Association of dexmedetomidine and intraoperative thermal insulation with postoperative outcomes in colorectal cancer resection.

Objective: To investigate the effects of dexmedetomidine combined with intraoperative thermal insulation on postoperative cognitive function, cellular immune status and inflammatory markers in patients undergoing radical resection for colorectal cancer.

Methods: Fifty patients who underwent radical resection of colorectal cancer in our hospital from March 2020 to September 2021 were selected and divided into observation group (26 cases with dexmedetomidine combined with intraoperative thermal insulation intervention) and control group (24 cases with conventional anesthesia management). The evaluation measures included the mini-mental state scale (MMSE) score, CD4+ T cell, CD8+ T cell ratio and CD4+/CD8+ ratio, the level of inflammatory markers (IL-6, TNF-α, CRP), and the incidence of postoperative complications.

An intelligent quantification system for fetal heart rhythm assessment: A multicenter prospective study.

Background: The motion relationship and time intervals of the pulsed-wave Doppler (PWD) spectrum are essential for diagnosing fetal arrhythmia. However, few technologies currently are available to automatically calculate fetal cardiac time intervals (CTIs).

Objective: The purpose of this study was to develop a fetal heart rhythm intelligent quantification system (HR-IQS) for the automatic extraction of CTIs and establish the normal reference range for fetal CTIs.

Selenium Deficiency Can Promote the Expression of VEGF and Inflammatory Factors in Cartilage Differentiation and Mediates Cartilage Injury.

Selenium plays a crucial role as a micronutrient, primarily exerting its biological functions through selenoproteins. It has been established that selenium deficiency adversely impacts cartilage development, leading to alterations in chondrocyte function. In regions with low selenium intake, endemic osteochondrosis has been documented, characterized by compromised growth plate and articular cartilage formation.

Serological and Molecular Characterization of Hepatitis B Virus Infection in Gastric Cancer.

Hepatitis B virus (HBV) infection has been reported to be associated with gastric cancer (GC). Nonetheless, no study has revealed the role of HBV infection in the survival of patients with GC, and the mutation profiles of HBV-infected patients with GC have never been documented. Here, we performed an updated meta-analysis and found a significantly increased risk of GC in HBV-infected individuals (sOR, 1.

Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.

Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma glucose levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both the pancreas and liver glucokinase, decreases postprandial glucose in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, the efficacy and safety of dorzagliatin as an add-on therapy to metformin were assessed in patients with T2D who had inadequate glycemic control using metformin alone.

[Screening of interacting proteins of SHIP2 in human gastric mucosal epithelium by yeast two-hybrid system].

Objective To screen a standard homogenous cDNA library of human gastric mucosal epithelium with yeast two-hybrid system and find the proteins that interact with Src-homology 2-containing inositol 5-phosphatase 2 (SHIP2). Methods Using the yeast two-hybrid system, P1 (SH2+5-Ptase) and P2 (PRD+SAM) segments of SHIP2 were used as bait proteins to screen the proteins that bind to SHIP2 from the homogenous cDNA library of human gastric mucosal epithelium. The selected interacting proteins of SHIP2 were verified by co-immunoprecipitation assay.

[Investigation of infestation of in stored jujube from Anhui Province].

Objective: To investigate the breeding of in stored jujube from Anhui Province, so as to provide the evidence for preventing the harm of to stored jujube.

Methods: The jujube samples stored for more than 6 months were collected from dried fruit shops and/or Chinese herbal medicine warehouses, which were chosen as survey sites in Anhui Province. The mites were isolated and identified under a microscope.

[Scanning electron microscopic observation on morphology of ].

Objective: To observe the morphological characteristics of live at different stages of life cycle and its ultrastructure.

Methods: The live specimens were isolated from longan pulp, and firstly rinsed with double distilled water under a light microscope to make slide preparation by the conventional manner, and then were made into scanning electron microscope (SEM) specimens. The specimens were observed under SEM for the ultrastructure characteristics at different developmental stages including egg, larva, nymph and adult (male and female) .

[ infestation in stored traditional Chinese medicine ].

Objective: To investigate the breeding of in the storage , so as to provide the evidence for preventing the harm of to traditional Chinese medicine.

Methods: Chinese herbal medicine warehouses were chosen as survey sites according to the breeding habits of mites, and the samples were stored more than 6 months. The mites were isolated and identified under a microscope.

[ found in dust of air-conditioner filters].

Objective: To investigate the pollution status of in the air conditioner-filters of different places in Wuhu City.

Methods: The dust samples were collected from the filters of air-conditioners in dining rooms, shopping malls, hotels and households between June and September, 2013, and was detected in the dust samples.

Results: There were 430 dust samples collected and 98 were positive with the breeding rate of 22.

Carpoglyphus lactis (Carpoglyphidae) infestation in the stored medicinal Fructus Jujubae.

Objective: To investigate the breeding rate and breeding density of Carpoglyphus lactisin stored Fructus Jujubaein Anhui, China in order to provide a scientific basis for prevention of Carpoglyphus lactis (C. lactis)from spoiling the dried fruit of such category.

Methods: By the breeding nature of C.

[A specific immune therapeutic effect of Der p2 T cell epitope vaccine on asthma mice].

Objective: To investigate the specific immune therapeutic effect of the T cell fusion peptide vaccine from group II allergens from (Der p2).

Methods: Thirty mice were randomly divided into three groups, namely a negative control group (a PBS group), positive control group (an asthma group) and protein Der p2 T cell fusion epitope for specific immunotherapy (SIT) group (a Der p2 T group). The extract of house dust mites (HDM) was used to establish the asthmatic models in BALB/c mice, and the PBS group was always used with PBS buffer.

[ found in stored grains].

Objective: To observe and understand the morphology and structure of in order to create a new record of this mite in China.

Methods: The stored grain samples (rice and brown rice) were collected from the storage of local dwellers, and mites breeding in the products were isolated. Then mite samples were prepared and identified as the previous protocols, and the species was classified in accordance with Hughes.

[ and its hypopus found in feed of ].

Objective: To observe the and its hypopus in feed of .

Methods: Feed samples were collected from farms, and and its hypopus were separated from the samples by the vibration sieve method and floating method. The glass specimens were prepared and and its hypopus were observed under an optical microscope.

Construction of the recombinant vaccine based on T-cell epitope encoding Der p1 and evaluation on its specific immunotherapy efficacy.

Specific immunotherapy (SIT) is currently recognized as the only etiological therapy to ameliorate asthmatic symptom. The current study was aimed at evaluating the immune effect of vaccine MAT3T designed on MHCII pathway, which includes T cell fusion peptide encoding Dermatophagoides pteronyssinus class 1 allergen (Der p1). We initially cloned the nucleotide sequences of TAT, IhC and 3 segments of T cell epitope coding for Der p1, and reassembled these sequences in linear manner to form fusion gene named MAT3T, which was applied to immunize the asthmatic models of mice induced by Der p1 allergen for tentative SIT.

Air-conditioner filters enriching dust mites allergen.

We detected the concentration of dust mites allergen (Der f1 & Der p1) in the air of different places before and after the starting of air-conditioners in Wuhu City, Anhui, China, and to discuss the relation between the dust mites allergen in air-conditioner filters and the asthma attack. The dust samples were collected from the air-conditioner filters in dining rooms, shopping malls, hotels and households respectively. Concentrations of dust mites major group allergen 1 (Der f 1, Der p1) were detected with enzyme linked immunosorbent assay (ELISA), and the dust mite immune activities were determined by dot-ELISA.

Single nucleotide polymorphisms of cathepsin S and the risks of asthma attack induced by acaroid mites.

To investigate association between the three single nucleotide polymorphisms (SNPs, rs146456111, rs143154304 and rs147260142) in cathepsin S (Cat S) and the risks of allergic asthma attack induced by the acaroid mites in the Chinese population. A case-control study was performed in 412 cases and 454 volunteers/controls to evaluate the effects of three SNPs in Cat S on the risks of asthma attack. The genotypes were determined using polymerase chain reaction (PCR) and cleaved amplification polymorphism sequence-tagged sites (PCR-RFLP).

Analysis of T-cell epitopes of Der f3 in Dermatophagoides farina.

House dust mites (HDM) are most important indoor allergens for humans. Der f3, one of the potent allergens with allergenicity, is derived from Dermatophagoides farina (D. farinae), and exhibits strong allergenicity that was confirmed in our previous work.

Gohieria fusca (Acari: Astigmata) found in the filter dusts of air conditioners in China.

Objective: Gohieria fusca(Oudemans, 1902) is recognized to breed in wheat flour, rice, corn, feeds, wheat bran and herbal medicines as well as other stored products, and capable of having mild to moderate cross reactivity with allergens of house dust mites, an important source of indoor allergens associated with asthma and other allergic conditions. Air-conditioning systems are indispensable in public and civil buildings, and the screens of the air conditioners are the most places to accumulate dusts. In order to investigate whether Gohieria fusca can breed in the screens of air-conditioners equipped at either public spaces or civil dwellings in Wuhu city, Anhui province, China.

The density and species of mite breeding in stored products in China.

Objective: The aim of our study was to investigate the species and breeding density of acaroid mites in stored products in China.

Methods: We tentatively harvested the samples from the products stored in warehouses, commercial stores and civilian houses, and the products.

Results: The results suggested the mites varied a lot in species regarding their ecological habitus and habitat.

Association of genetic variants in SOHLH1 and SOHLH2 with non-obstructive azoospermia risk in the Chinese population.

Objective: Spermatogenesis and oogenesis specific basic helix-loop-helix 1 (SOHLH1) and spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2) play essential roles for both spermatogenesis and oogenesis. The aim of this study was to evaluate the association of SOHLH1 and SOHLH2 single nucleotide polymorphisms (SNPs) with non-obstructive azoospermia (NOA) in the Chinese population.

Study Design: In this study, we assessed 7 single nucleotide polymorphisms (SNPs) of SOHLH1 and SOHLH2 with Sequenom iplex technology in 361 NOA cases and 368 fertile controls.

Design of a ProDer f 1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy.

Dermatophagoides farinae (Der f 1) is one of leading cause for allergic asthma, and allergen-specific immunotherapy (SIT) is currently recognized as the only etiological therapy to ameliorate asthmatic symptom. The current study was designed on the major histocompatibility complex (MHC) class II pathway, invariant chain (Ii)-segment hybrids as vaccine basis to explore the efficacy of Der f 1 hybrid vaccine by virtue of Ii as carrier in enhancing the protective immune response to asthma. Initially, we engineered a fused molecule, DCP-IhC-ProDer f 1, to deliver ProDer f 1 antigen via specific dendritic cell-targeting peptides to dendritic cells (DCs).

Acaroid mite allergens from the filters of air-conditioning system in China.

Accumulation of acaroid mites in the filters of air-conditioners is harmful to human health. It is important to clarify the allergen components of mites from the filters of local air-conditioning system. The present study was to detect the allergen types in the filters of air-conditioners and assesse their allergenicity by asthmatic models.