2 results match your criteria: "Washington University School of Medicine (J.W.[Affiliation]"
Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator.
J Pharmacol Exp Ther
October 2024
Department of Internal Medicine (Pharmacogenomics), Washington University School of Medicine (J.W., L.Z., A.F., E.C., G.W.D.) and Mitochondria in Motion, Inc. (J.W., L.Z.), St. Louis Missouri
Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of preclinical models are uncertain. Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2 A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse.
View Article and Find Full Text PDFAutoimmune Diseases in Children and Adults With Type 1 Diabetes From the T1D Exchange Clinic Registry.
J Clin Endocrinol Metab
December 2016
Department of Medicine, Washington University School of Medicine (J.W.H., J.B.M.), St Louis, Missouri 63110; Jaeb Center for Health Research (T.D.R., K.M.M.), Tampa, Florida 33647; Department of Pediatrics, Indiana University School of Medicine (L.A.D.), Indianapolis, Indiana 46202; and Department of Medicine, Perelman School of Medicine (M.R.R.) University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Background And Aims: Type 1 diabetes (T1D) is associated with other autoimmune diseases (AIDs), but the prevalence and associated predictive factors for these comorbidities of T1D across all age groups have not been fully characterized.
Materials And Methods: Data obtained from 25 759 participants with T1D enrolled in the T1D Exchange Registry were used to analyze the types and frequency of AIDs as well as their relationships to gender, age, and race/ethnicity. Diagnoses of autoimmune diseases, represented as ordinal categories (0, 1, 2, 3, or more AIDs) were obtained from medical records of Exchange Registry participants.