5 results match your criteria: "Viterbi School of Engineering of the University of Southern California[Affiliation]"
Frame to Improve the Fit of N95 Filtering Face Mask Respirators.
J Occup Environ Med
June 2021
Department of Respiratory and Interventional Pulmonology, Keck Medical Center of the University of Southern California (Mr Stemen); Caruso Department of Otolaryngology-Head and Neck Surgery (Dr Ge, Dr Ference); Department of Radiology (Dr Hwang); Department of Biomedical Engineering, Viterbi School of Engineering of the University of Southern California (Dr Hwang); Tetra Bio Distributed (Mr Qaddoumi, Dr Roden; Section of Infectious Disease, Department of Medicine (Dr Nanda), Keck School of Medicine of the University of Southern California, Los Angeles, California.
Objective: Test a device that can improve upon the seal of filtering face mask respirators (FFRs).
Methods: A 3-D prototype for a fit improvement frame (FIF) was created and quantitative fit testing was performed for FFRs with and without the FIF.
Results: Thirty eight volunteers underwent fit testing.
The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.
Nanomedicine
February 2020
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy of the University of Southern California, Los Angeles, CA 90089, USA; Department Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering of the University of Southern California, Los Angeles, CA 90033, USA. Electronic address:
Humanin (HN) is a hydrophobic 24-amino acid peptide derived from mitochondrial DNA that modulates cellular responses to oxidative stress and protects human retinal pigment epithelium (RPE) cells from apoptosis. To solubilize HN, this report describes two genetically-encoded fusions between HN and elastin-like polypeptides (ELP). ELPs provide steric stabilization and/or thermo-responsive phase separation.
View Article and Find Full Text PDFSympathetic Effects of Internal Carotid Nerve Manipulation on Choroidal Vascularity and Related Measures.
Invest Ophthalmol Vis Sci
October 2019
USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States.
Purpose: To investigate specific effects of denervation and stimulation of the internal carotid nerve (ICN) on the choroid and retina.
Methods: Female Sprague Dawley rats underwent unilateral ICN transection (n = 20) or acute ICN electrical stimulation (n = 7). Rats in the denervation group were euthanized 6 weeks after nerve transection, and eyes were analyzed for changes in choroidal vascularity (via histomorphometry) or angiogenic growth factors and inflammatory markers (via ELISA).
Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis.
Front Pharmacol
October 2018
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy of the University of Southern California, Los Angeles, CA, United States.
Rapamycin (Rapa) is a highly potent drug; however, its clinical potential is limited by poor solubility, bioavailability, and cytotoxicity. To improve Rapa delivery, our team has fused the cognate protein receptor for Rapa, FKBP12, to high molecular weight elastin-like polypeptides (ELPs). One construct, FAF, includes an FKBP domain at each termini of an ELP.
View Article and Find Full Text PDFIntra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration.
J Control Release
August 2018
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy of the University of Southern California, Los Angeles, CA 90089, USA; Department Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering of the University of Southern California, Los Angeles, CA 90033, USA. Electronic address:
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible central vision loss, and the primary site of AMD pathology is the retinal pigment epithelium (RPE). Geographic atrophy (GA) is an advanced form of AMD characterized by extensive RPE cell loss, subsequent degeneration of photoreceptors, and thinning of retina. This report describes the protective potential of a peptide derived from the αB crystallin protein using a sodium iodate (NaIO) induced mouse model of GA.
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