[Efficacy, tolerability and safety of the treatment with teberif: the results of a 2-year randomized clinical trial of treatment naïve patients with remitting multiple sclerosis, who have not received DMT, after switching from other interferon β-1a].

Objectives: To evaluate efficacy, safety, and tolerability of the treatment with teberif/interferon β-1a, to analyze safety, tolerability and dynamics of key efficacy variables after switching from referent drug rebif to biosimilar teberif in patients with remitting multiple sclerosis (RMS).

Material And Methods: During the main period of the international multicenter randomized study patients were randomized to receive treatment with teberif for 52 weeks, or rebif for 52 weeks, or placebo for 16 weeks to evaluate efficacy and safety of treatment. After the main study period, patients were group-independently switched to take open-label teberif treatment during the next 48 weeks.

[Granulocytes function in patients with chronic venous insufficiency followed by chronic wounds].

Aim: To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency.

Material And Methods: There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed.

[Proliferative activity of paravasal connective tissue cells in the age aspect.].

The aim of the study was to investigate the age-related variability of the proliferative activity of fibroblasts of the paravasal connective tissue of the hollow and parenchymal organs of men corpses of the first period of mature age, elderly and senile age by detecting the expression of the Ki-67 protein (MIB-1 clone) and calculating the proliferation index. The results showed that in the first period of mature age, the proliferation index is almost at the same level in the paravasal tissue cells of the parenchymal and hollow organs of the digestive tract, while the fibroblasts of the paravasal tissue of the heart have the lowest proliferation activity among all the organs studied. With age, the intensity of cell proliferation decreases, moreover, at the age of more than 75 years, a distinct organ specificity is revealed.

[The Development of Specialized Medical Care of Patients With Maxillofacial Trauma].

The purpose of study is to substantiate activities concerning development of specialized medical care of victims with injuries of maxillofacial area. The study was organized on the base of the Krasnoyarsk kraii clinical hospital, a leading institution providing medical care of victims with injuries of maxillofacial area in the Krasnoyarsk kraii. The study used analytical, sociological (survey), statistical methods and expert evaluation technique.

[Possibilities of retention of work capacity in patients with Parkinson's disease].

Aim: To study the efficacy of replacement of the single daily dose of two-component levodopa by three-component levodopa in work capable patients with Parkinson's disease with motor fluctuations during the most active working hours.

Material And Methods: The study included 157 patients from 19 Russian centers specialized in extrapyramidal pathology. The period of highest working activity was analyzed in all patients.

[Predictors of hepatic insufficiency in obstructive jaundice].

Aim: To develop predictive model for hepatic insufficiency in obstructive jaundice.

Material And Methods: Obstructive jaundice was modeled by the author's method on 48 mini pigs, while morpho-functional features of erythrocytes were studied by using of INTEGRA Aura atomic force microscope (NT-MDT, Zelenograd, Russia). Histological specimens were stained with hematoxylin and eosin.

[ACOS: Clinical and functional features The Russian formulation mesalazine (kansalazine) in the therapy of ulcerative colitis].

Aim: To investigate the clinical and functional parameters in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) versus those with chronic obstructive pulmonary disease (COPD) and asthma.

Subjects And Methods: A total of 129 people were examined. 51 patients with ACOS were followed up in Group 1; Group 2 included 38 patients with severe asthma; Group 3 consisted of 40 patients with severe COPD.

[The optimization of restoration approaches of advanced hand activity using the sensorial glove and the mCIMT method].

Aim: To reason the choice of methods of restoration of advanced hand activity depending on severity of motor disturbance in the top extremity.

Material And Methods: Eighty-eight patients were randomized into 3 groups: 1) the mCIMT group, 2) the 'touch glove' group, 3) the control group. For assessment of physical activity of the top extremity Fugl-Meyer Assessment Upper Extremity, Nine-Hole Peg Test, Motor Assessment Scale were used.

Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels.

The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.

[Types of immune response in advanced suppurative peritonitis].

Aim: to assess types of immune response in patients with advanced suppurative peritonitis and course of disease.

Material And Methods: We examined 79 patients with acute surgical abdominal diseases and injuries complicated by advanced suppurative peritonitis. Blood immunological parameters were estimated using flowing cytometry and enzyme immunoassay.

Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia.

We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.

[Possibilities of non-drug treatment for Parkinson's disease].

In this article, non-drug methods of treatment of Parkinson's disease are reviewed. Particular attention is given to the motor symptoms of disease, specifically to gait disorders. Information about objective methods of gait impairment is presented.

Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules.

We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.

[Prevention and treatment of post-traumatic pancreatic necrosis in patients with blunt abdominal trauma].

Introduction: High incidence of necrotic and suppurative complications is feature of acute post-traumatic pancreatitis. Severe trauma of the pancreas and post-traumatic pancreatitis lead to depressurization of ductal system that requires adequate drainage of damaged area and retroperitoneal fat.

Material And Methods: 95 patients in group 1 received standardized treatment.

[Predictors and modifiers of impulse control disorders in Parkinson`s disease].

Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized psychiatric complication in Parkinson's disease (PD). ICDs have been most closely related to the use of dopamine agonists (DAs), perhaps more so at higher doses. Possible predictor's for ICDs include male sex, younger age and younger age at PD onset, use of dopaminergic agents.

[Evaluation of a method based on the principle of CI therapy in the correction of walking function in patients with post-stroke hemiparesis syndrome].

Aim: To develop a new, effective, affordable method of neurorehabilitation for the correction of walking functions based on the principle of CI (constraint-induced movement therapy) therapy in patients with the syndrome of hemiparesis of post-stroke origin.

Material And Methods: The study included 100 patients with moderate to marked syndrome of central hemiparesis in the recovery period of stroke. Patients were randomized into two groups.

[The investigation of kinematic features of gait in healthy subjects and patients with post-stroke atactic disorders].

Aim: To study spatial/temporal parameters of gait in post-stroke vestibular-atactic syndrome.

Material And Methods: Authors investigated the speed, rhythmic and angle parameters of the gait in healthy subjects (n=15) and in patients with atactic disorders in the recovery period of vertebrobasillar ischemic stroke (n=15). Physical examination with elements of anthropometry, clinical assessment of gait function with the Dynamic Gait Index, objective assessment of gait parameters using the system for 3D movement video analysis VICON Motion Capture Systems were used.

Expression of Glutamate and Glutamine Transporter Proteins in Neurovascular Unit Cells In Vitro.

Glutamine transporter protein SLC1A5 and glutamate transporter protein EAAT2 responsible for cell-cell communication and energetic coupling were studied using in vitro model of multicellular neurovascular unit consisting of astrocytes, neurons, and endotheliocytes under standard conditions and during chemical hypoxia in vitro. Hypoxic damage to the neurovascular unit cells increased the number of SLC1A5-expressing cells and reduced the number of EAAT2-expressing astrocytes. Metabolic uncoupling in the neurovascular unit cells under hypoxic conditions resulted from abnormal expression of glutamine and glutamate transporter proteins, which is indicative of impaired glutamine and glutamate transport.

[Analysis of the state-of-the-art of consulting medical care to patients with glucocorticoid-induced osteoporosis or its risk according to the data of a questionnaire survey (GLUCOST study)].

Aim: To analyze the state-of-the-art of consulting medical care to Russian patients with glucocorticoid-induced osteoporosis (GCOP) or its risk.

Subjects And Methods: This GLUCOST study was organized and conducted by the Russian Association of Osteoporosis. A total of 1129 patients with chronic inflammatory diseases, who had been taking oral glucocorticosteroids (OGCSs) a long time (3 months or more), were examined.

[An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders].

Objective: To explore the dynamics of hemostasis in patients with acute coronary syndrome (ACS) in the combination with anxiety and depressive disorders (ADD) during therapy with valdoxan (agomelatine).

Material And Methods: We examined 196 male and female patients (mean age 64.2 ± 0.

[The results of the multicenter pharmaco-epidemiological observational project on the use of mydocalm in the treatment of pain syndromes with the muscle spasm].

The prospective multicenter open noncomparative pharmaco-epidemiological observational project on the use of mydocalm in real clinical practice has been completed in 2013. The project has been performed in 2090 clinical/rehabilitation settings in 284 cities of 13 countries using the results of 35,383 patients. The project aimed to assess the safety of treatment (percentage of patients with adverse-effects) and pain relieving efficacy as well as patient's satisfaction with the treatment.

Lipid peroxidation and antioxidant system in erythrocytes of patients with renal cell carcinoma.

For evaluation lipid peroxidation and antioxidant status of red blood cells, 150 patients with locally advanced renal cell carcinoma were examined. The content of conjugated dienes, MDA, and reduced glutathione and activities of SOD, catalase, and glutathione metabolism enzymes were determined. It was found that the balance between pro- and anti-oxidants in patients with kidney cancer differed significantly from that of healthy people and little changed during the observation.

Morphological study of burn wound healing with the use of collagen-chitosan wound dressing.

Experiments on the model of thermal skin burn in rats showed that the use of wound dressing based on collagen-chitosan complex Kollakhit-Bol in local treatment of grade IIIb skin burns increased healing rate by accelerating the formation of granulation and fibrous connective tissues and reducing crust thickness in comparison with Kollakhit coating. Kollakhit-Bol provided targeted stimulation of reparative processes in the treatment of grade IIIb burns by creating favorable conditions for grafting full thickness skin transplant or dermal-epidermal skin equivalent. In the topical treatment of thermal burn, Kollakhit-Bol application shortened the phases of alteration and exudation and accelerated transition to the productive phase of the inflammatory process with phagocytosis and neoangiogenesis activation.

Analysis of the application of MMP-9 inhibitor in skin melanoma: experimental study.

Experiment on C57Bl/6 mice with modeled skin melanoma showed that selective inhibition of matrix metalloproteinase-9 increased lifetime and reduced the number of PCNA(+) tumor cells and intensity of neoangiogenesis. Inhibition of matrix metalloproteinase-9 prevented tumor necrosis. The results suggest that matrix metalloproteinase-9 is involved not only in the regulation of extracellular matrix degradation, but also in the processes of cell proliferation and neoangiogenesis in skin melanoma.