Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.

Background: Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.

Objective: To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.

Design: Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.