30,547 results match your criteria: "Wageningen University & Research P.O. Box 47 6700 AA Wageningen The Netherlands bart.koelmans@wur.nl.[Affiliation]"

Xylindein is a blue-green pigment produced by the fungi and Its stunning color and optoelectronic properties make xylindein valuable for textiles and as a natural semiconductor material. However, producing xylindein from culture broths remains challenging because of the slow growth of the species and the poor solubility of xylindein in organic solvents. An alternative production route for obtaining pure xylindein is heterologous expression of the xylindein biosynthetic genes.

View Article and Find Full Text PDF

Unraveling the numerous factors that drive phenotypic variation in trait expression among animals has long presented a significant challenge. Whereas traits like growth and adult size are often heritable and are passed on from one generation to the next, these can be significantly affected by the quality and quantity of resources provided by one or both parents to their offspring. In many vertebrates, such as birds and mammals, parents raise their young until adult, providing food, shelter, and protection.

View Article and Find Full Text PDF

The emergence of new viruses and the spread of existing pathogens necessitate efficient vaccine production methods. The baculovirus expression vector system (BEVS) is an efficient and scalable system for subunit and virus-like particle vaccine production and gene therapy vectors. However, current production processes are often limited to low cell concentrations (1-4 × 10 cells/mL) in fed-batch mode.

View Article and Find Full Text PDF

Validation framework for digital measures.

Front Toxicol

January 2025

Digital In Vivo Alliance (DIVA), Redwood City, CA, United States.

The adoption of digital measures in pharmaceutical research and development (R&D) presents an opportunity to enhance the efficiency and effectiveness of discovering and developing new therapeutics. For clinical measures, the Digital Medicine Society's (DiMe) V3 Framework is a comprehensive validation framework that encompasses verification, analytical validation, and clinical validation. This manuscript describes collaborative efforts to adapt this framework to ensure the reliability and relevance of digital measures for a preclinical context.

View Article and Find Full Text PDF

Millions of people are annually infected by mosquito-transmitted arboviruses including dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV) and chikungunya virus (CHIKV). Insect-specific flaviviruses (ISFs), which only infect mosquitoes and cannot replicate in vertebrates, can offers a potential one health strategy to block the transmission of arboviruses by reducing the mosquito's susceptibility for subsequent arbovirus infections through superinfection exclusion (SIE),. Most SIE studies focus on acute ISF infections in RNAi-deficient C6/36 cells.

View Article and Find Full Text PDF

Background: HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a nucleotide-binding leucine-rich repeat (NLR) protein functioning as a recognition hub to initiate effector-triggered immunity against bacterial pathogens. To initiate defense, ZAR1 associates with different HOPZ-ETI-DEFICIENT 1 (ZED1)-Related Kinases (ZRKs) to form resistosomes to indirectly perceive effector-induced perturbations. Few studies have focused on the phylogenomic characteristics of ZAR1 and ZRK immune gene families and their evolutionary relationships.

View Article and Find Full Text PDF

Concentrations of microplastics are both temporally and spatially variable in streamflow. Yet, an overwhelming number of published field studies do not target a range of flow conditions and fail to adequately capture particle transport within the full flow field. Since microplastic flux models rely on the representativeness of available data, current predictions of riverine exports contain substantial error.

View Article and Find Full Text PDF

Bovine milk contains four types of caseins with β-casein being one of the most abundant. Previous studies on cow milk have reported seemingly contradictory effects of β-casein on milk renneting behavior. The aim of this study was to gain a better understanding of how β-casein affects the properties and renneting behavior of casein micelles by using a model system of reassembled casein micelles (RCMs).

View Article and Find Full Text PDF

Grasslands cover approximately a third of the Earth's land surface and account for about a third of terrestrial carbon storage. Yet, we lack strong predictive models of grassland plant biomass, the primary source of carbon in grasslands. This lack of predictive ability may arise from the assumption of linear relationships between plant biomass and the environment and an underestimation of interactions of environmental variables.

View Article and Find Full Text PDF

The concept of animal welfare is evolving due to progress in our scientific understanding of animal biology and changing societal expectations. Animal welfare science has been primarily concerned with minimizing suffering, but there is growing interest in also promoting positive experiences, grouped under the term positive animal welfare (PAW). However, there are discrepancies in the use of the term PAW.

View Article and Find Full Text PDF

Dealing with infections is a daily challenge for wild animals. Empirical data show an increase in reactive oxygen species (ROS) production during immune response. This could have consequences on telomere length, the end parts of linear chromosomes, commonly used as proxy for good health and ageing.

View Article and Find Full Text PDF

Plant-based dietary patterns, nutrient intake, growth, and body composition in childhood: Results from a prospective population-based study.

Clin Nutr

January 2025

Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA. Electronic address:

Background & Aims: Transitioning to more plant-based diets promotes environmental sustainability and has health benefits for adults. However, associations with nutrient intake adequacy and growth in children remain unknown. This study aimed to examine associations of plant-based diets with nutrient intake levels among children, and with longitudinal growth and body composition up to adolescence.

View Article and Find Full Text PDF

Double-stranded RNA orbivirus disrupts the DNA-sensing cGAS-sting axis to prevent type I IFN induction.

Cell Mol Life Sci

January 2025

Centro de Investigación en Sanidad Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CISA-INIA-CSIC), Valdeolmos, Madrid, Spain.

Cyclic GMP-AMP synthase (cGAS) is a DNA sensing cellular receptor that induces IFN-I transcription in response to pathogen and host derived cytosolic DNA and can limit the replication of some RNA viruses. Some viruses have nonetheless evolved mechanisms to antagonize cGAS sensing. In this study, we evaluated the interaction between Bluetongue virus (BTV), the prototypical dsRNA virus of the Orbivirus genus and the Sedoreoviridae family, and cGAS.

View Article and Find Full Text PDF

Arctic ecosystems are affected by accelerated warming as well as the intensification of the hydrologic cycle, yet understanding of the impacts of compound climate extremes (e.g., simultaneous extreme heat and rainfall) remains limited, despite their high potential to alter ecosystems.

View Article and Find Full Text PDF

Deciphering Plant NLR Genomic Evolution: Synteny-Informed Classification Unveils Insights into TNL Gene Loss.

Mol Biol Evol

January 2025

State Key Laboratory for Crop Stress Resistance and High-Efficiency Production/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling 712100, China.

Nucleotide-binding leucine-rich repeat receptor (NLR) genes encode a pivotal class of plant immune receptors. However, their rampant duplication and loss have made inferring their genomic evolutionary trajectory difficult, exemplified by the loss of TNL family genes in monocots. In this study, we introduce a novel classification system for angiosperm NLR genes, grounded in network analysis of micro-synteny information.

View Article and Find Full Text PDF

Return to On-Snow Performance in Ski Racing After Anterior Cruciate Ligament Reconstruction.

Am J Sports Med

January 2025

Integrative Neuromuscular Sport Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.

Background: The individual variation in on-snow performance outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) in elite alpine ski racers has not been reported and may be influenced by specific injury characteristics.

Purpose: To report the performance statistics of elite ski racers before and after ACLR and to identify surgical and athlete-specific factors that may be associated with performance recovery.

Study Design: Descriptive epidemiological study.

View Article and Find Full Text PDF

Background: The human gut microbiome strongly influences host metabolism by fermenting dietary components into metabolites that signal to the host. Our previous work has shown that Intestinimonas butyriciproducens is a prevalent commensal bacterium with the unique ability to convert dietary fructoselysine to butyrate, a well-known signaling molecule with proven health benefits. Dietary fructoselysine is an abundant Amadori product formed in foods during thermal treatment and is part of foods rich in dietary advanced glycation end products which have been associated with cardiometabolic disease.

View Article and Find Full Text PDF

International expert consensus on micronutrient supplement use during the early life course.

BMC Pregnancy Childbirth

January 2025

Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam, 3015 CE, Netherlands.

Background: Growing evidence demonstrates that maternal nutrition is crucial for the health of the mother-to-be, and early life course of the offspring. However, for most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate the level of expert consensus on maternal nutrition and micronutrient needs during preconception, pregnancy and lactation.

View Article and Find Full Text PDF

Tidal marshes can contribute to nature-based shoreline protection by reducing the wave load onto the shore and reducing the erosion of the sediment bed. To implement such nature-based shoreline erosion protection requires the ability to quickly restore or create highly stable and erosion-resistant tidal marshes at places where they currently do not yet occur. Therefore, we aim to identify the drivers controlling the rate by which sediment stability builds up in young pioneer marshes.

View Article and Find Full Text PDF

The concepts of irreversibility and reversibility in research on anthropogenic environmental changes.

PNAS Nexus

January 2025

Philosophy Group, Section CPTE (Communication, Philosophy, Technology, and Education), Wageningen University & Research, 6706 KN Wageningen, Netherlands.

The concept of "irreversibility" and its counterpart "reversibility" have become prominent in environmental and ecological research on human-induced changes, thresholds, climate tipping points, ecosystem degradation, and losses in the cryosphere and biosphere. Through a systematic literature review, we show that in these research fields, these notions are not only descriptive terms, but can have different semantic functions and normative aspects. The results suggest that, in the context of environmental and ecological research the concepts of irreversibility and reversibility have taken on additional usages in comparison to their contexts in theoretical thermodynamics and mechanics.

View Article and Find Full Text PDF

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

View Article and Find Full Text PDF

The ambition to utilize agricultural by-products has spotlighted tomato leaves as a promising source for plant-based proteins. High-yielding protein extractability is key for its industrial use, but previous studies reported decreased protein extractability at later stages of plant development. This study investigated the underlying factors in protein extractability through a comprehensive proteomics analysis across four plant developmental stages (vegetative, flowering, fruit-forming, mature-fruit).

View Article and Find Full Text PDF

Background: Broiler chickens are most vulnerable immediately after hatching due to their immature immune systems, making them susceptible to infectious diseases. The yolk plays an important role in early immune defence by showing relevant antioxidant and passive immunity capabilities during broiler embryonic development. The immunomodulatory effects of phytogenic compound carvacrol have been widely reported.

View Article and Find Full Text PDF