Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non-Severe Ventriculomegaly.

Purpose: The impact of ventriculomegaly (VM) on cortical development and brain functionality has been extensively explored in existing literature. VM has been associated with higher risks of attention-deficit and hyperactivity disorders, as well as cognitive, language, and behavior deficits. Some studies have also shown a relationship between VM and cortical overgrowth, along with reduced cortical folding, both in fetuses and neonates.

Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study.

Background: There is scarce literature evaluating long term psychological or Quality of Life (QoL) outcomes in family members of ICU survivors, who have not experienced invasive ventilation. The objective was to compare long-term psychological symptoms and QoL outcomes in family members of intubated versus non-intubated ICU survivors and to evaluate dyadic relationships between paired family members and survivors.

Methods: Prospective, multicentre cohort study among four medical-surgical ICUs in Australia.

Irritability as a Transdiagnostic Construct Across Childhood and Adolescence: A Systematic Review and Meta-analysis.

This meta-analytic review examined irritability across childhood and adolescence as it relates to symptoms of common mental health disorders in these periods. Of key interest was whether the relationship between irritability and symptom severity varies according to symptom domain. This was tested at the level of broad symptom dimensions (internalizing versus externalizing problems) as well as discrete diagnostic domains (e.

Providing appropriate health and social care for people with dementia or mild cognitive impairment in the criminal justice system of England and Wales: a thematic analysis of prisoner and staff interview data.

Background: The number of older adults entering the criminal justice system is growing. Approximately 8% of older prisoners in England and Wales have suspected dementia or mild cognitive impairment (MCI) and experience difficulties in everyday functioning, and disruption to their daily life. At present, no specific dementia/MCI care pathway has been implemented that is applicable and appropriate for use across different prisons in England and Wales.

Fetal Corpus Callosum Anomalies: A Review of Underlying Genetic Disorders and Prenatal Testing Options.

Anomalies of the corpus callosum (CC) are amongst the most common fetal Central Nervous System (CNS) anomalies detectable on ultrasound. Underlying genetic disease plays an important part in defining prognosis. Associations with aneuploidy and submicroscopic chromosomal deletions or duplications have been well demonstrated using chromosomal microarray analysis.

Outcomes of a fledgling public dermatology clinic in rural Australia.

There is paucity of research available regarding the epidemiological characteristics of patients attending dermatology outpatient services in rural Australia. We performed a retrospective cohort study of patients attending a public dermatology clinic established at Dubbo Base Hospital in rural New South Wales. The broad range of dermatological presentations encountered, coupled with the brisk uptake of services by remote patients, highlights the ongoing need for specialist dermatology services in underserved rural communities.

Nurse-Led/Involved Home-Based Interventions for Older Adults With Chronic Obstructive Pulmonary Disease (COPD): A Mixed-Methods Systematic Review.

Aims: To determine the effectiveness of nurse-led/involved home-based interventions for older people with COPD and to explore the experiences of older people and nurses with the interventions.

Design: A mixed-methods systematic review following the JBI methodology for mixed-methods systematic reviews.

Data Sources: The search included relevant and peer-reviewed studies published from January 2010 to December 2023 in CINAHL, MEDLINE, Cochrane Central Register of Controlled Trials, PsycINFO, EMBASE, JBI, EMCARE and ProQuest.

Models of Care for Older People: A Scoping Review.

Background: International recognition of the increasing importance of care for older people has seen growing interest in models of care for older people. Yet there is limited information about the scope and breadth of models of care for older people. This article clarifies what is known about models of care for older people by summarizing relevant publications, describing the models depicted in these publications, and synthesizing the outcomes and impact presented in the publications.

Nanofiltration Membranes for Efficient Lithium Extraction from Salt-Lake Brine: A Critical Review.

The global transition to clean energy technologies has escalated the demand for lithium (Li), a critical component in rechargeable Li-ion batteries, highlighting the urgent need for efficient and sustainable Li extraction methods. Nanofiltration (NF)-based separations have emerged as a promising solution, offering selective separation capabilities that could advance resource extraction and recovery. However, an NF-based lithium extraction process differs significantly from conventional water treatment, necessitating a paradigm shift in membrane materials design, performance evaluation metrics, and process optimization.

Spatio-Temporal Changes in Effective Population Size in an Expanding Metapopulation of Eurasian Otters.

Conservation efforts are leading to demographic growth and spatial expansion of some previously endangered species. However, past population bottlenecks or population size fluctuations can have lasting effects on effective population size ( ), even when census size ( ) appears large or recovered. The UK metapopulation of Eurasian otters () has a well-documented history of population recovery over recent decades, with indicators of presence (faeces and footprints) increasing in distribution and number over successive national surveys.

The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.

Antibody-drug conjugates (ADCs) combining monoclonal antibodies with cytotoxic payloads are a rapidly emerging class of immune-based therapeutics with the potential to improve the treatment of cancer, including children with relapse/refractory acute lymphoblastic leukemia (ALL). CD123, the α subunit of the interleukin-3 receptor, is overexpressed in ALL and is a potential therapeutic target. Here, we show that pivekimab sunirine (PVEK), a recently developed ADC comprising the CD123-targeting antibody, G4723A, and the cytotoxic payload, DGN549, was highly effective in vivo against a large panel of pediatric ALL patient-derived xenograft (PDX) models ( = 39).

Analysis of the determinants of alcohol consumption and expenditure in Ecuador: an econometric analysis.

Background: This study delves into the determinants of alcohol consumption and expenditure in Ecuador, focusing on personal characteristics, education levels, and regional variations. This study aimed to provide nuanced insights into alcohol-related behaviors within the Ecuadorian population.

Methods: Employing probit and Tobit models, the study ensures a robust analytical framework to assess the factors influencing alcohol consumption and expenditure.

Using primary and routinely collected data to determine prevalence and patterns of multimorbidity in rural China: a representative cross-sectional study of 6474 Chinese adults.

Background: In China, rising chronic diseases has coincided with the increasing burden of multimorbidity, particularly for vulnerable populations. Limited primary data are available to understand the prevalence and patterns of multimorbidity, especially in resource-limited rural areas. This study aims to conduct robust evaluations of the prevalence and patterns of multimorbidity among rural adults in China, and to compare the differences in prevalence and patterns when using primary data alone versus in combination with routinely collected data.

Overview of multimorbidity research in India: a scoping review protocol.

Background: Due to demographic and epidemiological shifts, people are living until older ages with more morbidities. These morbidities often have shared pathophysiology, which leads to a rise in coexisting health issues known as 'multimorbidity'. Primary care studies and disease burden surveys have multiplied, unveiling varied aspects of multimorbidity, yet with inconsistent definitions and methods.

Systemic Circulation in Advanced Heart Failure and Cardiogenic Shock: State-of-the-Art Review.

The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle. The net effect is increased myocardial oxygen demand and reduced coronary perfusion pressure, thereby further deteriorating contractile function.

Fluoxetine and fractures after stroke: an individual patient data meta-analysis of three large randomised controlled trials of fluoxetine for stroke recovery.

Background: Observational studies have shown that selective serotonin reuptake inhibitors are associated with an increased risk of bone fractures, but the association can be confounded by indication and other sources of systematic bias that can be minimised in randomised controlled trials (RCTs).

Aim: Our aim was to report the rate, site, context, and predictors of fractures after stroke, and whether the fractures modified the effect of fluoxetine on modified Rankin score (mRS) at six months in an individual patient data meta-analysis of 5907 patients enrolled in three RCTs of fluoxetine (20mg for six months) for stroke recovery.

Methods: We classified fractures by treatment allocation, site (and thus likelihood of osteoporosis) and context, then performed multivariable analyses to explore independent predictors of fractures.

Methods for data extraction and data transformation in convergent integrated mixed methods systematic reviews.

Objective: The objective of this guidance paper is to describe data transformation involving qualitization, including when and how to undertake this process, and to clarify how it aligns with data extraction in order to expand on the current guidance for JBI convergent integrated mixed methods systematic reviews (MMSRs).

Introduction: The convergent integrated approach to MMSRs involves combining extracted data from both quantitative studies (including the quantitative components of mixed methods studies) and qualitative studies (including the qualitative components of mixed methods studies). This process requires data transformation, which can occur either by converting qualitative data into quantitative data (ie, quantitizing) or converting quantitative data into qualitative data (ie, qualitizing).

Missing data in the eligibility criteria of synthetic controls from real-world data.

Randomized clinical trials (RCTs) can benefit from using Real-World Data (RWD) as a supplementary data source to enhance their analysis. An Augmented RCT combines randomized treatment and control groups with synthetic controls derived from RWD. This way, the trial can achieve less prospective enrollment, higher statistical power, and lower costs.

Patients' Perceptions of the Efficacy, Safety, and Quality of the Evidence of Medicinal Cannabis: A Survey of Australian Cancer Patients.

Introduction: Despite the increased demand for medical cannabis (MC), MASCC guidelines state that there is insufficient evidence of its efficacy and safety. Although research has explored medical professionals' perceptions of MC, there is to our knowledge minimal research exploring patients' perceptions, particularly in an Australian cancer setting.

Methods: A survey of Australian cancer patients attending oncology outpatient clinics was performed.

Detoxome Capacity of the Adult Rumen Fluke Extends into Its Secreted Extracellular Vesicles.

Helminth parasites have long adapted to survive hostile host environments and can likely adapt against the chemical anthelmintic challenge. One proposed adaptation route is via Phase I and II xenobiotic metabolizing enzymes (XMEs). For successful Helminth pharmacotherapy discovery programs, a working understanding of Helminth-derived chemical detoxification, the Helminth detoxome, is a must.

Potential role of formononetin as a novel natural agent in Alzheimer's disease and osteoporosis comorbidity.

Background: The growing aging population has led to an increase in the prevalence of Alzheimer's disease (AD) and osteoporosis (OP), both of which significantly impair quality of life. The comorbid nature of these conditions suggests a shared genetic etiology, the understanding of which is crucial for developing targeted therapies.

Objective: This study aims to explore the shared genetic etiology underlying AD and OP, using a system biology approach to identify potential therapeutic targets and natural compounds for treatment.

Persistent Eosinophilic Inflammation Is Not a Feature of Type 2 CRS Patients Failing Anti-IL-5R Therapy and Requiring Class Switching to Anti-IL-4/13.

Background: Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL-4, -5, and -13 are prominent disease mediators. Disease control can be achieved with biologic therapies.