426 results match your criteria: "Virginia (JW); and The George Washington University Medical Faculty Associates[Affiliation]"

Objective Design: In June of 2024, Becton Dickinson experienced a blood culture bottle shortage for their BACTEC system, forcing health systems to reduce usage or risk exhausting their supply. Virginia Commonwealth University Health System (VCUHS) in Richmond, VA decided that it was necessary to implement austerity measures to preserve the blood culture bottle supply.

Setting: VCUHS includes a main campus in Richmond, VA as well as two affiliate hospitals in South Hill, VA (Community Memorial Hospital (CMH)) and Tappahannock Hospital in Tappahannock, VA.

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Objective: To determine whether endometriosis typology, namely ovarian endometriomas (OE), deep infiltrating endometriosis (DIE), or superficial endometriosis (SE), correlates with fertility history.

Design: Prospective cohort.

Setting: One of fourteen surgical centers in Salt Lake City, Utah (n = 5) or San Francisco, California (n = 9).

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The Anti-AGEing and RAGEing Potential of Isothiocyanates.

Molecules

December 2024

Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.

Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis of precursors known as glucosinolates. ITCs have been studied extensively both in vivo and in vitro to define their therapeutic potential for the treatment of chronic health conditions. Therapeutically, they have shown an intrinsic ability to inhibit oxidative and inflammatory phenotypes to support enhanced health.

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Background:  Nephrotoxin exposure may worsen kidney injury and impair kidney recovery if continued in patients with acute kidney injury (AKI).

Objectives:  This study aimed to determine if tiered implementation of a clinical decision support system (CDSS) would reduce nephrotoxin use in cardiac surgery patients with AKI.

Methods:  We assessed patients admitted to the cardiac surgery intensive care unit at a tertiary care center from January 2020 to December 2021, and August 2022 to September 2023.

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Objectives: There is a burgeoning discrepancy between the procedural competency of graduating diagnostic radiology residents and the needs of our patient population. The causes of this mismatch and opportunities for improvement are explored by the APDR Procedural Competency of Graduating DR Residents Task Force.

Materials And Methods: The APDR convened a task force consisting of diverse broad stakeholder viewpoints, drawing from organized radiology, academic and private practices.

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Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact immune activation or suppression within the TME. This study investigated candidate T-cell populations and their differential infiltration within different tumor types as estimated from mRNA co-expression levels of the corresponding cellular markers.

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Cerebellar Involvement in Attacks of Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorder.

Neurol Neuroimmunol Neuroinflamm

January 2025

From the Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology (A.D., L.C., J.J.-W.C., B.G.W., S.A.B., S.J.P., E.P.F.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurosciences (A.D.), Biomedicine, and Movement Sciences, University of Verona, Italy; Department of Radiology (K.N.K.), Mayo Clinic; Department of Ophthalmology (J.J.-W.C.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology (D.M.W., C.V.-S.), Mayo Clinic, Scottsdale, AZ; Department of Neurology (B.G.W.), University of Virginia, Charlottesville; Department of Neurology (A.S.L.-C.), Mayo Clinic College of Medicine, Jacksonville, FL; Neurology Unit (E.S.), University Hospital of Sassari, Italy; and Department of Laboratory Medicine and Pathology (S.J.P., E.P.F.), Mayo Clinic College of Medicine, Rochester, MN.

Article Synopsis
  • The study analyzes how often and in what way the cerebellum is affected during attacks of aquaporin-4-IgG positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), which isn't fully covered by current diagnostic standards.
  • Out of 432 AQP4+NMOSD patients, 17 (4%) showed cerebellar attacks with severe neurological symptoms, including high disability scores.
  • MRI results indicated that most cerebellar lesions were found in the cerebellar peduncles and dentate nucleus, with many persisting beyond six months, suggesting that understanding these patterns is important for refining future diagnostic criteria for AQP4+NMOSD.
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Jaundice and Prolonged Hyperbilirubinemia in a 33-day-old Infant.

Pediatr Rev

December 2024

Division of Pediatric Hospital Medicine, Department of Pediatrics, West Virginia University, J.W. Ruby Memorial Hospital, Morgantown, WV.

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Article Synopsis
  • * AAR-RRA's task force studied how academic radiologists contribute beyond just high clinical volumes and RVU-generating work, highlighting the importance of these additional roles.
  • * Their findings are shared in a two-part report, with the first part addressing the current situation in radiology and the second part outlining future strategies for striking a better balance between clinical work and non-RVU activities.
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State-of-the-Art Deep Learning CT Reconstruction Algorithms in Abdominal Imaging.

Radiographics

December 2024

From the Department of Radiology, University of Washington School of Medicine, Seattle, Wash (A.M.); Department of Radiology, Mayo Clinic, Rochester, Minn (L.Y.); Department of Radiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY (J.W.R.); Departments of Radiation Oncology (S.K.) and Abdominal Imaging (M.A.S., J.J.I.R., V.K.W., K.M.E., C.T.J.), The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1473, Houston, TX 77030-4009; Department of Radiology, Texas Children's Hospital, Houston, Tex (A.M.R.C.); and Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea (J.M.L.).

Article Synopsis
  • The development of deep neural networks has led to deep learning reconstruction (DLR) CT algorithms, enhancing image creation processes by integrating deep learning at various stages of imaging.
  • DLR techniques effectively reduce image noise from lower radiation doses while maintaining image quality and diagnostic performance compared to traditional methods like filtered backprojection (FBP) and iterative reconstruction (IR).
  • Clinical evidence supports the use of DLR algorithms for abdominal imaging across multiple tasks, showcasing their benefits, current limitations, and future prospects in CT imaging.
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In health insurance, "moral hazard" describes the concept that coverage without an out-of-pocket cost to consumers could result in health care utilization beyond economically efficient levels. In response, payers in the United States (US) have designed pharmaceutical benefit plans with significant cost exposure (e.g.

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Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson's disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amygdala and hippocampus are not well established. We analyzed 3D T1-weighted brain MRI and clinical data from 2525 individuals with PD and 1326 controls from 22 global sources in the ENIGMA-PD consortium.

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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.

N Engl J Med

November 2024

From Baylor University Medical Center, Dallas (M.P.); Imperial College, London (M.P.); RHJ Department of Veterans Affairs, Health System and Medical University of South Carolina, Charleston (M.R.Z., S.E.L.); the Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville (C.M.K.); Flourish Research, Boca Raton, FL (S.J.B.); the Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland (V.M.); the Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (J.G.); Eli Lilly, Indianapolis (G.J.W., Y.O., M.C.B., K.C.H., M.M.); and the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.).

Background: Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, causes considerable weight loss, but data are lacking with respect to its effects on cardiovascular outcomes.

Methods: In this international, double-blind, randomized, placebo-controlled trial, we randomly assigned, in a 1:1 ratio, 731 patients with heart failure, an ejection fraction of at least 50%, and a body-mass index (the weight in kilograms divided by the square of the height in meters) of at least 30 to receive tirzepatide (up to 15 mg subcutaneously once per week) or placebo for at least 52 weeks.

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Unlabelled: Antigen-based rapid diagnostic tests (Ag-RDTs) provide timely results, are simple to use, and are less expensive than molecular assays. Recent studies suggest that antigen-based testing aligns with virus culture-based results (a proxy of contagiousness at the peak viral phase of illness); however, the performance of Ag-RDTs for newer SARS-CoV-2 variants is unclear. In this study, we (i) assessed the performance of Ag-RDTs and diagnostic antibodies to detect a range of SARS-CoV-2 variants and (ii) determined whether Ag-RDT results correlated with culture positivity.

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Introduction: Multicancer detection tests (MCDs) are blood-based tests designed to detect multiple cancer types. It is currently unclear whether these cancer screening tests improve mortality. To understand awareness of MCDs among providers and patients, as well as explore how they perceive the benefits, harms, and acceptability of MCDs, we have undertaken a focus group study in primary care physicians (PCPs) and laypersons to explore knowledge, attitudes, and expectations of cancer screening using MCDs.

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Purpose: To characterize the early postoperative complications following outpatient tibial tubercle osteotomy (TTO) to determine its safety in this setting.

Methods: Patients undergoing TTO by a single surgeon between July 2017 and August 2022 for patellar instability or patellofemoral chondromalacia and achieving a minimum of 3 months of clinical and radiographic follow-up were evaluated for inclusion. Although an inclusion criterion was a minimum follow-up of 3 months, if evidence of a healed osteotomy was observed sooner, final follow-up was accepted at 2 months.

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Article Synopsis
  • An error grid is a tool that helps compare glucose levels measured by devices to see if they are correct and to identify any risks.
  • Experts created a new error grid called the DTS Error Grid that works for both blood glucose monitors (BGMs) and continuous glucose monitors (CGMs), organizing accuracy into five risk zones.
  • The results showed that the DTS Error Grid provides a clearer picture of how accurate these devices are and includes a separate matrix to evaluate how well CGMs track glucose trends over time.
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Article Synopsis
  • Diagnosing Alzheimer's disease is tough for doctors, which can lead to delays in getting the right care for patients.
  • Blood tests that check for signs of Alzheimer's could help doctors find the disease earlier and treat it better, but there are still some big challenges to overcome.
  • A special group of leaders in Alzheimer's research is working on solutions, like creating better guidelines, training healthcare workers, and making sure patients understand their test results.
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Article Synopsis
  • Most pandemic viruses have a protective covering and enter cells through a specific method that involves helper proteins.
  • Researchers found that a protein called TRPM7 is very important for these viruses to infect cells, as it helps create the right conditions inside the cell for the virus to fuse and enter.
  • The study suggests that targeting TRPM7 could lead to new medicines that could prevent many types of these viruses from infecting cells.
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Article Synopsis
  • Blood-based biomarkers (BBMs) are new tests that help doctors check for Alzheimer's disease in a simpler and cheaper way than older methods like brain scans or spinal fluid tests.! -
  • A special group called the Global CEO Initiative on Alzheimer's Disease is suggesting two ways to use these BBMs: one for initial testing and another to confirm more serious cases.! -
  • Using BBMs can make it easier for doctors to diagnose Alzheimer's, which means that patients can start getting needed treatments faster.!
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The emergence of the United States Food and Drug Administration (FDA)-approved amyloid-targeting therapies for Alzheimer's disease challenges clinicians and healthcare providers with a transformative landscape. Effectively communicating the risks, benefits, burdens, costs, and available support associated with these novel disease-modifying treatments to patients, families, and other healthcare providers is essential but complex. In response, the Alzheimer's Association's Clinical Meaningfulness Workgroup has proposed language surrounding treatment eligibility, benefits, amyloid-related imaging abnormalities (ARIA), apolipoprotein E (APOE) genotyping, and treatment costs, serving as a resource to healthcare professionals in navigating discussions with patients and their families.

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Analysis of Gender Discrepancies in Leadership Roles and Recognition Awards in the Child Neurology Society.

Neurology

September 2024

From the Department of Neurology (J.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Providence Health and Services (A.L.C.), OR; Department of Pediatrics (G.Y.G.), Emory University School of Medicine, Children's Healthcare of Atlanta, GA; Department of Neurology (B.R.A.), School of Medicine, Washington University in St Louis and St Louis Children's Hospital, MO; Department of Neurology (L.J.), University of Virginia, Charlottesville; Division of Pediatric Neurology (S.J.), Department of Pediatrics, University of Michigan, Ann Arbor; Department of Neurology (J.B.S.), University of California, San Francisco; Child Neurology Society (M.T.), Minneapolis, MN; LSU Health Sciences Center and Children's Hospital New Orleans (A.H.T.), LA; Department of Neurology (P.L.P.), Harvard Medical School, Boston, MA; Department of Physical Medicine and Rehabilitation (J.K.S.), Harvard Medical School; Spaulding Rehabilitation Hospital (J.K.S.); Massachusetts General Hospital (J.K.S.); Brigham and Women's Hospital (J.K.S.), Boston, MA; Pittsford, NY (J.W.M.); and Division of Child Neurology (Y.K.), Departments of Pediatrics and Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.

Article Synopsis
  • The study investigates gender representation in leadership positions and award recipients within the Child Neurology Society (CNS) over a 50-year period, from 1972 to 2023.
  • Despite women making up the majority of child neurology trainees since 2007, they hold only 29% of board positions and 26% of post-training awards, indicating a persistent gender gap.
  • While the number of women in nonpresidential roles has increased, only 13% of CNS presidents have been women, highlighting significant underrepresentation in top leadership positions.
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Safety and behavior of implantable electronic devices during cremation.

Heart Rhythm

August 2024

Harvard Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Background: The current standard of practice for cremating patients with cardiac implantable electronic devices (CIEDs) is surgical explantation before cremation to mitigate the risk of device explosion. This surgery may conflict with patient or family beliefs, whereas cremation of CIEDs may create occupational hazards.

Objective: This study sought to establish an ex vivo model for screening CIED behavior during cremation.

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A survey on the real-world clinical utilization of a traditional acupuncture in Republic of Korea: Sa-am acupuncture.

J Integr Med

September 2024

Department of Anatomy and Acupoint, College of Korean Medicine, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea. Electronic address:

Objective: This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors (KMDs) think about Sa-am acupuncture.

Methods: We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their practice. The study comprehensively investigated issues related to clinical application of Sa-am acupuncture, needling techniques used during treatment, training methods, and directions for its future improvement.

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Fluorescence in situ hybridization (FISH) using break-apart probes is recommended for identifying high-grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2). Unbalanced MYC break-apart patterns, in which the red or green signal is lost, are commonly reported as an equivocal result by clinical laboratories. In a cohort of 297 HGBCL-DH-BCL2, 13% of tumors had unbalanced MYC break-apart patterns with loss of red (LR; 2%) or loss of green (LG; 11%) signal.

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