31,927 results match your criteria: "Wash; Seattle Children's Research Institute[Affiliation]"

Evaluating point source pesticide contamination via sprayer washing water dispersal: A northern Italian vineyard area case study.

Sci Total Environ

January 2025

European Observatory on sustainable agriculture (OPERA), Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122, Piacenza, (PC), Italy; Università Cattolica del Sacro Cuore, Department for Sustainable Food Process, Via Emilia Parmense 84, 29122, Piacenza, (PC), Italy. Electronic address:

Wastewater contaminated by plant protection products (PPP) from sprayer cleaning operations must be properly managed and disposed of, as it could represent a point source of environmental PPP pollution and pose risks to non-target organisms. Three conventionally and two organically managed farms in hilly vineyards of North-West Italy engaged in a participatory activity for sampling sprayer washing and resultant water. In total 52 samples of wash water (internal and external) were collected during two agricultural seasons and analyzed for six organic pesticides and metallic Cu.

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Glucocorticosteroids remain the most common pharmaceutical approach for the treatment of equine asthma but can be associated with significant side effects, including respiratory microbiome alterations. The goal of the study was to assess the impact of 2% lidocaine nebulization, a projected alternative treatment of equine asthma, on the healthy equine respiratory microbiota. A prospective, randomized, controlled, blinded, 2-way crossover study was performed, to assess the effect of 1 mg/kg 2% lidocaine (7 treatments over 4 days) on the equine respiratory microbiota compared to control horses (saline and no treatment).

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Evaluation of Nanomagnetite-Biochar Composite for BTA Removal.

Nanomaterials (Basel)

January 2025

ISTerre, University Grenoble Alpes, University Savoie Mont Blanc, CNRS, IRD, University Gustave Eiffel, 38058 Grenoble, France.

In this study, the removal of benzotriazole (BTA), a pervasive aquatic contaminant widely used for its anti-corrosion, UV-stabilizing, and antioxidant properties, by nanomagnetite, biochar, and nanomagnetite-biochar composite is investigated. Nanomagnetite and nanomagnetite-biochar composite were synthesized under anoxic conditions and tested for BTA removal efficiency at neutral pH under both oxic and anoxic conditions at different time scales. Within the short time scale (up to 8 h), the removal of BTA by nanomagnetite-biochar composite was shown to be due to BTA deprotonation by the nanomagnetite surface.

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Endodontic therapy aims at preventing or curing apical periodontitis. To conduct this, the cleaning and shaping of the canals are essential. By using an irrigant, such as sodium hypochlorite (NaOCl), practitioners attempt to wash out debris, dissolve organic and inorganic tissue, lubricate the canals, prevent smear layer formation, and disrupt biofilms.

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Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors.

Eng Life Sci

January 2025

Analytical Development & Analytical Attribute Science in Biologics Bristol Myers Squibb Devens Massachusetts USA.

This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon-γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, potency, and overall clinical performance due to its influence on protein clearance via hepatic asialoglycoprotein receptors (ASGPR). The ASGPR recognizes and binds to glycoproteins exposed to terminal galactose or N-acetylgalactosamine residues, leading to receptor-mediated endocytosis. Recent studies have demonstrated that sialylation of O-linked glycan plays a role in protecting against macrophage galactose lectin (MGL)-mediated clearance.

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Biosynthesis of Lysosomally Escaped Apoptotic Bodies Inhibits Inflammasome Synthesis in Macrophages.

Research (Wash D C)

January 2025

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P. R. China.

Hyperglycemia and bacterial colonization in diabetic wounds aberrantly activate Nod-like receptor protein 3 (NLRP3) in macrophages, resulting in extensive inflammatory infiltration and impaired wound healing. Targeted suppression of the NLRP3 inflammasome shows promise in reducing macrophage inflammatory disruptions. However, challenges such as drug off-target effects and degradation via lysosomal capture remain during treatment.

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Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective.

Research (Wash D C)

January 2025

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.

Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. Increasing evidence unravel the intricate role of gut microbiota in reshaping tumor microenvironment and affecting the efficacy and toxicities of immunotherapy, which shed more light on the future applications of gut microbiota in efficacious biomarker and combination treatment of immunotherapy. To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.

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Introduction: Cholera outbreaks remain persistent in the WHO African region, with an increased trend in recent years. This study analyses actual drivers of cholera including correlations with water, sanitation, and hygiene (WASH) indicators, and climate change trends.

Methods: This was a cross-sectional descriptive and analytic study.

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Chitosan- and sodium alginate-coated dendritic mesoporous organosilica nanoparticles improve pesticide adhesion on leaves and enable dual-stimulus-responsive release.

Int J Biol Macromol

January 2025

Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address:

During the application of most conventional pesticides, a significant proportion is lost through rain wash-off and leaf rolling, leading to reduced actual utilization efficiency. In this paper, aminated dendritic mesoporous organosilicon nanoparticles (DMONs-NH) were synthesized via a one-pot method and used as carriers. Carbendazim (CBZ) was then encapsulated within DMONs-NH through hydrogen bonding and electrostatic interactions.

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Disseminated Cysticercosis.

Radiographics

February 2025

From the Department of Radiology, Hong Kong Children's Hospital, Kowloon Bay, Hong Kong (K.F.K.F.); Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada (K.F.K.F.); Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (I.D.d.O.S.); Department of Radiology, Division of Musculoskeletal and Intervention, University of Washington, Seattle, Wash (A.P.); Department of Radiology, Bai Jerbai Wadia Hospital for Children, Mumbai, India (F.G.); and Division of Body Imaging, Department of Radiology, University of Iowa Health Care, Iowa City, Iowa (Y.A.).

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Blastocystis, an eukaryote, inhabits the intestinal tract of humans and animals worldwide. Lactobacillus acidophilus (L. acidophilus), a probiotic, has been reported to be effective against blastocystosis.

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Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation.

Research (Wash D C)

January 2025

Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People's Republic of China.

Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate cell behavior and reduce the incidence of fibrosis, in the field of ophthalmic implants, especially the modification and effects of hydrogel micropatterns have rarely been reported.

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Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. In this research, expression and prognostic values of exercise-responsive miRNAs were examined in breast cancer (BRCA) and further pan-cancer types. In addition, multiple independent public and in-house cohorts, in vitro assays involving multiple, macrophages, fibroblasts, and tumor cells, and in vivo models were utilized to uncover the tumor-suppressive roles of miR-29a-3p in cancers.

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Terahertz Science and Technology in Astronomy, Telecommunications, and Biophysics.

Research (Wash D C)

January 2025

Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210023, China.

This paper reviews recent developments and key advances in terahertz (THz) science, technology, and applications, focusing on 3 core areas: astronomy, telecommunications, and biophysics. In THz astronomy, it highlights major discoveries and ongoing projects, emphasizing the role of advanced superconducting technologies, including superconductor-insulator-superconductor (SIS) mixers, hot electron boundedness spectroscopy (HEB), transition-edge sensors (TESs), and kinetic inductance detectors (KIDs), while exploring prospects in the field. For THz telecommunication, it discusses progress in solid-state sources, new communication technologies operating within the THz band, and diverse modulation methods that enhance transmission capabilities.

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As global populations become increasingly aged, existing elderly care models are proving insufficient. The development and application of nursing robots have shown potential in addressing the challenges of elder care in aging societies. This perspective outlines current state and potential applications of nursing robots in promoting healthy aging.

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Background: Meat is a good source of protein in the human diet, and more than three-quarters of the world's population consumes it. It is the most perishable food item since it has enough nutrients to enable microbial growth. In underdeveloped nations, animals are routinely slaughtered and sold in unsanitary conditions, compromising the bacteriological quality and safety of the meat received from the animals.

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Contrast-enhanced ultrasonography as a method of monitoring focal liver lesions - initial report.

Clin Exp Hepatol

March 2024

Department of Radiology and Diagnostic Imaging, Norbert Barlicki Memorial Teaching Hospital No. 1, Medical University of Lodz, Poland.

Aim Of The Study: Hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) are benign liver tumors. Hepatocellular adenoma has potential for growth, metaplasia and rupture; therefore, it should be monitored long term. In the current guidelines biopsy is not recommended in the standard diagnostic protocol.

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Concentrations of microplastics are both temporally and spatially variable in streamflow. Yet, an overwhelming number of published field studies do not target a range of flow conditions and fail to adequately capture particle transport within the full flow field. Since microplastic flux models rely on the representativeness of available data, current predictions of riverine exports contain substantial error.

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Functionalized 2D multilayered MXene for selective and continuous recovery of rare earth elements from real wastewater matrix.

J Hazard Mater

January 2025

Centre for Water Technology (WATEC) & Department of Biological and Chemical Engineering, Aarhus University, Ole Worms Allé 3, Aarhus 8000, Denmark. Electronic address:

Rare earth elements (REEs) are the "fuel" for high-tech industry, yet their selective recovery from complex waste matrices is challenging. Herein, we designed a 2D multilayered MXene TiCT adsorbent for selective extraction of REEs in a broad pH range. By establishing strong Lewis acid-base interactions, extraction capacities of TiCT to Eu(III) and Ho(III) reached 892.

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colonization and undernutrition in infants in rural eastern Ethiopia - a longitudinal community-based birth cohort study.

Front Public Health

January 2025

Department of Animal Sciences, Global Food Systems Institute, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States.

Background: is associated with environmental enteric dysfunction (EED) and malnutrition in children. infection could be a linchpin between livestock fecal exposure and health outcomes in low-resource smallholder settings.

Methods: We followed a birth cohort of 106 infants in rural smallholder households in eastern Ethiopia up to 13 months of age.

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Previous toxicological research has suggested the potential neurotoxicity of ultrafine particulate matter (UFP, particles ≤0.1 μm in diameter). However, evidence from human beings, particularly regarding the neurodevelopmental impacts of UFP, is still limited.

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Unveiling the Origin of Copper Accumulation in Plasma with Aging.

Environ Health (Wash)

January 2025

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues.

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In May 2021, the M/V ship fire disaster led to the largest maritime spill of resin pellets (nurdles) and burnt plastic (pyroplastic). Field samples collected from beaches in Sri Lanka nearest to the ship comprised nurdles and pieces of pyroplastic. Three years later, the toxicity of the spilled material remains unresolved.

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Abundant epidemiological studies have conclusively demonstrated the effects of short-term ozone (O) exposure on the incidence and mortality of cardiovascular diseases. However, the mechanism of its influence remains unverified. This study aimed to assess the impact of O on metabolomic-based biomarkers in acute myocardial infarction (AMI) patients.

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