miR-193b-5p and miR-374b-5p Are Aberrantly Expressed in Endometriosis and Suppress Endometrial Cell Migration In Vitro.

(1) Background: Endometriosis is a highly prevalent gynecological disease affecting 10% of women of reproductive age worldwide. miRNAs may play a role in endometriosis, though their exact function remains unclear. This study aimed to identify differentially expressed miRNAs in endometriosis and study their functions in the disease.

Validation of the Mental Illness: Clinicians' Attitudes Scale: The Factor Structure and Psychometric Properties of the Brazilian Version.

Background/objectives: In the literature, few instruments have been identified to measure the stigma of health professionals toward people with mental illness. In Brazil, until 2021, the literature did not indicate the validation of an instrument or the construction of an instrument for this purpose. Considering this gap, this study aimed to validate and estimate the reliability of the Mental Illness: Clinicians' Attitudes Scale, version 4 (MICA-4) for the Brazilian context, examining the psychometric properties through the analysis of its internal consistency and factor structure.

African Schistosomiasis: A Framework of Indicators Assessing the Transmission Risk and Intervention Effectiveness.

Schistosomiasis, a parasitic disease with a complex transmission mechanism, requiring a snail intermediate host, is influenced by biology, the environment, human behavior and the prevailing socioeconomic situation. This study aimed to systematically investigate the importance and feasibility of indicators related to the factors influencing transmission and intervention measures for and . Based on a literature review and group discussions according to the Delphi method, a framework questionnaire was designed.

Lassa fever outbreaks, mathematical models, and disease parameters: a systematic review and meta-analysis.

Background: Understanding the epidemiological parameters and transmission dynamics of Lassa fever, a significant public health threat in west Africa caused by the rodent-borne Lassa virus, is crucial for informing evidence-based interventions and outbreak response strategies. Therefore, our study aimed to collate and enhance understanding of the key epidemiological parameters of Lassa fever.

Methods: We conducted a systematic review, searching PubMed and Web of Science for peer-reviewed studies published from database inception up to June 13, 2024, to compile and analyse key epidemiological parameters, mathematical models, and outbreaks of Lassa fever.

Evidence-based Guidelines for Keratorefractive Lenticule Extraction Surgery.

Topic: Development of evidence-based guidelines for keratorefractive lenticule extraction (KLEx).

Clinical Relevance: KLEx refers to various corneal refractive procedures involving removal of refractive lenticules of intrastromal corneal tissue, typically through a small incision, thereby eliminating creation of a corneal flap. This technique has rapidly gained popularity as a possible alternative to flap-based procedures; however, no clinical practice guidelines exist for KLEx.

Digital health and quality of care in Primary Health Care: an evaluation model.

Introduction: The implementation of technologies in Primary Health Care with monitoring and evaluation of the quality of health care is fundamental to direct the access and quality of health care in the context of the Sustainable Development Goals. Our objective was to develop a model for evaluating digital health interventions in primary care, considering its impact on first contact, longitudinality, integrality and coordination in health.

Methodology: This is an exploratory methodological study of a qualitative nature.

Can health impact assessment help tackle commercial determinants of health and support a wellbeing economy?

Commercial activity has positive and negative effects on health. Adverse commercial impacts on health are underpinned by corporate power and economic models and policy that prioritize economic growth, rather than a wellbeing economy that prioritizes health, equity and sustainability. Health in all policies (HiAP) aims to ensure that all policies promote health and health equity, using processes including health impact assessment (HIA).

Factors and reasons for planning to quit smoking among a nationally representative sample of adults who smoke: Findings from the 2021 ITC EUREST-PLUS Spain Survey.

Introduction: Intentions to quit are the strongest predictor of successful smoking cessation and future quit attempts. This study assesses factors associated with quit intentions among adults who smoke in Spain.

Methods: Data are from the 2021 International Tobacco Control (ITC) EUREST-PLUS Spain Wave 3 Survey, a nationally representative survey of adults aged ≥18 years who smoke (n=1006).

"A Man Has to Show That He Is a Man From a Young Age": Intimate Partner Violence for Young Male University Students in Brazil.

Considering that men today face social and cultural pressures to behave in certain ways, the objective of this study was to analyze the construction of Intimate Partner Violence (IPV) from the perspective of university students who identify themselves as male in a developing country. This is a qualitative study carried out through semi-structured interviews, with 15 students from the state of São Paulo, Brazil, from May to July 2021. The data were analyzed thematically and anchored in the ecological framework of understanding violence.

Enhancing culturally responsive care in perioperative settings for older adult patients: A qualitative interview study.

Background: Older adults aged over 65 are increasingly admitted to hospital for acute care reasons, including surgical procedures. In multicultural societies, the diversity of an ageing population has significant implications for the planning and delivery of culturally responsive perioperative care for older adults from ethnically diverse backgrounds, who are admitted to hospital for surgical intervention.

Objective: To explore the perspectives and experiences of perioperative staff when caring for older adult patients from ethnically diverse backgrounds.

Central venous catheter-related infections: a systematic review, meta-analysis, trial sequential analysis and meta-regression comparing ultrasound guidance and landmark technique for insertion.

Background: During central venous catheterization (CVC), ultrasound (US) guidance has been shown to reduce mechanical complications and increase success rates compared to the anatomical landmark (AL) technique. However, the impact of US guidance on catheter-related infections remains controversial. This systematic review and meta-analysis aimed to compare the risk of catheter-related infection with US-guided CVC versus AL technique.

Recommendations for Research to Develop a Patient-Centered Clinical Follow-Up Protocol for Oral Epithelial Dysplasia.

Oral epithelial dysplasia (OED) is the primary histological marker for assessing the progression of oral potentially malignant disorders (OPMDs) to cancer. Despite challenges in grading and low inter-pathologist reproducibility, OED severity remains the key predictor of malignant transformation. However, globally accepted guidelines for OED monitoring are lacking, despite calls for individualized management based on host and lesion characteristics.

No detrimental effect on the hand microbiome of health care staff by frequent alcohol-based antisepsis.

Background: The importance of ethanol-based hand rubs (EBHRs) to prevent health care-associated infections is undisputed. However, there is a lack of meaningful data regarding the influence of EBHRs on skin microbiome.

Methods: Four nurses in a neonatal intensive care unit were included.

Implications of the apparent extinction of B/Yamagata-lineage human influenza viruses.

Following the onset of the COVID-19 pandemic in 2020, the number of influenza viruses circulating globally fell to historically low numbers. Although influenza A and B/Victoria lineage viruses returned to normal patterns by 2022, B/Yamagata-lineage viruses have not been identified since 2020. The implications of the apparent extinction of this lineage of viruses on vaccine composition, and the risk of their re-introduction into the human population are discussed.

The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): The immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-<50 and 50-<70 years old.

Objectives: PICOBOO is a randomised, adaptive trial evaluating the immunogenicity, reactogenicity, and safety of COVID-19 booster strategies. Here, we present data for second boosters among individuals aged 18-<50 and 50-<70 years old primed with BNT162b2 until Day (D) 84.

Methods: Immunocompetent adults who had received two doses of BNT162b2 and any licensed COVID-19 booster at least three months prior were eligible.

Analysis of biomedical and health research in the Eastern Mediterranean Region.

Background: Several bibliometric analyses have been conducted in the Eastern Mediterranean Region (EMR), however, there is limited data from such analyses for the establishment of national or regional health research agenda.

Aim: To assess the biomedical and health research outputs in EMR countries for 2004-2018 and their alignment with the regional strategic health priority areas identified by the WHO Regional Office for the Eastern Mediterranean.

Methods: We searched and reviewed health-related articles indexed in PubMed and originating from EMR countries from 2004 to 2018 and used these as indicators of the country's total biomedical research publication level.