the viscosity of spilled heavy oils, resulting in greatly increased oil. Their heavy oil recovery rate could reach 792 kg/(m·h) under combined light and Joule heating of 1 sun and 5 V. Surface heat dissipating coefficient Ks, heat dissipating index n, and surface heat absorption capacity Cs were studied relating to sizes and shapes of surface heating fields under varied heating modes.

17α-methyltestosterone exposure disrupted growth, liver physiology and intestinal microbial on fish: A case study on migratory bony fishes (Takifugu fasciatus).

17α-methyltestosterone (17α-MT) is prevalent in the aqueous environment, but its toxicological profile remains incomplete. This study analyzed the effects of different 17α-MT concentrations on the growth performance, mortality, sex ratio, liver physiological metabolism, and intestinal microorganisms of Takifugu fasciatus, and on the microorganisms composition of its culture environment. Results showed that 17α-MT increased the male ratio and mortality but inhibited the growth of T.

Synergistic Atomic Environment Optimization of Nickel-Iron Dual Sites by Co Doping and Cr Vacancy for Electrocatalytic Oxygen Evolution.

The dual-site synergistic catalytic mechanism on NiFeOOH suggests weak adsorption of Ni sites and strong adsorption of Fe sites limited its activity toward alkaline oxygen evolution reaction (OER). Large-scale density functional theory (DFT) calculations confirm that Co doping can increase Ni adsorption, while the metal vacancy can reduce Fe adsorption. The combined two factors can further modulate the atomic environment and optimize the free energy toward oxygen-containing intermediates, thus enhancing the OER activity.

Protein Based Hybrid Materials of Metal Phosphate Nanoflowers and Gels for Water Remediation: Perspectives and Prospects.

Water pollution is a critical environmental issue affecting ecosystems and human health worldwide. Contaminants such as heavy metals, dyes, antibiotics, and microplastics enter water bodies from the disposals of industrial, agricultural, and domestic waste. The development of new and advanced technologies for addressing water remediation has turned out to be a dire need.

Tunable NiSe-NiSe Heterojunction for Energy-Efficient Hydrogen Production by Coupling Urea Degradation.

Urea-assisted water splitting is a promising energy-saving hydrogen (H) production technology. However, its practical application is hindered by the lack of high-performance bifunctional catalysts for urea oxidation reaction (UOR) and hydrogen evolution reaction (HER). Herein, a heterostructured catalyst comprising highly active NiSe and NiSe, along with a conductive graphene-coated nickel foam skeleton (NiSe-NiSe/GNF) is reported.

Canopy elastic turbulence: Insights and analogies to canopy inertial turbulence.

Canopy flows occur when a moving fluid encounters a matrix of free-standing obstacles and are found in diverse systems, from forests and marine ecology to urban landscapes and biology (e.g. cilia arrays).

Chemodynamic covalent adaptable network-induced robust, self-healing, and degradable fluorescent elastomers for multicolor information encryption.

Elastomers are of great significance in developing smart materials for information encryption, and their unique self-healing and highly flexible properties provide innovative solutions to enhance security and anti-counterfeiting effectiveness. However, challenges remain in the multifunctional combination of mechanical properties, self-healing, degradability, and luminescence of these materials. Herein, a chemodynamic covalent adaptable network (CCAN)-induced robust, self-healing, and degradable fluorescent elastomer is proposed.

Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.

The cGAS-STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cGAS-STING pathway. Herein, Mn galvanic cells (MnG) are prepared via liquid-phase exfoliation and in situ galvanic replacement to modulate tumor metabolism, thereby enhancing cGAS-STING activation for bidirectional synergistic H-immunotherapy.

Multi-dimensional scaling for space-time transformation to achieve sustainable planning and management of water resource under changing land use pattern.

The land use transition plays an important role for terrestrial environmental services, which had a mixed impact of positive and negative on the groundwater and terrestrial water resource. The health of ecological systems and groundwater depends on the mapping and management of land use. The Ganga basin is one of the most densely populated and agriculture-intensive river systems in the South Asia and the world.

Insights into the photocatalytic removal of malachite green organic pollutant by highly efficient hard responsive BaCoDyFeO catalysts.

The widespread discharge of organic dyes into the wastewater from various industrial processes has develop a major environmental apprehension in the modern world. To tackle such environmental issues, we are synthesizing a novel catalyst of composition, BaCoDyFeO (x = y = 0.02-0.