4,082 results match your criteria: "Vitamin E Deficiency"
Ataxia With Vitamin E Deficiency: Case Series, Vitamin E Therapy Response, Founder Effect, and In Silico Analysis.
Clin Genet
December 2024
Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran.
Ataxia with Vitamin E Deficiency (AVED) is a rare autosomal recessive genetic disorder, that caused by pathogenic variants in the TTPA gene, which encodes the alpha-tocopherol transfer protein. This study investigates eight patients from three consanguineous Iranian families, using exome sequencing (ES) and Sanger sequencing to identify novel pathogenic variants in the TTPA gene. Two variants were identified: c.
View Article and Find Full Text PDFCorrelation Between Vitamin E Levels and Cholesterol, Vitamin D, and Frequency of Pulmonary Exacerbations in Children With Cystic Fibrosis.
Cureus
November 2024
Department of Public Health, The Ministry of Health, Manama, BHR.
Introduction Children with cystic fibrosis (CF) have lipid maldigestion due to pancreatic insufficiency, which causes malabsorption of fat-soluble vitamins. The primary objective of this study was to assess the prevalence of vitamin E deficiency among children with CF. The secondary objective was to examine the correlation between vitamin E levels with demographic data, laboratory findings, and the number of pulmonary exacerbations.
View Article and Find Full Text PDFOverweight Leads to an Increase in Vitamin E Absorption and Status in Mice.
Mol Nutr Food Res
December 2024
Aix-Marseille Université, INRAE, INSERM, C2VN, Marseille, France.
Article Synopsis
- This study looks into why obese individuals may have low vitamin E (VE) levels, specifically whether it's due to issues with how VE is absorbed in the intestines.
- After 12 weeks of a high-fat diet, mice showed increased weight and fat levels compared to those on a control diet, but surprisingly, they had higher levels of α-tocopherol (a form of vitamin E) in their blood and liver.
- The results suggest that even with obesity, these mice actually absorb vitamin E more effectively rather than having impaired absorption.
[Clinical and genetic analysis of a patient with Ataxia and vitamin E deficiency due to homozygous variant of TTPA gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
November 2024
Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Article Synopsis
Vitamin A, C and E levels in patients with Non-Alcoholic Fatty Liver Disease: An Indian Cohort Study.
Mymensingh Med J
October 2024
Dr Sukumar Mondithoka, Assistant Professor, Department of Medicine, AIIMS Bhopal, India; E-mail:
Article Synopsis
- - The study compared levels of vitamins A, C, and E in 50 patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and 50 healthy controls, measuring vitamin levels alongside parameters like bone mineral density, fat storage, insulin resistance, and inflammation.
- - Results showed no significant deficiencies in vitamins A or C; however, vitamin E was notably higher in the NAFLD group, with only one deficiency case, contrasting with other research findings.
- - No significant correlations emerged between vitamin levels and the other parameters measured, indicating a need for more research to clarify the relationships among these factors in the context of NAFLD, especially within the Asian Indian population.
[Comprehensive evaluation of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in obese patients based on efficacy and nutrition].
Zhonghua Wei Chang Wai Ke Za Zhi
September 2024
Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Article Synopsis
- * All surgeries were successful with a low complication rate (6.1%), and significant weight loss was observed at 3, 6, and 12 months post-surgery, including a total body weight loss (TWL) of 40.56% by the one-year mark.
- * The treatment demonstrated improvement in metabolic diseases, with reductions in body weight and BMI showing substantial statistical significance.
Association of variant vitamin statuses and tuberculosis development: a systematic review and meta-analysis.
Ann Med
December 2024
Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Article Synopsis
- * Analysis of 69 eligible studies revealed that vitamin A deficiency is significantly linked to tuberculosis, with potential benefits of vitamin A supplementation, while vitamin D deficiency was also identified as a key risk factor.
- * The findings highlight that individuals with tuberculosis often have lower levels of vitamins A and D, suggesting a need for more community-based interventions to explore these associations further.
Comprehensive Evaluation of Sporadic Late-Onset Cerebellar Ataxias: Clinical Presentation, Diagnostic Challenges, and Treatment Outcomes.
Cureus
June 2024
Department of Neurology, Mohammed Vl University Hospital, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Article Synopsis
- Sporadic late-onset cerebellar ataxias (SLOCA) are challenging to diagnose due to their diverse causes and symptom variations, as shown in a study of six male patients averaging 55 years old.
- All patients experienced gait and balance issues, while some also had sensory problems, and neurological exams revealed different types of cerebellar syndromes along with peripheral neuropathy symptoms.
- Although brain MRIs showed cerebellar atrophy in some, most lab results were normal, except for notable vitamin E deficiency and anti-Hu antibodies in two, leading to treatment with Vitamin E and highlighting the need for better understanding and management strategies for SLOCA.
Micronutrient deficiencies in inflammatory bowel disease: an incidence analysis.
Eur J Gastroenterol Hepatol
October 2024
Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville.
Article Synopsis
- - The study examines micronutrient deficiencies in patients with inflammatory bowel disease (IBD), focusing on copper and vitamins A, B9, E, and K, which can lead to serious complications like anemia and colorectal cancer.
- - A review of medical records for 611 hospitalized IBD patients revealed that 10.1% had micronutrient deficiencies, with particular rates of deficiency varying between those with Crohn's disease and ulcerative colitis.
- - The research highlights the need for better recognition and assessment of these deficiencies, as associated symptoms like anemia, muscle weakness, and fatigue are often neglected in IBD patients.
Fat-Soluble Vitamins A, D, E, and K: Review of the Literature and Points of Interest for the Clinician.
J Clin Med
June 2024
Servicio de Medicina Interna, Facultad de Medicina, Instituto de Investigación Sanitaria del Hospital San Carlos, Hospital Clínico San Carlos, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Article Synopsis
- * Certain populations, like newborns, pregnant women, and the elderly, are more susceptible to deficiencies, especially those with digestive or chronic health issues.
- * Symptoms of deficiencies can lead to specific health problems; treatment involves vitamin supplementation and addressing dietary or health-related causes.
Nutritional parameters following first episode of pediatric acute pancreatitis.
Clin Nutr ESPEN
October 2024
Department of Pediatrics, College of Medicine, University of Cincinnati, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, USA.
Article Synopsis
- * Out of 181 patients, most had mild AP, while a smaller percentage faced moderate or severe cases; results indicated stable BMI over 12 months, but significant deficiencies in Vitamin D, ferritin, and other nutrients were observed.
- * Notably, 13% of patients developed pre-diabetes or diabetes after the episode, and 24% experienced low albumin levels shortly after, indicating potential concerns for long-term nutritional health in this population.
Role of Antioxidant Vitamins in Oral Submucous Fibrosis: A Narrative Review.
Cureus
May 2024
Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Oral submucous fibrosis (OSMF) is a chronic inflammatory disease linked to malignant transformation, primarily caused by betel quid chewing and associated with oxidative stress from reactive oxygen species (ROS).
- Current treatments for OSMF have not been effective in curing the condition due to its complex origins, but research indicates that oxidative stress levels are elevated, with increased malonaldehyde (MDA) and decreased antioxidant vitamins like A, C, and E.
- Administering antioxidant vitamins may alleviate symptoms and help assess the clinical stage of OSMF, suggesting potential for more effective treatment strategies.
[Chylomicron retention disease caused by SAR1B gene variations in 2 cases and literatures review].
Zhonghua Er Ke Za Zhi
June 2024
Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.
To summarize the genotype and clinical characteristics of chylomicron retention disease (CMRD) caused by secretion associated Ras related GTPase 1B (SAR1B) gene variations. Clinical data and genetic testing results of 2 children with CMRD treated at Children's Hospital of Fudan University and Jiangxi Provincial Children's Hospital from May 2022 to July 2023 were summarized. To provide an overview of the clinical and genetic characteristics of CMRD caused by SAR1B gene variations, all of the literature was searched and reviewed from China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China VIP database, China Biology Medicine disc and PubMed database (up to January 2024) with "chylomicron retention disease" "Anderson disease" or "Anderson syndrome" as the search terms.
View Article and Find Full Text PDFVitamin E nomenclature. Is RRR-α-tocopherol the only vitamin E?
Free Radic Biol Med
August 2024
Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Tokyo, Japan. Electronic address:
Article Synopsis
- Vitamin E encompasses a group of compounds known as tocochromanols, which includes various tocopherols and tocotrienols.
- Recent proposals suggest limiting the term "vitamin E" to only RRR-α-tocopherol, prompting a debate about nomenclature within the scientific community.
- The authors argue that excluding other tocochromanols from the vitamin E category is premature, as more research is needed to fully understand their health benefits and mechanisms of action.
Current insights into equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy.
Vet J
June 2024
Center for Equine Health, School of Veterinary Medicine, University of California, Davis, CA, USA; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address:
Article Synopsis
- * There are no pre-death tests available for diagnosing eNAD/EDM; definitive diagnosis requires postmortem examination of the brain and spinal cord, while research is ongoing to find reliable antemortem indicators.
- * Prevention strategies include ensuring pregnant mares and foals have access to pasture and potentially supplementing their diets with high doses of vitamin E, but monitoring is necessary to avoid overdosing, which can lead to blood clotting issues.
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration.
Protein Cell
November 2024
Institute for Immunology and School of Basic Medicine, Tsinghua University, Beijing 100084, China.
Article Synopsis
- - SCARB2 deficiency is linked to neurodegenerative diseases like Gaucher and Parkinson's, as well as causing progressive myoclonus epilepsy (PME), which involves muscle spasms and movement issues.
- - Research on SCARB2-deficient mice shows that this deficiency leads to problems with fat absorption and vitamin E deficiency, due to changes in gut bacteria and bile acids impacting intestinal functions.
- - Treating these mice with FXR inhibitors or vitamin E supplements improved their movement issues and nerve function, suggesting that digestive health plays a crucial role in neurodegenerative conditions linked to SCARB2.
Equine neuroaxonal dystrophy/degenerative myeloencephalopathy in Gypsy Vanner horses.
J Vet Intern Med
May 2024
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA.
Article Synopsis
- eNAD/EDM is a neurodegenerative disease affecting young horses, particularly those deficient in vitamin E, and has not been observed in Gypsy Vanner horses until now.
- A study evaluated 26 Gypsy Vanners for clinical symptoms, vitamin E levels before and after supplementation, and confirmed the presence of eNAD/EDM in some horses through necropsy.
- Results showed a high percentage of low pre-supplementation vitamin E levels and only half achieved normal vitamin E levels after supplementation, suggesting a possible genetic predisposition in Gypsy Vanners and the need for careful vitamin E monitoring in young horses.
The Potential Role of Vitamin E and the Mechanism in the Prevention and Treatment of Inflammatory Bowel Disease.
Foods
March 2024
Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central South University of Forestry and Technology, Changsha 410004, China.
Article Synopsis
- Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is caused by various factors, with oxidative stress and inflammation being significant contributors.
- Vitamin E is highlighted for its strong antioxidant and anti-inflammatory properties that can help prevent and treat IBD, as supported by previous research.
- This paper discusses the sources and structure of vitamin E, its mechanisms in combating IBD, and emphasizes the effects of vitamin E deficiency in patients, suggesting its role in enhancing immunity and maintaining gut health.
Vitamin E: Not only a single stereoisomer.
Free Radic Biol Med
March 2024
BASF SE, Nutrition & Health Division, Ludwigshafen am Rhein, Germany.
Article Synopsis
- - Azzi and colleagues assert that only RRR-α-tocopherol should be considered as vitamin E for physiological purposes, claiming it’s the only form effective in treating vitamin E deficiency in humans (AVED).
- - They correctly point out that other tocopherols and tocotrienols lack vitamin E activity, but research shows that multiple 2R-forms of α-tocopherol also exhibit physiological activity, supported by how they are handled in the body.
- - The authors argue against limiting vitamin E to just RRR-α-tocopherol, demonstrating that AVED can be successfully treated with other forms, and they address safety concerns regarding the broader definition of vitamin E that is now widely accepted. *
Human Vitamin E deficiency, and what is and is not Vitamin E?
Free Radic Biol Med
March 2024
Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Ataxia with Vitamin E Deficiency: A Never to be Missed Treatable Ataxia.
Ann Indian Acad Neurol
September 2023
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Computed tomographic characteristics of confirmed and presumed noncutaneous pythiosis in 25 dogs.
Vet Radiol Ultrasound
March 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Article Synopsis
- Pythium insidiosum is a pathogen affecting dogs, leading to infections primarily in the skin and gastrointestinal tract; this study focuses on its CT characteristics in noncutaneous cases.
- The research involved 25 dogs, mostly with gastrointestinal infections, revealing common lesion features like specific wall thickening and enhancement patterns.
- The study highlights that while CT findings can be similar to tumors, pythiosis should be considered when diagnosing young dogs, indicating CT is useful for assessing this infection.
Genetic heterogeneity within a consanguineous family involving and genes.
J Neurogenet
March 2024
Molecular Neurobiology and Neuropathology Department, National Institute Mongi Ben Hamida of Neurology, Tunisia.
Article Synopsis
- Autosomal recessive cerebellar ataxias (ARCA) are a group of diverse neurodegenerative disorders that often manifest before adulthood, caused by different genetic mutations in affected individuals.
- The study reported on four Tunisian patients from a consanguineous family, two diagnosed with ataxia with vitamin E deficiency (AVED) and two with oculo-motor apraxia 2 (AOA2), highlighting clinical and genetic distinctions between their conditions.
- Genetic testing confirmed the diagnoses, revealing a common pathogenic variant and a new variant, emphasizing the complexities of genetic counseling in inbred populations due to increased occurrence of rare disorders.
Genetically Proven Ataxia With Vitamin E Deficiency With Predominant Cervicobrachial Dystonic Presentation: A Case Report From India.
J Mov Disord
April 2024
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Atypical retinopathy in ataxia with vitamin E deficiency: report of a sibship.
Neurogenetics
January 2024
Department of Ophthalmology, IHU FOReSIGHT, Hôpital Universitaire Pitié-Salpêtrière, Sorbonne Université, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
Article Synopsis
- A new form of retinopathy has been observed in patients with ataxia due to vitamin E deficiency (AVED), which differs from typical retinitis pigmentosa (RP).
- The case series involves two related patients who showed unique retinal patterns characterized by scattered, bright patches that are stable even with vitamin E treatment.
- Researchers suggest that these retinal changes may be due to halted progression of RP in AVED patients who received early vitamin E supplementation.