BJA Open
March 2022
Outcomes Research Consortium, Cleveland, OH, USA.
Background: Several continuous monitoring solutions, including wireless wearable sensors, are available or being developed to improve patient surveillance on surgical wards. We designed a survey to understand the current perception and expectations of anaesthesiologists who, as perioperative physicians, are increasingly involved in postoperative care.
Methods: The survey was shared in 40 university hospitals from Western Europe and the USA.
Blood Cancer J
February 2022
Duke University Medical Center, Durham, NC, 27710, USA.
J Orthop Trauma
October 2021
Division of Orthopaedic Trauma and Adult Reconstruction, Department of Orthopaedic Surgery, Jersey City Medical Center/Saint Barnabas Medical Center-RWJBarnabas Health, Jersey City, NJ.
Distal femur fractures in the elderly have been historically treated with locked plating or retrograde intramedullary nailing with good, reliable results. However, in certain more complex fracture patterns (native or periprosthetic), increased density of fixation via dual-plate or nail plate combination can help achieve immediate weight-bearing. It can also potentially increase rates of union by shifting and maintaining the neutral axis, distributing forces more evenly across the fracture site.
View Article and Find Full Text PDFOrthop J Sports Med
December 2020
Department of Orthopaedic Surgery, Loma Linda University Medical Center, Loma Linda, California, USA.
Background: Citation counts have often been used as a surrogate for the scholarly impact of a particular study, but they do not necessarily correlate with higher-quality investigations. In recent decades, much of the literature regarding shoulder instability is focused on surgical techniques to correct bone loss and prevent recurrence.
Purpose: To determine (1) the top 50 most cited articles in shoulder instability and (2) if there is a correlation between the number of citations and level of evidence or methodological quality.
Injury
December 2021
Department of Orthopaedic Surgery, Wake Forest University Medical Center, Winston Salem, NC, USA. Electronic address:
Background: Radiographic loosening is frequently seen around the radial head (RH) implant. The hypothesis of this study was that radiographic loosening will be more frequent in patients in which the RH prosthesis was implanted due to elbow trauma leading to instability that required lateral collateral ligament repair (LCL).
Materials And Methods: A retrospective review of the patients who had RH implantation between 2012 and 2019 was performed.
Pediatr Rev
January 2021
Department of Urology, Wake Forest University Medical Center, Winston-Salem, NC.
JAMA Cardiol
February 2021
Department of Medicine, University of Mississippi Medical Center, Jackson.
Importance: Up to 20% of patients who present to the emergency department (ED) with acute heart failure (AHF) are discharged without hospitalization. Compared with rates in hospitalized patients, readmission and mortality are worse for ED patients.
Objective: To assess the impact of a self-care intervention on 90-day outcomes in patients with AHF who are discharged from the ED.
J Mol Cell Biol
April 2021
School of Medicine, Nankai University, Tianjin 300071, China.
Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients.
View Article and Find Full Text PDFChest
October 2020
Theravance Biopharma US, Inc., South San Francisco, CA. Electronic address:
Background: Peak inspiratory flow (PIF) has been proposed as a measure to assess a patient's ability to use dry powder inhalers (DPIs). However, robust quality criteria to determine a repeatability limit for measuring PIF are lacking.
Research Questions: What are the repeatability limits for measuring PIF? What is the relationship between PIF measured using the In-Check DIAL device at Diskus (GlaxoSmithKline; PIF) and HandiHaler (Boehringer Ingelheim; PIF) resistances?
Study Design And Methods: Data from a randomized, controlled, phase 3 trial (study 0149; see Clinical Trial Registration data) were used to define repeatability limits for PIF.
Chronic Obstr Pulm Dis
October 2019
Theravance Biopharma US, Inc., South San Francisco, California.
Background: Patients with chronic obstructive pulmonary disease (COPD) and suboptimal peak inspiratory flow rate (sPIFR) may not benefit optimally from dry powder inhalers (DPI) because of inadequate inspiratory flow. Nebulized bronchodilators may provide a better alternative. We compared bronchodilation with the long-acting muscarinic antagonist (LAMA) revefenacin for nebulization versus the DPI LAMA tiotropium, in patients with COPD and sPIFR (< 60 L/min against the resistance of Diskus®).
View Article and Find Full Text PDFBlood
October 2019
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further define the role of rIFN-α, we investigated the outcomes of pegylated-rIFN-α2a (PEG) therapy in ET and PV patients previously treated with hydroxyurea (HU). The Myeloproliferative Disorders Research Consortium (MPD-RC)-111 study was an investigator-initiated, international, multicenter, phase 2 trial evaluating the ability of PEG therapy to induce complete (CR) and partial (PR) hematologic responses in patients with high-risk ET or PV who were either refractory or intolerant to HU.
View Article and Find Full Text PDFLeukemia
December 2019
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clin Exp Gastroenterol Hepatol
March 2019
The Liver-Biliary-Pancreatic Center, Carolinas Medical Center, Charlotte, NC, USA.
We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive at the time of sample collection enrolled in this study. By multivariate analysis, CLDN RNA was found as the single independent factor positively correlated with HCV RNA levels (p=0.
View Article and Find Full Text PDFBackground South Asians have a relatively high prevalence of coronary artery calcium ( CAC ) compared with other race/ethnic groups. We determined CAC incidence and progression among South Asians, and compared them with 4 race/ethnic groups. Methods and Results Data from the MASALA (Mediators of Atherosclerosis in South Asians Living in America) study were used to calculate CAC incidence and progression rates and any CAC change.
View Article and Find Full Text PDFClin Transl Gastroenterol
October 2018
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Background: Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women.
Methods: We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses' Health Study among 51,708 women who were free of FI in 2008.
Surg Oncol Clin N Am
July 2018
Surgical Oncology Service, Department of General Surgery, Wake Forest University, Wake Forest University Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:
Gastroenterology
September 2018
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts.
Background & Aims: Fiber supplements are frequently used as treatment for fecal incontinence (FI), but little is known about the role of dietary fiber in the prevention of FI.
Methods: We performed a prospective study to examine the association between long-term dietary fiber intake and risk of FI in 58,330 older women (mean age, 73 years) in the Nurses' Health Study who were free of FI in 2008. Energy-adjusted long-term dietary fiber intake was determined using food frequency questionnaires starting in 1984 and updated through 2006.
Cancer Lett
May 2018
Dept. of Immunology, Institute of Basic Medical Science, Chinese Academy of Medical Science, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China; Collaborative Innovation Center for Biotherapy, School of Basic Medical Science, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100005, China. Electronic address:
In this study, we present a medium throughput siRNA screen platform to identify inflammation genes that regulate cancer cell stemness. We identified several novel candidates that decrease OCT4 expression and reduce the ALDH + subpopulation both of which are characteristic of stemness. Furthermore, one of the novel candidates ICAM3 up-regulates in the ALDH + subpopulation, the side population and the developed spheres.
View Article and Find Full Text PDFAm J Kidney Dis
December 2017
Division of Nephrology and Hypertension, Department of Medicine, Loyola University Chicago, Maywood, IL; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL.
Stroke risk may be more than 3-fold higher among patients with chronic kidney disease stage 5D (CKD-5D) compared to the general population, with the highest stroke rates noted among those 85 years and older. Atrial fibrillation (AF), a strong risk factor for stroke, is the most common arrhythmia and affects >7% of the population with CKD-5D. Warfarin use is widely acknowledged as an important intervention for stroke prevention with nonvalvular AF in the general population.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
January 2018
Medical University of South Carolina, Charleston, SC, USA.
Introduction: Left atrial appendage (LAA) closure with the WATCHMAN device, according to FDA labelling, is recommended in patients with a maximal LAA ostial width between 17 and 31 mm. The safety and efficacy of LAA closure in patients with a maximal LAA ostial width < 17 mm has not been evaluated. The goal of this study was to determine the acute and short-term safety and efficacy of LAA closure with the WATCHMAN device in patients with a maximal LAA ostial width < 17 mm.
View Article and Find Full Text PDFJ Child Sex Abus
April 2018
i Columbia University Medical Center, New York, New York, USA.
Oncotarget
April 2017
Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Cancer stem cells (CSCs) are recognized as the major source for cancer initiation and recurrence. Yet, the mechanism by which the cancer stem cell properties are acquired and maintained in a cancer cell population is not well understood. In the current study, we observed that the level of active p38 MAPK is downregulated, while the level of the stemness marker SOX2 is upregulated in lung cancer tissues as compared to normal tissues.
View Article and Find Full Text PDFGastroenterology
June 2017
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts.
Background & Aims: Low estrogen levels can contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI.
Methods: We studied the association between MHT and risk of FI among 55,828 postmenopausal women (mean age, 73 years) who participated in the Nurses' Health Study, were enrolled since 2008, and with no report of FI.
J Nucl Med
May 2017
Department of Radiology, Wake Forest University Medical Center, Winston Salem, North Carolina
We report the synthesis and preclinical evaluation of a C-labeled probe to target melanoma using PET. The target compound 4-C-methoxy -(2-diethylaminoethyl) benzamide (4-C-MBZA) was prepared via the C-methylation of 4-hydroxy -(2-diethylaminoethyl) benzamide (4-HBZA). The in vitro binding was performed using B16F1 (melanoma cells), MCF-10A (breast epithelial cells), and MDA-MB 231 (breast cancer cells).
View Article and Find Full Text PDFJ Am Heart Assoc
November 2016
University of California San Francisco, San Francisco, CA
Background: South Asians have a low body mass index and high prevalence of cardiovascular disease (CVD) relative to other racial/ethnic groups. Radiographically detected ectopic fat distribution is better associated with CVD than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence/severity of coronary artery calcium (CAC), a predictor of incident CVD events, among South Asians compared with other racial/ethnic groups.
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