Drug utilization evaluation of pantoprazole in Kempegowda Institute of Medical Sciences (KIMS) hospital and research centre, India.

Objective: To evaluate the rational use of Pantoprazole by analyzing the appropriateness of prescription.

Methodology: This cross-sectional study was performed within four months in 150 patients hospitalized in Kempegowda Institute of Medical Sciences Hospital and Research Centre, India. Demographic data, type and doses of Pantoprazole, including risk factors, and other relevant clinical data were recorded.

Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer.

Tamoxifen is one of the most used drugs for breast cancer. This study aimed to investigate the effect of the Tamoxifen mechanism on the epithelial-mesenchymal transition (EMT) pathway among breast cancer patients due to its resistance to breast cancer cells. We selected the appropriate datasets from the GEO database using continuous and integrated bioinformatics analysis.

Exploring Community Pharmacist's Knowledge, Attitude, and Practice toward the Provision of Pharmaceutical Care. A Prospective Cross-sectional Study from Saudi Arabia.

Background: Pharmaceutical care (PC) is the new way of practicing the pharmacist's rule; practicing the PC will improve the quality of life of the patient by providing advices and counseling such as following up the patient after taking the medicines.

Objective: Evaluating the knowledge, attitude, practice, and perceived barriers of community pharmacists in Qassim, Saudi Arabia, toward the provision of PC.

Materials And Methods: A cross-sectional study consisting of a questionnaire was conducted to gather data from pharmacy professionals working in community pharmacies in Qassim region of Saudi Arabia between September 2019 and May 2020.

Pharmacodynamic and pharmacokinetic interaction of losartan with glimepiride-metformin combination in rats and rabbits.

Objectives: The presence of comorbidities such as cardiovascular disease, peripheral vascular disease, and chronic renal disease, or and the prevention of these ailments in diabetics, frequently demands multiple drug treatments, increasing the risk of drug-drug interactions (DDIs). The current study was focused on identifying possible DDIs on concomitant administration of losartan, a drug used to regulate hypertension along with a combination of glimepiride + metformin, widely used to treat diabetes mellitus. Possible pharmacodynamic and pharmacokinetic interactions were observed for, following single-dose as well as multiple-dose treatment protocols in normal and alloxan-induced diabetes in albino Wistar rats and rabbits.

Management of Drug-Drug Interactions among Critically Ill Patients with Chronic Kidney Disease: Impact of Clinical Pharmacist's Interventions.

Background And Objectives: Drug-drug interactions (DDIs) can create a burden on prescribers to preserve patient safety. This study aimed to identify common DDIs in critically ill patients with chronic kidney disease (CKD) and to evaluate clinical pharmacist's interventions in managing DDIs among these patients.

Methods: A prospective observational study was conducted from October 2018 to March 2019.

A clinical pharmacist-led integrated approach for evaluation of medication errors among medical intensive care unit patients.

Aim: Medication errors jeopardize the safety of critically ill patients. Using only one method for the detection of medication errors may not reflect an existing picture of patient safety accurately. Therefore, we designed a clinical pharmacist-led integrated approach to evaluate incidence rate, type, and severity of medication errors and preventable adverse drug events (ADEs) and to assess the impact of the implementation of interventions recommended by the clinical pharmacist.

Pharmaceutical Excipient Exposure in a Neonatal Intensive Care Unit.

Objective: To study the excipients exposure among neonates in a neonatal intensive care unit.

Method: Prospective observational study was conducted from January, 2017 to June, 2019. Details of administered drugs were collected from the hospital case files.

Phenolic compounds, saponins and alkaloids on cancer progression: emphasis on p53 expression and telomere length.

Telomere length is correlated with cell proliferation, and cancer cells are characterized by an uncontrolled cell cycle. Being apoptosis one of the checks and balances incorporated into cells cycle, due to its characteristics, cancer cells are able to overcome this process. In particular, the tumour suppressor protein p53 loss or inactivation can lead to activation of telomerase enzyme, which can make cells unable to detect DNA damages that spurs apoptosis.

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications.

The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp.

Thermosensitive liposomal gels loaded with antimicrobial agent for oral care in critically ill patients.

A novel thermosensitive gel loaded with meropenem (MP) liposomes was designed to improve retention in the oral cavity as a prophylactic measure to prevent ventilator-acquired pneumonia in critically ill patients. Meropenem liposomes were incorporated into poloxamer 407 gels and gamma irradiated. Mean size of liposome was 247 nm, polydispersity index < 0.

Identifying characteristics of drug-related problems in critically ill patients with decompensated liver cirrhosis.

Objectives: Characteristics of drug-related problems and related patient harm has not been evaluated in critically ill patients with decompensated cirrhosis. Our objectives were to identify characteristics and incidence rate of drug-related problems and related preventable harm in critically ill patients with decompensated liver cirrhosis.

Patients And Methods: A prospective observational study was conducted from February 2018 to January 2019 in 10-bed medical intensive care unit of a tertiary care hospital.

Evaluation of the effect of time dependent dosing on pharmacokinetic and pharmacodynamics of amlodipine in normotensive and hypertensive human subjects.

In clinical practice, circadian rhythms play a prominent role in pharmacokinetics and cell responses to therapy, hence necessitating in designing a defined protocol for drug administration. Clinical evidence for chronopharmacological behavior of cardiovascular active drugs in human subjects has been limited for amlodipine. Hence, the present study was undertaken to study the chronopharmacokinetic and chronopharmacodynamic phenomena of amlodipine and evaluate the effect of time of dosage in hypertensive subjects.

A study on knowledge and awareness about tuberculosis in senior school children in Bangalore, India.

Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), commonly affecting the lungs. All health care professionals including the pharmacists provide a valuable public health role in promoting community awareness of TB particularly in reducing stigma attached to TB.

Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves.

An increasing demand for natural additives has shifted the attention from synthetic to natural antioxidants and antifungal agents. This study was carried out to evaluate the antifungal and antioxidant activities of methanol, chloroform, and aqueous extracts of Annona squamosa Linn. leaves.

Anti-stress and nootropic activity of drugs affecting the renin-angiotensin system in rats based on indirect biochemical evidence.

Introduction: Various stress hormones are responsible for bringing out stress-related changes and are implicated in learning and memory processes. The extensive clinical experience of angiotensin receptor blockers (ARBs) and direct renin inhibitor as antihypertensive agents provides anecdotal evidence of improvements in cognition. The neurochemical basis underlying the anti-stress and nootropic effects are unclear.

Risk factors and management of diabetic nephropathy.

To determine the risk factors for nephropathy in diabetic patients and to study the management of diabetic nephropathy (DN), we conducted a hospital-based prospective study in the Internal Medicine department of our hospital on 60 patients with DN and 60 diabetic patients without DN. An odds ratio (OR) disclosed the following risk factors: Hypertension (OR = 2.06), family history of diabetes (OR = 1.

Liposomes as carriers of the lipid soluble antioxidant resveratrol: evaluation of amelioration of oxidative stress by additional antioxidant vitamin.

Aim: Resveratrol (RES) is a well-known antioxidant, yet in combination with other antioxidant vitamins, it was found to be more effective than any of these antioxidants alone. Present work aims to compare the antioxidant actions of resveratrol with and without vitamin C following delivery as liposomes tested using chemical and cellular antioxidative test systems.

Main Methods: Liposomes were prepared by the thin film hydration method and characterised for percent drug entrapment (PDE), Z-average mean size (nm), polydispersity index (PDI) and zeta potential.

Evaluation of enalapril affecting the renin-angiotensin system in normal and stress-induced rats based on urinary metabolites of amines and cortisol.

Introduction: The renin-angiotensin system is distributed centrally as well as peripherally, which works in association with SNS and HPA in stress. Angiotensin is considered one of the principal hormones for bringing out stress-related changes. To find the influence of enalapril on the neuromediator of CNS and periphery, the present work was carried out.

Prenatal exposure to anti-tubercular drugs and postnatal effect on growth, development and cognitive ability in rats.

The effect of prenatal exposure to antitubercular drugs in therapeutic and double therapeutic doses on postnatal developments was studied in albino rats of Wistar strain. Seven groups with six female rats each were taken for the study and were allowed to mate with male in the ratio of (2:1). The drugs isoniazid 27 and 54mg/kg b.

Illustration of anti-rheumatic mechanism of rheumavedic capsule.

The present study was taken up to illustrate the mechanism of anti-rheumatic activity of 'Rheumavedic capsule', a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced paw edema in rats. Analgesic mechanism is illustrated using Eddy's hot plate and acetic acid (0.

Evaluation of anti-ulcerogenic properties from the root of Flemingia strobilifera.

Purpose: To investigate the anti-ulcerogenic properties of the chloroform extract of Flemingia strobilifera root in rats.

Methods: Anti-ulcer effect was evaluated by water immersion induced ulcer in rats. Other anti-ulcer related activities of the extract such as the effects on free radicals and antimicrobial activity were also evaluated.

Biodegradable dental implants of ciprofloxacin beta-cyclodextrin inclusion complex in the treatment of periodontitis.

Dental implants of ciprofloxacin beta-cyclodextrin inclusion complex were formulated using poly (epsilon-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters, viz.

CLINICAL EFFICACY OF BIODEGRADABLE DENTAL IMPLANTS OF TINIDAZOLE IN PERIODONTITIS.

Dental implants of tinidazole were formulated using poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters viz.