Modular access to furo[3,2-]chromen-4-ones Yb(OTf)-catalyzed [3 + 2] annulation of 4-hydroxycoumarins with β-nitroalkenes.

A facile and efficient strategy for modular access to furo[3,2-]chromen-4-ones using 4-hydroxycoumarin and β-nitroalkenes Lewis acid-catalyzed formal [3 + 2] annulation protocol is described. This reaction proceeds cascade Michael addition/nucleophilic addition/elimination in the presence of Yb(OTf), which involves the formation of two new σ (C-C and C-O) bonds for the construction of a novel furan ring in a single operation. This protocol affords a variety of functional groups, thereby providing a practical and efficient method for the fabrication of a furo[3,2-]chromen-4-one framework.

[Combination of shikonin and gefitinib reverses drug resistance in human non-small cell lung cancer and its mechanism].

The occurrence and development of tumors are associated with the cell energy metabolism. Inhibiting energy metabolism of lung cancer cells is an important strategy to overcome drug resistance. Based on the cellular energy metabolism pathway, this study observed the effect of combination of shikonin(SKN) and gefitinib(GFB) on the drug resistance in non-small cell lung cancer and explored the underlying mechanism.

[Molecular mechanism of ligustilide attenuating OGD/R injury in PC12 cells by inhibiting ferroptosis].

The aim of this study is to explore the mechanism of ligustilide, the main active constituent of essential oils of traditional Chinese medicine Angelicae Sinensis Radix, on alleviating oxygen-glucose deprivation/reperfusion(OGD/R) injury in PC12 cells from the perspective of ferroptosis. OGD/R was induced in vitro, and 12 h after ligustilide addition during reperfusion, cell viability was detected by cell counting kit-8(CCK-8) assay. DCFH-DA staining was used to detect the level of intracellular reactive oxygen species(ROS).

[Mechanism of total flavonoids of Rhododendra simsii in alleviating ischemic brain injury].

This study explores the effect of total flavonoids of Rhododendra simsii(TFR) on middle cerebral artery occlusion(MCAO)-induced cerebral injury in rats and oxygen-glucose deprivation/reoxygenation(OGD/R) injury in PC12 cells and the underlying mechanism. The MCAO method was used to induce focal ischemic cerebral injury in rats. Male SD rats were randomized into sham group, model group, and TFR group.

Exploration of active sites of ethyl alcohol electro-oxidation on porous gold nanoparticles with enhanced Raman spectroscopy.

Novel porous gold nanospheres are prepared by calcination of the gold-urea complexes. The enhanced Raman spectra of ethanol catalyzed by different doses of porous gold nanospheres are measured with a 532 nm laser as the excitation source, and an enhanced charge coupled device served in spectral detection and microscopic imaging. The electrochemical experiments show that the catalytic oxidation products of ethanol with porous gold nanoparticles are acetaldehyde, acetic acid, and water, which further proved that the porous gold nanoparticles can activate the -CH of ethanol.

Synthesis of pyrano[3,2-]quinolones and furo[3,2-]quinolones acid-catalyzed tandem reaction of 4-hydroxy-1-methylquinolin-2(1)-one and propargylic alcohols.

Two acid-catalyzed tandem reactions between 4-hydroxy-1-methylquinolin-2(1)-one and propargylic alcohols are described. Depending mainly on the propargylic alcohol used, these tandem reactions proceed either a Friedel-Crafts-type allenylation followed by 6--dig cyclization sequence to form pyrano[3,2-]quinolones or a Friedel-Crafts-type alkylation and 5--dig ring closure sequence to afford furo[3,2-]quinolones in moderate-to-high yields. The pyrano[3,2-]quinolones products could be further transformed to tetracyclic 4,9-dihydro-5-cyclopenta[]phenanthridin-5-one derivatives.

[Protective effect of total flavonoids of Rhododendron simsii on focal cerebral ischemia-reperfusion injury through SOCE pathway in rats].

This paper explored the protective effect of total flavonoids of Rhododendron simsii(TFR) on focal cerebral ischemia-reperfusion injury(CIRI) in rats and its relationship with the store-operated calcium entry(SOCE) pathway regulated by stromal intera-ction molecule(STIM) and calcium release-activated calcium modulator(Orai).Rats were randomly assigned into the sham group, model(middle cerebral artery occlusion, MCAO) group, TFR(60 mg·kg~(-1)) group, TFR(60 mg·kg~(-1))+SOCE pathway inhibitor 2-aminoethoxydiphenyl borate(2-APB, 2.5 mg·kg~(-1)) group, and 2-APB(2.

Surfactant-free synthesis of fluorescent platinum nanoclusters using HEPES buffer for hypochlorous acid sensing and imaging.

A surfactant-free synthesis of noble-metal nanoclusters (NMNCs) with specific function has recently remained more attractive and superior in bio-applications. Herein, by employing the weak reducibility of non-toxic HEPES, we prepared novel water-soluble fluorescent HEPES@Pt NCs by a simple surfactant-free synthesis strategy for hypochlorous acid (HClO) sensing. The as-prepared Pt NCs featured ultra-small size (∼2 nm), bright blue fluorescence, high stability and biocompatibility, and the fluorescence of the Pt NC nanoprobe can be specifically quenched with hypochlorous acid by a static quenching process.

Application of distant live broadcast in clinical anesthesiology teaching.

Objective: To explore the application value and effect of distance live broadcast in Clinical Anesthesiology teaching.

Methods: Undergraduate students of year 2017 who majored in Anesthesiology at the Wannan Medical College (China) were chosen as the study subjects. According to the different teaching methods, the students were divided into two groups: 59 in the traditional teaching group (control group) and 61 in the traditional teaching combined with distant live broadcasting teaching group (observation group).

[Study on anticoagulant material basis and mechanism of Trichosanthis Semen and its shell and kernel based on spectrum-effect relationship integrated molecular docking].

This study explored the anticoagulant material basis and mechanism of Trichosanthis Semen and its shell and kernel based on spectrum-effect relationship-integrated molecular docking. High performance liquid chromatography(HPLC) fingerprints of Trichosanthis Semen and its shell and kernel were established. Prothrombin time(PT) and activated partial thromboplastin time(APTT) in mice in the low-and high-dose(5, 30 g·kg~(-1), respectively) Trichosanthis Semen, the shell, and kernel groups were determined as the coagulation markers.

Association of single nucleotide polymorphisms in gene with risk of hypertension: a systematic review and meta-analysis.

Background: Hypertension has been continuing to be a major contributor to the global burden of disease and to the global mortality, leading to over 10 million deaths each year. The purpose of this study was to investigate the association between Adiponectin gene polymorphism with Essential hypertension (EH).

Methods: PubMed, EMbase, the Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched independently by two investigators.

[Prediction of anti-liver fibrosis effect of Piperis Longi Fructus based on network pharmacology].

Network pharmacology and liver fibrosis(LF) model in vitro were used to analyze the underly mechanism of anti-liver fibrosis effect that induced by Piperis Longi Fructus and its major active compounds. TCMSP and TCMIP were used to search for the chemical constituents of Piperis Longi Fructus, as well as the oral bioavailability(OB), drug-likeness(DL), intercellular permeability of intestinal epithelial cells(Caco-2) and Drug-likeness grading were set as limiting conditions. The related target genes of Piperis Longi Fructus were queried by TCMSP database, while related targets of LF were screened by GeneCards databases.

[Chrysin inhibited epithelial-mesenchymal transition of type Ⅱ alveolar epithelial cell by regulating NF-κB/Twist 1 signaling pathway].

This study aimed to assess whether chrysin(ChR) can inhibit epithelial-mesenchymal transition(EMT) of type Ⅱ alveolar epithelial cell and produce anti-pulmonary fibrosis effect by regulating the NF-κB/Twist 1 signaling pathway. Sixty rats were randomly divided into the control group, the bleomycin(BLC) group, BLC+ChR(50 mg·kg~(-1)) group and BLC+ChR(100 mg·kg~(-1)) group, with 15 rats in each group. The pulmonary fibrosis model was induced by intratracheal injection of BLC(7 500 U·kg~(-1)).

[Research progress on genus Clinopodium].

The plants of genus Clinopodium are perennial herbs of Labiatae, which are widely distributed in the world and have a promising medicinal value. Modern researches have shown flavonoids, triterpenoid saponins, terpene glycosides, terpenoids, volatile oils and phenylpropanoids are the main compounds in the plants, presenting various pharmacological effects such as hemostasis, anti-bacteria, anti-inflammation, immunoregulation, reducing blood glucose, antioxidation, and anti-tumor effects. The preparations made of those plants are mainly used for treatment of various bleeding diseases in clinical application.

Hydrothermal control, characterization, growth mechanism, and photoluminescence properties of highly crystalline 1D Eu(OH) nanostructures.

Six types of 1D Eu(OH) nanostructures with typical morphologies, including short hexagonal prism, long hexagonal prism, coiling rod, short rod, long rod, and nanobunch, were synthesized the hydrothermal route using EuCl and NaOH as raw materials. The morphologies, sizes, structures, and compositions of the as-prepared products were characterized by scanning electron microscopy, transmission electron microscopy, selected area electron diffraction, X-ray diffraction, and Fourier transform infrared spectroscopy. The effects of different reaction conditions on the morphology and size of the products were also investigated, and the relevant growth mechanism was assessed.

Lycopene attenuates LPS-induced liver injury by inactivation of NF-κB/COX-2 signaling.

Aim: This study aimed to investigate the effect of lycopene on LPS-induced liver injury in mice and its mechanisms.

Methods: Male C57bl/6 mice were randomly assigned to three groups: sham control group (S-C), LPS control group (L-C), lycopene treatment group (L-T). The mice from the L-T were treated with lycopene for 2 weeks, and the remaining mice with solvent.

[TLR4/NF-kappaB p65 signaling pathway mediates protective effect of triptolide on endothelium in rats with endotoxemia].

The aim of this paper was to observe the effect of triptolide( TP) on cardiovascular function and its possible mechanism by intraperitoneal injection of bacterial lipopolysaccharide in rats with endotoxemia. Sixty male Sprague-Dawley rats were randomly divided intonormal group( NC group),endotoxemia model group( LPS group),TP low concentration intervention group( LPS + TP-L group,25 μg·kg~(-1)),TP middle concentration intervention group( LPS+TP-M group,50 μg·kg~(-1)),TP high concentration intervention group( LPS+TP-H group,100 μg·kg~(-1)) and polymyxin B group( LPS+PMX-B group,0. 2 mg·kg~(-1)).

Surfactant-free synthesis of porous Au by a urea complex.

We report a facile surfactant-free synthetic method to obtain porous and hollow Au nanoparticles using only urea and HAuCl·4HO as precursors at 200 °C. The formation mechanism was investigated through X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy. Moreover, the prepared Au nanocrystals present superior catalytic performance for the reduction of 4-nitrophenol in comparison with solid Au nanoparticles.

Whole grain and cereal fiber intake and the risk of type 2 diabetes: a meta-analysis.

In recent years, cardiovascular diseases (CVDs) have become a focus topic and global concern. There have been mixed reports on the relationship between whole grain or cereal fiber intake and the risk of type 2 diabetes. To evaluate whole grain or cereal intake on the risk of type 2 diabetes, we collected related literature on the relationship between whole grain or cereal fiber intake and the risk of type 2 diabetes.

Measuring physical performance in university students.

Unlabelled: Physical activity could be an effective way to prevent obesity and cardiovascular disease.

Objective: The aim of our study was to evaluate physical performance in Chinese university students to offer a basis for preventing obesity.

Methods: A cross-sectional study was conducted for evaluate physical performance, including the standing long jump, 50-meter dash, and pull-up/sit-up test.

[Anti-platelet aggregation and anti-thrombotic mechanism of Trichosanthis Fructus combined with aspirin based on network pharmacology].

To explore the anti-platelet aggregation and anti-thrombotic mechanisms of Trichosanthis Fructus combined with aspirin based on network pharmacology and the validation of arteriovenous by pass model in rats. The databases of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),Drug Repositioning and Adverse Drug Reaction Chemical-Protein Interactome(DRAR-CPI),Universal Protein Resource(Uniprot) and the Database for Annotation,Visualization,and Integrated Discovery(DAVID) were used to predict protein targets and analyze biological pathway and signal pathway in the combination of Trichosanthis Fructus with aspirin. The effects of pretreatment with Trichosanthis Fructus pellets,aspirin pellets and their combination on thromboxane B2(TXB2),6-keto prostaglandin F1α(6-keto-PGF1α) and cyclic adenosine monophosphate(c AMP) in rat thrombotic model were studied.

Immunomodulatory activity of a fructooligosaccharide isolated from burdock roots.

A novel burdock fructooligosaccharide (BFO-1) was extracted from fresh burdock roots. In our study, we found that BFO-1 possessed immunoenhancing activity and . The proliferation activities of splenocytes were significantly stimulated at a BFO-1 dose of 1000 μg ml ( < 0.