24,691 results match your criteria: "Wake-Forest University[Affiliation]"
Life Sci Space Res (Amst)
February 2025
Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Future long duration space missions will expose astronauts to higher doses of galactic cosmic radiation (GCR) than those experienced on the international space station. Recent studies have demonstrated astronauts may be at risk for cardiovascular complications due to increased radiation exposure and fluid shift from microgravity. However, there is a lack of direct evidence on how the cardiovascular system is affected by GCR and microgravity since no astronauts have been exposed to exploratory mission relevant GCR doses.
View Article and Find Full Text PDFLife Sci Space Res (Amst)
February 2025
Department of Biomedical Engineering, Center for Injury Biomechanics, Wake Forest University School of Medicine. 575 N. Patterson Avenue, Suite 530. Winston-Salem, NC 27101, USA. Electronic address:
Muscle atrophy occurs with extended exposure to microgravity. This study quantified the overall muscle size, lean muscle area and fat infiltration changes pre- to post-flight that occur in the thoracic and lumbar spine with long-duration spaceflight. Pre- and post-flight magnetic resonance imaging (MRI) scans were obtained from 9 crewmembers on long-duration (≥6 months) International Space Station (ISS) missions.
View Article and Find Full Text PDFNutrients
January 2025
Division of Clinical Nutrition, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA.
The aim of this study was to examine the adherence, changes in weight, and, waist circumference associated with the daily consumption of a culturally preferred food, namely an avocado, among Hispanic/Latina females in the Habitual Diet and Avocado Trial (HAT). HAT was a multisite, randomized controlled trial conducted between 2018 and 2020. Participants in the Avocado-Supplemented Diet Group were provided with and instructed to consume one avocado/day (~2.
View Article and Find Full Text PDFJ Clin Med
January 2025
Precision Medicine Unit, Department of Gastroenterology, São João University Hospital, Alameda Professor Hernâni Monteiro, 4200-427 Porto, Portugal.
Several artificial intelligence systems based on large language models (LLMs) have been commercially developed, with recent interest in integrating them for clinical questions. Recent versions now include image analysis capacity, but their performance in gastroenterology remains untested. This study assesses ChatGPT-4's performance in interpreting gastroenterology images.
View Article and Find Full Text PDFEpidemiology
January 2025
Department of Statistical Sciences, College of Arts and Sciences, Wake Forest University, Winston-Salem, North Carolina.
Background: The overdose epidemic remains largely driven by opioids, but county-level prevalence of opioid misuse is unknown. Without this information, public health and policy responses are limited by a lack of knowledge on the scope of the problem.
Methods: Using an integrated abundance model, we estimate annual county-level prevalence of opioid misuse for counties in North Carolina from 2016 to 2021.
J Med Internet Res
January 2025
Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, US.
Background: Most cancer survivors have multiple cardiovascular risk factors, increasing their risk of poor cardiovascular and cancer outcomes. The Automated Heart-Health Assessment (AH-HA) tool is a novel electronic health record clinical decision support tool based on the American Heart Association's Life's Simple 7 cardiovascular health (CVH) metrics to promote CVH assessment and discussion in outpatient oncology. Before proceeding to future implementation trials, it is critical to establish the acceptability of the tool among providers and survivors.
View Article and Find Full Text PDFStat Med
February 2025
Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada.
Brain imaging data is one of the primary predictors for assessing the risk of Alzheimer's disease (AD). This study aims to extract image-based features associated with the possibly right-censored time-to-event outcomes and to improve predictive performance. While the functional proportional hazards model is well-studied in the literature, these studies often do not consider the existence of patients who have a very low risk and are approximately insusceptible to AD.
View Article and Find Full Text PDFAm J Dermatopathol
February 2025
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC; and.
Am J Dermatopathol
February 2025
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC; and.
Am J Dermatopathol
February 2025
Departments of Dermatology and Pathology, School of Medicine, Wake Forest University, Medical Center BLVD, Winston Salem, NC.
Primary vulvar carcinomas are rare and constitute a diverse group of neoplasms. These primary tumors are typically classified based on their presumed tissue of origin or histological characteristics. Among these, carcinomas of sweat gland origin are particularly significant.
View Article and Find Full Text PDFCells
January 2025
Department of Biochemistry, School of Medicine, Wake Forest University, Winston Salem, NC 27101, USA.
Glucose-sensing ChREBP and MondoA are transcriptional factors involved in the lipogenic, inflammatory, and insulin signaling pathways implicated in metabolic disorders; however, limited ocular studies have been conducted on these proteins. We aimed to investigate the potential role of ChREBP in the pathogenesis of diabetic retinopathy (DR). We used diabetic human and mouse retinal cryosections analyzed by immunohistochemistry.
View Article and Find Full Text PDFBrain Sci
January 2025
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Charcot first described ALS in 1869, but the specific mechanisms that mediate the disease pathology are still not clear. Intense research efforts have provided insight into unique neuroanatomical regions, specific neuronal populations and genetic associations for ALS and other neurodegenerative diseases; however, the experimental results also suggest a convergence of these events to common toxic pathways. We propose that common toxic pathways can be therapeutically targeted, and this intervention will be effective in slowing progression and improving patient quality of life.
View Article and Find Full Text PDFBioengineering (Basel)
January 2025
Center for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
In a prospective study, we examined the recovery trajectory of patients with lower extremity fractures to better understand the healing process in the absence of complications. Using a chest-mounted inertial measurement unit (IMU) device for gait analysis and collecting patient-reported outcome measures, we focused on 12 key gait variables, including Mean Leg Lift Acceleration, Stance Time, and Body Orientation. We employed a linear mixed model (LMM) to analyze these variables over time, incorporating both fixed and random effects to account for individual differences and the time since injury.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, United States of America.
Background: Latine populations in the United States continue to be disproportionately affected by COVID-19 with high rates of infection and mortality. Our community-based participatory research partnership examined factors associated with COVID-19 testing and vaccination within a particularly hidden, underserved, and vulnerable population: Spanish-speaking Latines.
Methods: In 2023, native Spanish-speaking Latine interviewers conducted phone-based structured individual assessments with 180 Spanish-speaking, predominantly immigrant Latines across North Carolina.
JACC Cardiovasc Interv
January 2025
Sanger Heart & Vascular Institute, Charlotte, North Carolina, USA.
JAAPA
February 2025
Elizabeth C. Pinyan is a junior research associate in the UNC Highway Safety Research Center in Chapel Hill, N.C. She previously served as the program assistant for the Center for Advanced Practice at Atrium Health Wake Forest Baptist. Elizabeth Tysinger is an NP and educator in internal medicine in the Multi-Specialty Infusion Clinic at Atrium Health Wake Forest Baptist in Winston-Salem, N.C. Rachel Zimmer is an assistant professor in the Department of Implementation Science, Division of Public Health Sciences at Atrium Health Wake Forest Baptist. Kathleen Wetherell Griffin is a pediatric neurology NP at Atrium Health Wake Forest Baptist. Eileen Ronsheim is an orthopedic NP at Atrium Health Wake Forest Baptist. Andrea McKinnond is an assistant professor and director of clinical education in the PA program at Wake Forest University in Winston-Salem, N.C., and practices in the Department of Otolaryngology/Head and Neck Cancer at Atrium Health Wake Forest Baptist in Winston-Salem, N.C. Chisom Okoye is program coordinator of the Center for Advanced Practice at Atrium Health Wake Forest Baptist. Alisha T. DeTroye is regional director of advanced practice at Atrium Health Wake Forest Baptist and practices in hematology and oncology at Atrium Health Wake Forest Baptist. The authors have disclosed no potential conflicts of interest, financial or otherwise.
This article describes a framework for the development, implementation, and effect of advanced practice provider (APP) grand rounds. A team of certified registered nurse anesthetists (CRNAs), NPs, and physician associates/assistants (PAs) developed and operationalized a grand rounds initiative in 2019. Since January 2020, 34 live monthly learning sessions have been held in person and virtually.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston Salem, NC, USA.
Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
January 2025
Division of Cardiovascular & Thoracic Anesthesia, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA.
Obesity (Silver Spring)
February 2025
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Objective: We assessed the impact of a food-provisioning intervention on diet quality in children with obesity.
Methods: Participants (n = 33, aged 6-11 years) were randomly assigned to either usual care (intensive health behavior and lifestyle treatment) or intervention (usual care + food provisioning; high-fiber, low-dairy diet) for 4 weeks. The primary outcome was a change in child diet quality at Week 4.
J Am Acad Dermatol
January 2025
Callender Dermatology & Cosmetic Center, Glenn Dale, MD, USA; Department of Dermatology, Howard University College of Medicine, Washington, D.C., USA.
Am J Surg
January 2025
Department of Surgery, Division of Trauma and Acute Care Surgery, Atrium Health Wake Forest Baptist Hospital, Winston-Salem, NC, United States.
Introduction: We sought to construct a simple clinical mortality prediction model in trauma patients that required pre-injury hemodialysis: Hemodialysis Outcomes Score in Trauma (HOST).
Methods: Trauma patients on pre-injury hemodialysis admitted between July 2013 to December 2021 were reviewed. Univariate and multivariable analysis was used to determine independent predictors of mortality and construct the HOST score.
Vaccine
January 2025
Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: Substantial investments by government programs and private health plans subsidized the costs of COVID-19 vaccine doses and vaccine administration. The objective of this study was to evaluate the cost-effectiveness of vaccination against COVID-19 illness during the initial year of COVID-19 vaccination (2021).
Methods: Using a simulation model, we projected outcomes for hypothetical cohorts of US adults aged 18 and older, stratified by age and risk status for complications, comparing vaccination and no vaccination in the context of recommended concomitant prevention strategies (e.
PLoS One
January 2025
Female Brain & Endocrine Health Research (FemBER) Consortium.
Background: Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.
View Article and Find Full Text PDFJAMA Cardiol
January 2025
Department of Medicine, Division of General Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Importance: Nocturnal hypertension while asleep is associated with substantial increases in risk of cardiovascular disease (CVD) and death. Whether hypertension while supine is a risk factor associated with CVD independent of seated hypertension remains unknown.
Objective: To investigate the association between supine hypertension and CVD outcomes and by hypertension treatment status.
Radiat Environ Biophys
January 2025
Department of Environmental Health Sciences, #820-11, Slot, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham Str, Little Rock, AR, 72205, USA.
Most studies on the effects of galactic cosmic rays (GCR) have relied on terrestrial irradiation using spatially homogeneous dose distributions of mono-energetic beams comprised of one ion species. Here, we exposed mice to novel beams that more closely mimic GCR, namely, comprising poly-energetic ions of multiple species. Six-month-old male and female C57BL/6J mice were exposed to 0 Gy, 0.
View Article and Find Full Text PDF