7 results match your criteria: "Virginia Spine Research Institute[Affiliation]"
Allogeneic Disc Progenitor Cells Safely Increase Disc Volume and Improve Pain, Disability, and Quality of Life in Patients With Lumbar Disc Degeneration-Results of an FDA-Approved Biologic Therapy Randomized Clinical Trial.
Int J Spine Surg
July 2024
Semmes-Murphey Clinic and Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA
Background: Progenitor cells derived from intervertebral disc tissue demonstrated immunomodulatory and regenerative properties in preclinical studies. We report the safety and efficacy results of a US Food and Drug Administration-approved clinical trial of these cells for the treatment of symptomatic degenerative disc disease.
Methods: Sixty patients with symptomatic single-level lumbar degenerative disc disease (mean age 37.
Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy.
Spine J
February 2021
Mesoblast Inc., 12912 Hill Country Blvd, Building F, Suite 230, Bee Cave, TX 78738, USA.
Background Context Purpose: Evaluate the safety and efficacy of a single intradiscal injection of STRO-3+ adult allogeneic mesenchymal precursor cells (MPCs) combined with hyaluronic acid (HA) in subjects with chronic low back pain (CLBP) associated with degenerative disc disease (DDD) through 36-month follow-up.
Study Design/setting: A multicenter, randomized, controlled study conducted at 13 clinical sites (12 in the United States and 1 in Australia).
Subject Sample: A total of 100 subjects with chronic low back pain associated with moderate DDD (modified Pfirrmann score of 3-6) at one level from L1 to S1 for at least 6 months and failing 3 months of conservative treatment, including physical therapy were randomized in a 3:3:2:2 ratio to receive 6 million MPCs with HA, 18 million MPCs with HA, HA vehicle control, or saline control (placebo) treatment.
Chronic Spinal Pain: Pathophysiology, Diagnosis, and Treatment.
Pain Res Manag
August 2019
Pain Department, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China.
Cervical disc degeneration and neck pain.
J Pain Res
November 2018
Interventional Spine and Musculoskeletal Care, Virginia iSpine Physicians, PC Virginia Spine Research Institute, Inc Richmond, VA, USA.
Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reactions, and is susceptible to pain that can be provoked by disc stimulation or distention, and can be eliminated by block.
View Article and Find Full Text PDFDiagnostic Nihilism Toward Low Back Pain: What Once Was Accepted, Should No Longer Be.
Pain Med
August 2015
President, Medical Director, Director, Interventional Spine Care Fellowship, Virginia iSpine Physicians, PC, President, Director of Research, Virginia Spine Research Institute, Inc.
Corticosteroid choice for epidural injections.
PM R
June 2013
Virginia iSpine Physicians, PC, and Virginia Spine Research Institute, Inc, Richmond, VA, USA.
Multivariable analyses of the relationships between age, gender, and body mass index and the source of chronic low back pain.
Pain Med
April 2012
Virginia Spine Research Institute, Inc, and Virginia iSpine Physicians, PC, Richmond, Virginia 23235, USA.
Objective: To examine the combined relationships between age, gender, and body mass index (BMI) and the specific source of chronic low back pain.
Design: Retrospective chart review.
Setting: University spine center.