5,189 results match your criteria: "Von Hippel-Lindau Syndrome"
Abdom Radiol (NY)
December 2024
Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, No.58, Second Zhongshan Road, Yuexiu District, Guangzhou, Guangdong, 510080, China.
Pancreatic neuroendocrine neoplasms (pNENs) are the second most common pancreatic malignancy. While most cases are sporadic, a small proportion is associated with genetic syndromes, such as Multiple Endocrine Neoplasia (MEN), Von Hippel-Lindau Syndrome (VHL), Neurofibromatosis Type 1 (NF1), and Tuberous Sclerosis Complex (TSC). This review aims to use pNENs as a clue to reveal the full spectrum of disease, providing a comprehensive understanding of diagnosis.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.
Clear cell renal cell carcinoma is the most common form of kidney cancer, accounting for 75% of malignant kidney tumors, and is generally associated with poor patient outcomes. With risk factors including smoking, obesity, and hypertension, all of which have a high prevalence in the United States and Europe, as well as genetic factors including tuberous sclerosis complex and Von Hippel-Lindau syndrome, there is an increasing need to expand our present understanding. The current clear cell renal cell carcinoma knowledge is outdated, with obsolete diagnostic criteria and moderately invasive surgical treatments still prevailing, partially ascribed to its resistance to chemotherapy and radiation therapy.
View Article and Find Full Text PDFJ Kidney Cancer VHL
December 2024
Department of Urology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Von Hippel-Lindau (vHL) is a hereditary disease characterized by the development of benign and malignant tumors across multiple organ systems. It is seen in approximately 1 in 36,000 live births. Given that vHL is a rare disease, studies that seek to characterize vHL are often hampered by small sample sizes.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
December 2024
Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy. Electronic address:
Renal cell carcinoma (RCC) constitutes the most frequent kidney cancer of the adult population and one of the most lethal malignant tumors worldwide. RCC often presents without early symptoms, leading to late diagnosis. Prognosis varies widely based on the stage of cancer at diagnosis.
View Article and Find Full Text PDFMagy Onkol
December 2024
Gyermekgyógyászati Klinika, Semmelweis Egyetem, Tűzoltó utcai Részleg, Budapest, Hungary.
RASopathies are congenital diseases that manifest in childhood with symptoms and potential complications, typically associated with an elevated tumour predisposition risk. The heterogeneous symptoms involve mostly central nervous, cardiovascular, musculoskeletal systems and skin, and modified growth pattern. From molecular perspective, the function of a key protein involved in Ras signalling is impaired, leading to disrupted regulation of cell growth and division.
View Article and Find Full Text PDFZh Vopr Neirokhir Im N N Burdenko
December 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Hemangioblastoma (HAB) is a benign, richly vascularized tumor that accounts for 2-6% of all spinal cord neoplasms and ranks third in the structure of intramedullary space-occupying lesions of the spinal cord. Hemangioblastoma may occur sporadically or, in approximately 30% of cases, as part of the clinical picture of a hereditary disease, von Hippel-Lindau disease. The aim of this study was to evaluate the efficacy and safety of stereotactic irradiation of hemangioblastomas of the spinal localization in patients with sporadic and von Hippel-Lindau-associated hemangioblastomas The results of stereotactic radiotherapy were evaluation of 210 spinal hemangioblastomas in 74 patients.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Background: Lysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role in the development of tumors. Clear cell Renal Cell Carcinoma (ccRCC) is still the most common pathological type of renal carcinoma with poor prognosis. However, the expression of LAMP1 and its underlying molecular mechanism with ccRCC remain elusive.
View Article and Find Full Text PDFN Z Med J
December 2024
Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, New Zealand.
Front Oncol
November 2024
Department of Otolaryngology Head and Neck Surgery, Medical University of Lublin, Lublin, Poland.
Front Oncol
November 2024
Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
J Kidney Cancer VHL
November 2024
Department of Medicine IV - Nephrology and Primary Care, University of Freiburg, Germany.
Early identification of patients at risk with von Hippel-Lindau (VHL) syndrome-related pheochromocytoma and paraganglioma (PPGL) is crucial to prevent morbidity. We investigated the current surveillance recommendations in VHL-related PPGL in children and adolescents. German Pediatric Oncology and Hematology-Malignant Endocrine Tumor registry (GPOH-MET) and Freiburg-VHL registry (1996-2022).
View Article and Find Full Text PDFHepatol Commun
December 2024
Department of Minimally Invasive Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: Ischemia and reperfusion (I/R)-induced liver injury contributes to morbidity and mortality during hepatic surgery or liver transplantation. As a pivotal regulator of cancer and inflammation, the role of Von Hippel-Lindau (VHL) in hepatic I/R injury remains undetermined.
Methods: We investigated the role of VHL in hepatic I/R injury by generating VHL conditional knockout (VHL-KO) mice.
Biochem Soc Trans
December 2024
Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah, Biomedical Centre, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, U.K.
Transl Oncol
January 2025
Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, PR China. Electronic address:
New Microbiol
November 2024
Infectious Diseases Unit, "Alessandro Manzoni" Hospital, ASST-Lecco, Lecco, Italy.
Only toxigenic serogroups O1 and O139 Vibrio cholerae have been associated with widespread cholera epidemics. Other serogroups (non-O1/non-O139 Vibrio cholerae or NOVC) most often cause sporadic gastrointestinal manifestations. Rarely, NOVC can result in severe extraintestinal manifestations in immunocompromised hosts.
View Article and Find Full Text PDFStem Cell Res
December 2024
Human Embryo and Stem Cell Unit, The Francis Crick Institute, London, UK. Electronic address:
VHL disease is an inherited and autosomal dominant disorder affecting 1 in 36,0000 individuals worldwide. It is caused by von Hippel-Lindau (VHL) gene mutations and can affect both genders and all ethnic backgrounds (Nordstrom-O'Brien et al., 2009; Maher, 2004).
View Article and Find Full Text PDFWorld Neurosurg
November 2024
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, Beijing, China. Electronic address:
BMJ Case Rep
November 2024
Ophthalmology, Mata Gujri Memorial Medical College and LSK Hospital, Kishanganj, Bihar, India.
Biochim Biophys Acta Mol Basis Dis
January 2025
Institute of Biotechnology, Czech Academy of Sciences, 252 50 Prague-West, Czech Republic; Faculty of Science, Charles University, 128 00 Prague, Czech Republic; School of Pharmacy and Medical Science, Griffith University, Southport, Qld 4222, Australia; First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic. Electronic address:
Autophagy
November 2024
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Clear cell renal cell carcinoma (ccRCC) is tightly associated with (von Hippel-Lindau tumor suppressor) mutation and dysregulated angiogenesis. Accumulating evidence indicates that antiangiogenic treatment abolishing tumor angiogenesis can achieve longer disease-free survival in patients with ccRCC. Atractylenolide I (ATL-I) is one of the main active compounds in root extract and exhibits various pharmacological effects, including anti-inflammatory and antitumor effects.
View Article and Find Full Text PDFChin Med Sci J
September 2024
Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medicine Science, Beijing 100730, China.
Neuroimaging Clin N Am
November 2024
Department of Radiology, Neurology & Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Section of Interventional Neuroradiology, Department of Radiology, Northwestern Memorial Hospital, 676 North Street, Clair street, Suite 1400, Chicago, IL 60611, USA.
Biomedicines
October 2024
Department of Clinical and Experimental Sciences, University of Brescia, Clinical Research Hospital, IRCCS Multimedica, Sesto San Giovanni, 20099 Milan, Italy.
Dtsch Med Wochenschr
November 2024
Klinik II für Innere Medizin - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Köln, Deutschland.
While genetic kidney diseases were long regarded as a rare cause of kidney failure, it has been shown in recent years that they account for a relevant proportion of cases. In cohorts of kidney transplant recipients, a monogenic cause is found in up to 30% of cases. Identifying the genetic cause of kidney disease has become much easier thanks to technological advances in DNA sequencing.
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