Youth, caregiver, and clinician perspectives of youth Patient-Reported Outcome Measures (PROMs) in a psychological training clinic: lessons from early adopters.

This study examines the applicability and utility of youth Measurement-Based Care (MBC) in a community-based psychological training clinic. Considering the complexity of youth compared to adult MBC, there is an increasing need to expand the evidence base. This study investigated how doctoral students in clinical psychology managed the selection and usage of Patient Rated Outcome Measures (PROMs) for youth and their parents.

Winners and Losers From Climate Change: An Analysis of Climate Thresholds for Tree Growth and Survival for Roughly 150 Species Across the Contiguous United States.

Changes in temperature and precipitation are already influencing US forests and that will continue in the future even as we mitigate climate change. Using spatiotemporally matched data for mean annual temperature (MAT) and mean annual precipitation (MAP), we used simulated annealing to estimate critical thresholds for changes in the growth and survival of roughly 150 tree species (153 spp. for growth, 159 spp.

Identifiability investigation of within-host models of acute virus infection.

Uncertainty in parameter estimates from fitting within-host models to empirical data limits the model's ability to uncover mechanisms of infection, disease progression, and to guide pharmaceutical interventions. Understanding the effect of model structure and data availability on model predictions is important for informing model development and experimental design. To address sources of uncertainty in parameter estimation, we used four mathematical models of influenza A infection with increased degrees of biological realism.

Highly Active Oligoethylene Glycol Pleuromutilins via Systematic Linker Synthesis/One-Pot Attachment and a Microscale Solubility Method.

The semisynthetic derivatization of natural products is crucial for their continued development as antibiotics. While commercial pleuromutilin derivatives depend on amines for solubility, we demonstrate the high activity and solubility of oligoethylene glycol-substituted pleuromutilins achieved via a one-pot deprotection/attachment approach using thiolates protected as thioesters. The bifunctional linker synthesis is versatile and can be broadly applied to other chemistries.

A higher-order quadratic NLS equation on the half-line.

The well-posedness of the initial-boundary value problem for higher-order quadratic nonlinear Schrödinger equations on the half-line is studied by utilizing the Fokas solution formula for the corresponding linear problem. Using this formula, linear estimates are derived in Bourgain spaces for initial data in spatial Sobolev spaces on the half-line and boundary data in temporal Sobolev spaces suggested by the time regularity of the linear initial value problem. Then, the needed bilinear estimates are derived and used for showing that the iteration map defined via the Fokas solution formula is a contraction in appropriate solution spaces.

Quantitative Liver Fat Assessment by Handheld Point-of-Care Ultrasound: A Technical Implementation and Pilot Study in Adults.

Objectives: To implement, examine the feasibility of, and evaluate the performance of quantitative ultrasound (QUS) with a handheld point-of-care US (POCUS) device for assessing liver fat in adults.

Materials And Methods: This prospective IRB-approved, HIPAA-compliant pilot study enrolled adults with overweight or obesity. Participants underwent chemical-shift-encoded magnetic resonance imaging to estimate proton density fat fraction (PDFF) and, within 1 mo, QUS with a POCUS device by expert sonographers and novice operators (no prior US scanning experience).

The physiological and molecular responses of potato tuberization to projected future elevated temperatures.

Potato (Solanum tuberosum L.) is one of the most important food crops globally and is especially vulnerable to heat stress. However, substantial knowledge gaps remain in our understanding of the developmental mechanisms associated with tuber responses to heat stress.

Companion animal foster caregiving: a scoping review exploring animal and caregiver welfare, barriers to caregiver recruitment and retention, and best practices for foster care programs in animal shelters.

Each year, millions of animals enter animal shelters across the United States and are met with a variety of potential stressors that can negatively impact their experience, including noise, confinement, and social isolation. Foster care, a unique form of human-animal interaction, is increasingly understood to be an effective tool for improving welfare by allowing animals to escape the stressors of the shelter, providing an environment that allows for greater social interaction, and offering opportunities for improved health and behavior. This review includes 42 published articles, reports, master's theses, and doctoral dissertations that have previously evaluated companion animal foster care programs.

Associations among PTSD symptoms, fear of emotion, and couple communication difficulties: A between-person dyadic analysis.

This study investigated between-person associations among PTSD symptoms, fear of emotion, and perceived couple communication difficulties in a dyadic context among 64 trauma-exposed, mixed gender community couples (N = 128 individuals) using the Actor-Partner Interdependence Mediation Model. Individuals with higher PTSD symptoms endorsed greater fear of their emotions (β = .72; β = .

Toward rapid silica analysis of CPDM samples: Deposition of recovered dust and analysis by FTIR.

The ongoing resurgence of severe Coal Workers' Pneumoconiosis in the US has been linked to overexposure to respirable crystalline silica (RCS, which is predominantly present as quartz and regulated as such). Capabilities that enable more frequent RCS monitoring are highly sought. Recent developments include field-based quartz analysis of traditional filter samples-collected on polyvinyl chloride (PVC) filters-using portable Fourier Transform Infrared spectroscopy (FTIR).

Screening novel antiviral compounds to treat Clostridioides difficile infections.

Clostridioides difficile is a major cause of nosocomial infections, often associated with individuals who have gut dysbiosis from previous antibiotic therapies. C. difficile infections (CDI) have a high recurrence rate and impose significant financial and mortality burdens on the healthcare system.

Longitudinal Associations Between Psychological Resilience and Cognitive Function:Evidence from the U.S. Health and Retirement Study.

Objective: Reductions in psychological resilience and declining cognition are common among older adults. Understanding the longitudinal association between them could be beneficial for interventions that focus on age-related cognitive and psychological health. In this study, we evaluated the longitudinal associations between cognition and psychological resilience over time in a nationally representative sample of US older adults.

Semiparametric change points detection using single index spatial random effects model in environmental epidemiology study.

Environmental health studies are of great interest in research to evaluate the mortality-temperature relationship by adjusting spatially correlated random effects as well as identifying significant change points in temperature. However, this relationship is often not expressed using parametric models, which makes identifying change points an even more challenging problem. This paper proposes a unified semiparametric approach to simultaneously identify the nonlinear mortality-temperature relationship and detect spatially-dependent change points.

Intrinsic and environmental drivers of pairwise cohesion in wild Canis social groups.

Animals within social groups respond to costs and benefits of sociality by adjusting the proportion of time they spend in close proximity to other individuals in the group (cohesion). Variation in cohesion between individuals, in turn, shapes important group-level processes such as subgroup formation and fission-fusion dynamics. Although critical to animal sociality, a comprehensive understanding of the factors influencing cohesion remains a gap in our knowledge of cooperative behavior in animals.

Classification algorithms trained on simple (symmetric) lifting data perform poorly in predicting hand loads during complex (free-dynamic) lifting tasks.

The performance of machine learning (ML) algorithms is dependent on which dataset it has been trained on. While ML algorithms are increasingly used for lift risk assessment, many algorithms are often trained and tested on controlled simulation datasets, lacking the diversity of the lifting conditions. Consequently, concerns arise regarding their applicability in real-world scenarios characterized by substantial variations in lifting scenarios and postures.

Pediatric Constraint-Induced Movement Therapy: Current Practices and Implementation Barriers.

Hemiplegic Cerebral Palsy (CP) is the most common pediatric motor disability, characterized by unilateral motor weakness. Pediatric Constraint-Induced Movement Therapy (pCIMT) improves affected extremity function but faces variable clinical integration. This study assessed U.

Optimal Dielectric Boundary for Binding Free Energy Estimates in the Implicit Solvent.

Accuracy of binding free energy calculations utilizing implicit solvent models is critically affected by parameters of the underlying dielectric boundary, specifically, the atomic and water probe radii. Here, a multidimensional optimization pipeline is used to find optimal atomic radii, specifically for binding calculations in the implicit solvent. To reduce overfitting, the optimization target includes separate, weighted contributions from both binding and hydration free energies.

An updated and expanded characterization of the biological sciences academic job market.

Introduction: In the biological sciences, many areas of uncertainty exist regarding the factors that contribute to success within the faculty job market. Earlier work from our group reported that beyond certain thresholds, academic and career metrics like the number of publications, fellowships or career transition awards, and years of experience did not separate applicants who received job offers from those who did not. Questions still exist regarding how academic and professional achievements influence job offers and if candidate demographics differentially influence outcomes.

Effects of Synthetic CpG Oligodeoxynucleotide K3 on Immune Response, Behavior, and Physiology in Male Layer Chicks ().

Unmethylated cytosine-phosphate-guanine (CpG) motifs are often found in bacteria and viruses, but are rare in mammals. In mammals, CpG oligodeoxynucleotides (CpG ODN) stimulate the innate immune system via toll-like receptor 9 (TLR9). However, TLR9 is absent in birds; instead, TLR21 serves as the receptor for CpG ODN.

Enhancing resistance to in yellow-feathered broilers: a study of a strain of as probiotic feed additives.

strains are potentially rich sources of probiotics that could help avoid infections. In order to evaluate their efficacy in bolstering resistance to infection among chicks. In this study, and commercial probiotics were administered via the water supply at a dosage of 1×10 CFU per chicken from days 1 to 7 to establish a protective system for the chicks.

Synergistic potential of lopinavir and azole combinational therapy against clinically important Aspergillus species.

Aspergillus fumigatus is a widely distributed pathogen responsible for severe infections, particularly in immunocompromised individuals. Triazoles are the primary treatments options for Aspergillus infections; however, the emergence of acquired resistance to this antifungal class is becoming a growing concern. In this study, we investigated the potential of the antiviral drug, lopinavir (LPV) to restore the susceptibility of A.