426 results match your criteria: "Virginia (JW); and The George Washington University Medical Faculty Associates[Affiliation]"
Antimicrob Steward Healthc Epidemiol
January 2025
Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Objective Design: In June of 2024, Becton Dickinson experienced a blood culture bottle shortage for their BACTEC system, forcing health systems to reduce usage or risk exhausting their supply. Virginia Commonwealth University Health System (VCUHS) in Richmond, VA decided that it was necessary to implement austerity measures to preserve the blood culture bottle supply.
Setting: VCUHS includes a main campus in Richmond, VA as well as two affiliate hospitals in South Hill, VA (Community Memorial Hospital (CMH)) and Tappahannock Hospital in Tappahannock, VA.
F S Rep
December 2024
Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah.
Objective: To determine whether endometriosis typology, namely ovarian endometriomas (OE), deep infiltrating endometriosis (DIE), or superficial endometriosis (SE), correlates with fertility history.
Design: Prospective cohort.
Setting: One of fourteen surgical centers in Salt Lake City, Utah (n = 5) or San Francisco, California (n = 9).
Molecules
December 2024
Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis of precursors known as glucosinolates. ITCs have been studied extensively both in vivo and in vitro to define their therapeutic potential for the treatment of chronic health conditions. Therapeutically, they have shown an intrinsic ability to inhibit oxidative and inflammatory phenotypes to support enhanced health.
View Article and Find Full Text PDFAppl Clin Inform
January 2025
Institute for Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Background: Nephrotoxin exposure may worsen kidney injury and impair kidney recovery if continued in patients with acute kidney injury (AKI).
Objectives: This study aimed to determine if tiered implementation of a clinical decision support system (CDSS) would reduce nephrotoxin use in cardiac surgery patients with AKI.
Methods: We assessed patients admitted to the cardiac surgery intensive care unit at a tertiary care center from January 2020 to December 2021, and August 2022 to September 2023.
Acad Radiol
December 2024
Department of Radiology, Penn Medicine, University of Pennsylvania, Philadelphia, PA, USA (M.S.).
Objectives: There is a burgeoning discrepancy between the procedural competency of graduating diagnostic radiology residents and the needs of our patient population. The causes of this mismatch and opportunities for improvement are explored by the APDR Procedural Competency of Graduating DR Residents Task Force.
Materials And Methods: The APDR convened a task force consisting of diverse broad stakeholder viewpoints, drawing from organized radiology, academic and private practices.
Cells
December 2024
Departments of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact immune activation or suppression within the TME. This study investigated candidate T-cell populations and their differential infiltration within different tumor types as estimated from mRNA co-expression levels of the corresponding cellular markers.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
January 2025
From the Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology (A.D., L.C., J.J.-W.C., B.G.W., S.A.B., S.J.P., E.P.F.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurosciences (A.D.), Biomedicine, and Movement Sciences, University of Verona, Italy; Department of Radiology (K.N.K.), Mayo Clinic; Department of Ophthalmology (J.J.-W.C.), Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology (D.M.W., C.V.-S.), Mayo Clinic, Scottsdale, AZ; Department of Neurology (B.G.W.), University of Virginia, Charlottesville; Department of Neurology (A.S.L.-C.), Mayo Clinic College of Medicine, Jacksonville, FL; Neurology Unit (E.S.), University Hospital of Sassari, Italy; and Department of Laboratory Medicine and Pathology (S.J.P., E.P.F.), Mayo Clinic College of Medicine, Rochester, MN.
Pediatr Rev
December 2024
Division of Pediatric Hospital Medicine, Department of Pediatrics, West Virginia University, J.W. Ruby Memorial Hospital, Morgantown, WV.
Acad Radiol
November 2024
Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (G.J.W.).
Radiographics
December 2024
From the Department of Radiology, University of Washington School of Medicine, Seattle, Wash (A.M.); Department of Radiology, Mayo Clinic, Rochester, Minn (L.Y.); Department of Radiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY (J.W.R.); Departments of Radiation Oncology (S.K.) and Abdominal Imaging (M.A.S., J.J.I.R., V.K.W., K.M.E., C.T.J.), The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1473, Houston, TX 77030-4009; Department of Radiology, Texas Children's Hospital, Houston, Tex (A.M.R.C.); and Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea (J.M.L.).
J Mark Access Health Policy
December 2024
Center for Value Based Insurance Design (V-BID), University of Michigan, Ann Arbor, MI 48109, USA;
In health insurance, "moral hazard" describes the concept that coverage without an out-of-pocket cost to consumers could result in health care utilization beyond economically efficient levels. In response, payers in the United States (US) have designed pharmaceutical benefit plans with significant cost exposure (e.g.
View Article and Find Full Text PDFNPJ Parkinsons Dis
November 2024
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson's disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amygdala and hippocampus are not well established. We analyzed 3D T1-weighted brain MRI and clinical data from 2525 individuals with PD and 1326 controls from 22 global sources in the ENIGMA-PD consortium.
View Article and Find Full Text PDFN Engl J Med
November 2024
From Baylor University Medical Center, Dallas (M.P.); Imperial College, London (M.P.); RHJ Department of Veterans Affairs, Health System and Medical University of South Carolina, Charleston (M.R.Z., S.E.L.); the Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville (C.M.K.); Flourish Research, Boca Raton, FL (S.J.B.); the Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland (V.M.); the Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China (J.G.); Eli Lilly, Indianapolis (G.J.W., Y.O., M.C.B., K.C.H., M.M.); and the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.).
Background: Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, causes considerable weight loss, but data are lacking with respect to its effects on cardiovascular outcomes.
Methods: In this international, double-blind, randomized, placebo-controlled trial, we randomly assigned, in a 1:1 ratio, 731 patients with heart failure, an ejection fraction of at least 50%, and a body-mass index (the weight in kilograms divided by the square of the height in meters) of at least 30 to receive tirzepatide (up to 15 mg subcutaneously once per week) or placebo for at least 52 weeks.
mBio
December 2024
Microbiology and Immunology Department, Biological Defense Research Directorate, Naval Medical Research Command, Fort Detrick, Maryland, USA.
Unlabelled: Antigen-based rapid diagnostic tests (Ag-RDTs) provide timely results, are simple to use, and are less expensive than molecular assays. Recent studies suggest that antigen-based testing aligns with virus culture-based results (a proxy of contagiousness at the peak viral phase of illness); however, the performance of Ag-RDTs for newer SARS-CoV-2 variants is unclear. In this study, we (i) assessed the performance of Ag-RDTs and diagnostic antibodies to detect a range of SARS-CoV-2 variants and (ii) determined whether Ag-RDT results correlated with culture positivity.
View Article and Find Full Text PDFCancer Med
November 2024
Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA.
Introduction: Multicancer detection tests (MCDs) are blood-based tests designed to detect multiple cancer types. It is currently unclear whether these cancer screening tests improve mortality. To understand awareness of MCDs among providers and patients, as well as explore how they perceive the benefits, harms, and acceptability of MCDs, we have undertaken a focus group study in primary care physicians (PCPs) and laypersons to explore knowledge, attitudes, and expectations of cancer screening using MCDs.
View Article and Find Full Text PDFArthrosc Sports Med Rehabil
August 2024
Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia, U.S.A.
Purpose: To characterize the early postoperative complications following outpatient tibial tubercle osteotomy (TTO) to determine its safety in this setting.
Methods: Patients undergoing TTO by a single surgeon between July 2017 and August 2022 for patellar instability or patellofemoral chondromalacia and achieving a minimum of 3 months of clinical and radiographic follow-up were evaluated for inclusion. Although an inclusion criterion was a minimum follow-up of 3 months, if evidence of a healed osteotomy was observed sooner, final follow-up was accepted at 2 months.
J Diabetes Sci Technol
November 2024
University of California San Francisco, San Francisco, CA, USA.
Alzheimers Dement
November 2024
Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Nat Commun
October 2024
Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Alzheimers Dement
November 2024
Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, USA.
Alzheimers Dement
November 2024
Alzheimer's Association, Chicago, Illinois, USA.
The emergence of the United States Food and Drug Administration (FDA)-approved amyloid-targeting therapies for Alzheimer's disease challenges clinicians and healthcare providers with a transformative landscape. Effectively communicating the risks, benefits, burdens, costs, and available support associated with these novel disease-modifying treatments to patients, families, and other healthcare providers is essential but complex. In response, the Alzheimer's Association's Clinical Meaningfulness Workgroup has proposed language surrounding treatment eligibility, benefits, amyloid-related imaging abnormalities (ARIA), apolipoprotein E (APOE) genotyping, and treatment costs, serving as a resource to healthcare professionals in navigating discussions with patients and their families.
View Article and Find Full Text PDFNeurology
September 2024
From the Department of Neurology (J.M.M.), Wake Forest University School of Medicine, Winston-Salem, NC; Providence Health and Services (A.L.C.), OR; Department of Pediatrics (G.Y.G.), Emory University School of Medicine, Children's Healthcare of Atlanta, GA; Department of Neurology (B.R.A.), School of Medicine, Washington University in St Louis and St Louis Children's Hospital, MO; Department of Neurology (L.J.), University of Virginia, Charlottesville; Division of Pediatric Neurology (S.J.), Department of Pediatrics, University of Michigan, Ann Arbor; Department of Neurology (J.B.S.), University of California, San Francisco; Child Neurology Society (M.T.), Minneapolis, MN; LSU Health Sciences Center and Children's Hospital New Orleans (A.H.T.), LA; Department of Neurology (P.L.P.), Harvard Medical School, Boston, MA; Department of Physical Medicine and Rehabilitation (J.K.S.), Harvard Medical School; Spaulding Rehabilitation Hospital (J.K.S.); Massachusetts General Hospital (J.K.S.); Brigham and Women's Hospital (J.K.S.), Boston, MA; Pittsford, NY (J.W.M.); and Division of Child Neurology (Y.K.), Departments of Pediatrics and Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.
Heart Rhythm
August 2024
Harvard Thorndike Electrophysiology Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Background: The current standard of practice for cremating patients with cardiac implantable electronic devices (CIEDs) is surgical explantation before cremation to mitigate the risk of device explosion. This surgery may conflict with patient or family beliefs, whereas cremation of CIEDs may create occupational hazards.
Objective: This study sought to establish an ex vivo model for screening CIED behavior during cremation.
J Integr Med
September 2024
Department of Anatomy and Acupoint, College of Korean Medicine, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea. Electronic address:
Objective: This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors (KMDs) think about Sa-am acupuncture.
Methods: We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their practice. The study comprehensively investigated issues related to clinical application of Sa-am acupuncture, needling techniques used during treatment, training methods, and directions for its future improvement.
Blood
October 2024
Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada.
Fluorescence in situ hybridization (FISH) using break-apart probes is recommended for identifying high-grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2). Unbalanced MYC break-apart patterns, in which the red or green signal is lost, are commonly reported as an equivocal result by clinical laboratories. In a cohort of 297 HGBCL-DH-BCL2, 13% of tumors had unbalanced MYC break-apart patterns with loss of red (LR; 2%) or loss of green (LG; 11%) signal.
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