Two decades of capacity building to support global malaria control and elimination: retrospective and prospective international trainings in Jiangsu Institute of Parasitic Diseases, China, 2002-2021.

Background: Malaria is still one of the major infectious diseases affecting human health, and the World Health Organization (WHO) has attached special importance to malaria-related technical training for its global elimination efforts. The Jiangsu Institute of Parasitic Diseases (JIPD), designated as a WHO Collaborating Centre for Research and Training on Malaria Elimination, has conducted numerous international malaria training programmes during the last 2 decades.

Methods: A retrospective analysis of international training programmes organized and facilitated by JIPD in China since 2002 was conducted.

Priorities of China's participation in global malaria elimination: the perspective of malaria endemic countries.

Background: Malaria is one of the major diseases affecting global health, while progress in malaria control and elimination has stagnated in some endemic countries. China has been certificated malaria free by World Health Organization in 2021, and will get more involved on global malaria elimination. Further discussion is needed on how to collaborate with the malaria endemic countries and provide effective help.

[Study on emergency metabolic changes of larvae following exposure to deltamethrin].

Objective: To analyze the changes of small molecular metabolites in the larvae of a deltamethrin-sensitive strain of following exposure to deltamethrin, so as to provide the scientific basis for investigating the metabolic pathway and screening metabolic markers of deltamethrin in .

Methods: The 50% and 75% lethal concentrations (LC and LC) of deltamethrin against the larvae of a deltamethrin-sensitive strain of were calculated in laboratory. The type and content of larvae metabolites were detected using high performance liquid chromatography and mass spectrometry (LC-MS/MS) following exposure to deltamethrin at LC and LC for 30 min and 24 h, and the changes of metabolites were analyzed.

[Progress in researches on molecular markers of non- drug resistance].

With the long-term and widespread application of antimalarial drugs, has gradually produced resistance to antimalarial drugs. At present, there are more researches on the molecular markers of drug resistance, while less attention has been paid to the molecular markers of non- drug resistance. In order to provide the reference for rational drug use in clinical treatment and reference for molecular monitoring of antimalarial drug sensitivity of non-, this paper reviews the researches on the common molecular markers related to non drug resistance.