Transversality Conditions for Geodesics on the Statistical Manifold of Multivariate Gaussian Distributions.

We consider the problem of finding the closest multivariate Gaussian distribution on a constraint surface of all Gaussian distributions to a given distribution. Previous research regarding geodesics on the multivariate Gaussian manifold has focused on finding closed-form, shortest-path distances between two fixed distributions on the manifold, often restricting the parameters to obtain the desired solution. We demonstrate how to employ the techniques of the calculus of variations with a variable endpoint to search for the closest distribution from a family of distributions generated via a constraint set on the parameter manifold.

A charged diatomic triple-bonded U≡N species trapped in C fullerene cages.

Actinide diatomic molecules are ideal models to study elusive actinide multiple bonds, but most of these diatomic molecules have so far only been studied in solid inert gas matrices. Herein, we report a charged U≡N diatomic species captured in fullerene cages and stabilized by the U-fullerene coordination interaction. Two diatomic clusterfullerenes, viz.

Contact based intervention reduces stigma among pharmacy students.

Introduction: Interventions to reduce the stigma of substance use disorders by health professionals often include didactic instruction combined with an interactive component that includes a guest speaker in recovery. Few interactive studies have focused on pharmacy students. Community pharmacists are moving to the front lines to battle the opioid epidemic; therefore, pharmacy students should be included in interventions aimed at reducing stigma by health professionals.

Post-fire seed dispersal of a wind-dispersed shrub declined with distance to seed source, yet had high levels of unexplained variation.

Plant-population recovery across large disturbance areas is often seed-limited. An understanding of seed dispersal patterns is fundamental for determining natural-regeneration potential. However, forecasting seed dispersal rates across heterogeneous landscapes remains a challenge.

Ultrasensitive detection of acephate based on carbon quantum dot-mediated fluorescence inner filter effects.

Acephate is an organophosphorus pesticide (OP) that is widely used to control insects in agricultural fields such as in vegetables and fruits. Toxic OPs can enter human and animal bodies and eventually lead to chronic or acute poisoning. However, traditional enzyme inhibition and colorimetric methods for OPs detection usually require complicated detection procedures and prolonged time and have low detection sensitivity.

Steps toward Rationalization of the Enantiomeric Excess of the Sakurai-Hosomi-Denmark Allylation Catalyzed by Biisoquinoline N,N'-Dioxides Using Computations.

Allylation reactions of aldehydes are chemical transformations of fundamental interest, as they give direct access to chiral homoallylic alcohols. In this work, we focus on the full computational characterization of the catalytic activity of substituted biisoquinoline-N,N'-dioxides for the allylation of 2-naphthaldehyde. We characterized the structure of all transition states as well as identified the π stacking interactions that are responsible for their relative energies.

Combined Effects of Scarification, Phytohormones, Stratification, and Soil Type on the Germination and/or Seedling Performance of Three Tamaulipan Thornscrub Forest Species.

Tamaulipan thornforests in south Texas and northeast Mexico are a conservation hotspot. Shortages of native seedlings limit regional restoration and are largely driven by knowledge gaps regarding propagation of the 75+ thornforest species planted during restorations. We previously investigated three thornforest species with low or inconsistent germination or seedling survival: (Fabaceae), (Boraginaceae), and (Rutaceae), and identified the types and dosages of chemical seed treatments that maximized germination.

Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization.

Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress. For instance, the method of preparing ASDs evolved from solvent-based approaches to solvent-free methods such as hot melt extrusion and Kinetisol.

Detection of numerous phycotoxins in young bull sharks (Carcharhinus leucas) collected from an estuary of national significance.

Florida's Indian River Lagoon (IRL) has experienced large-scale, frequent blooms of toxic harmful algae in recent decades. Sentinel, or indicator, species can provide an integrated picture of contaminants in the environment and may be useful to understanding phycotoxin prevalence in the IRL. This study evaluated the presence of phycotoxins in the IRL ecosystem by using the bull shark (Carcharhinus leucas) as a sentinel species.

Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial.

Background: Methods of sustaining the deimplementation of overused medical practices (i.e., practices not supported by evidence) are understudied.

Pesticide exposure and cortical brain activation among farmworkers in Costa Rica.

Background: Previous epidemiological studies have reported associations of pesticide exposure with poor cognitive function and behavioral problems. However, these findings have relied primarily on neuropsychological assessments. Questions remain about the neurobiological effects of pesticide exposure, specifically where in the brain pesticides exert their effects and whether compensatory mechanisms in the brain may have masked pesticide-related associations in studies that relied purely on neuropsychological measures.

Electrostatics in Computational Biophysics and Its Implications for Disease Effects.

This review outlines the role of electrostatics in computational molecular biophysics and its implication in altering wild-type characteristics of biological macromolecules, and thus the contribution of electrostatics to disease mechanisms. The work is not intended to review existing computational approaches or to propose further developments. Instead, it summarizes the outcomes of relevant studies and provides a generalized classification of major mechanisms that involve electrostatic effects in both wild-type and mutant biological macromolecules.

Targeting Metal Impurities for the Detection and Quantification of Carbon Black Particles in Water via spICP-MS.

Carbon black (CB) is a nanomaterial with numerous industrial applications and high potential for integration into nano-enabled water treatment devices. However, few analytical techniques are capable of measuring CB in water at environmentally relevant concentrations. Therefore, we intended to establish a quantification method for CB with lower detection limits through utilization of trace metal impurities as analytical tracers.

Testosterone, cortisol, and criminal behavior in men and women.

Only two studies to date have considered the joint effects of testosterone and cortisol on direct measures of criminal behavior. The current study extends this earlier work by incorporating the direct and interactive effects of baseline hormone measures and hormone change scores in response to social stress. The current study also extends prior work by considering distinct measures of different criminal behavior types and sex differences.

Crystallization, Phase Stability, Microstructure, and Chemical Bonding in GaO Nanofibers Made by Electrospinning.

We report on the crystal structure, phase stability, surface morphology, microstructure, chemical bonding, and electronic properties of gallium oxide (GaO) nanofibers made by a simple and economically viable electrospinning process. The effect of processing parameters on the properties of GaO nanofibers were evaluated by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. Thermal treatments in the range of 700-900 °C induce crystallization of amorphous fibers and lead to phase stabilization of α-GaOOH, β-GaO, or mixtures of these phases.

The temporal dynamics of bilingual language control.

Bilinguals need to control interference from the nontarget language, to avoid saying words in the wrong language. This study investigates how often bilinguals apply such control in a dual-language mode, when speaking one language after the other when the two languages cannot be used interchangeably: over and over (every time they say a word), or only once (the first time they use a word or language after a language switch). Three groups of Spanish-English bilinguals named pictures first in their dominant, then in their nondominant, and then again in their dominant language; a fourth control group of bilinguals named pictures in their dominant language throughout.

Systematics of the Central African Spiny Reed Frog Afrixalus laevis (Anura: Hyperoliidae), with the description of two new species from the Albertine Rift.

The geographically widespread species Afrixalus laevis (Anura: Hyperoliidae) currently has a disjunct distribution in western Central Africa (Cameroon, Equatorial Guinea, Gabon, and possibly adjacent countries) and the area in and near the Albertine Rift in eastern Democratic Republic of the Congo and neighboring countries. At least two herpetologists have previously suggested that these disjunct populations represent distinct species, and herein, we utilize an integrative taxonomic approach with molecular and morphological data to reconcile the taxonomy of these spiny reed frogs. We sequenced 1554 base pairs of the 16S and RAG1 genes from 34 samples of A.

Effects of a soccer-specific vertical jump on lower extremity landing kinematics.

Anterior cruciate ligament (ACL) injury frequently occurs in female soccer athletes during deceleration movements such as landings. In soccer, landings mostly occur following jumping headers. Little research has been done to determine the mechanics that follow and how they compare to standard drop vertical jumps (DVJ).

Virtual Screening of Alkaloid and Terpenoid Inhibitors of SMT Expressed in sp.

The pathogenic form of thermophilic Naegleria sp. i.e.

Early Childhood Education Teacher Well-Being: Performativity as a Means of Coping.

Unlabelled: Detrimental circumstances (e.g., poverty, homelessness) may affect parents, parenting, and children.

Interventions for Health Promotion and Obesity Prevention for Children and Adolescents with Developmental Disabilities: a Systematic Review.

Unlabelled: This systematic review evaluated interventions and relevant outcomes for health promotion and obesity prevention among children and adolescents with developmental disabilities (DD). Twenty-one studies including randomized control trials (= 9) and quasi-experimental studies (=12) published between 2010 and 2021 met inclusion criteria related to participant characteristics, intervention type, and child obesity-related outcomes. Five types of intervention programs were identified: aerobic and strength training, sport-based physical activity, aquatic exercise, active video gaming, and diet and lifestyle.

Metastatic cancer and multiple myeloma: One ancient, the other a disease of modernity?

Diagnostic caveats have often been incorporated in publications suggesting possible multiple myeloma in archeological sites, noting difficulty distinguishing it from metastatic cancer. It seems appropriate to assess whether suggested cases in the archeological record differ from what modern medicine recognizes/diagnoses. The published literature and archives were surveyed for reports of multiple myeloma in archeological sites.

Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation.

Research integrating molecular and imaging data provides important insights into how the genetic profile associated with dopamine signaling influences inter-individual differences in brain functions. However, the effects of genetic variations in dopamine signaling on the heterogeneity of brain changes induced by repetitive transcranial magnetic stimulation (rTMS) still remain unclear. The current study examined the composite effects of genetic variations in dopamine-related genes on rTMS-induced brain responses in terms of the functional network connectivity and working memory performance.

Collar-button abscess as a complication of infected hematoma in the setting of uncontrolled type 2 diabetes.

Introduction: Collar-button abscesses are deep space infections of the hand.

Case Presentation: We present a case of a 66-year-old man who developed an acute collar-button abscess of the hand after a concrete bench fell onto the dorsal aspect of his hand. The hand abscess was managed successfully with intravenous antibiotics and operative intervention.

Playing it by ear: gregarious sparrows recognize and respond to isolated wingbeat sounds and predator-based cues.

The ability to detect an incoming attack provides a final opportunity for an animal to avoid predation. In birds, vision is the main sensory mode in detecting attacks, but auditory cues likely play an important role. The role of auditory cues from predators themselves remains largely unstudied.