Prognostic Value of Separate Extramural Vascular Invasion Reporting in Operative Samples of Rectal Cancer: Single-Institutional Experience.

Background/objectives: Vascular invasion, especially extramural vascular invasion (EMVI), has emerged as a prognostic parameter for rectal cancer (RC) in recent years. Prediction of recurrence and metastasis development poses a significant challenge for oncologists, who need markers for prediction of adverse outcome. The aim of this study was to examine the prognostic significance of pathohistologically detected EMVI in untreated rectal cancer and its implications in separate reporting.

Luminescence Thermometry with Eu-Doped YMoO: Comparison of Performance of Intensity Ratio and Machine Learning Temperature Read-Outs.

Accurate temperature measurement is critical across various scientific and industrial applications, necessitating advancements in thermometry techniques. This study explores luminescence thermometry, specifically utilizing machine learning methodologies to enhance temperature sensitivity and accuracy. We investigate the performance of principal component analysis (PCA) on the Eu-doped YMoO luminescent probe, contrasting it with the traditional luminescence intensity ratio (LIR) method.

Cobalt and Tungsten Extraction from Diamond Core Drilling Crowns by Aqua Regia Leaching.

In this work, a hydrometallurgical process for the recycling of diamond core drilling crowns by means of aqua regia leaching and subsequent alkali leaching was investigated. This investigation continues a previous study in which nitric acid was used for the acid leaching phase. In the current study, higher tungsten recovery was achieved, reaching 98.

Cationic waste hemp fibers-based membrane: Case study of anionic pollutants removal through environmentally friendly processes.

In this study, waste hemp fibers were transformed into cationically modified lignocellulosic adsorbent through a three-step process. First, a delignification/defibrillation pretreatment was performed, followed by quaternization of fibers using the synthesized ionic liquid chlorocholine chloride-urea (CCC-U). Pressure-assisted cross-linking of modified fibres, using a citric acid, produced new membrane (CCC-UHM).

Chlorine containing tetrahydropyrimidines: Synthesis, characterization, anticancer activity and mechanism of action.

The aim of the presented research was to explore anticancer potential of eleven newly synthesized tetrahydropyrimidine derivatives. The compounds were synthesized via Biginelli multicomponent one-pot reaction using different derivatives of vanillin, ethyl 4-chloroacetoacetate and (N-methyl)urea. The cytotoxic effects of the compounds were examined on three human malignant cell lines (HeLa, K562, and MCF7), and normal lung fibroblasts MRC-5.

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

New Pd(II)-pincer type complexes as potential antitumor drugs: synthesis, nucleophilic substitution reactions, DNA/HSA interaction, molecular docking study and cytotoxic activity.

Two new complexes of Pd(II), [Pd(L1)Cl]Cl (Pd1) and [Pd(L2)Cl]Cl (Pd2), (where L1 = ,-bis(5-methylthiazol-2-yl)pyridine-2,6-dicarboxamide and L2 = ,-di(benzo[]thiazol-2-yl)pyridine-2.6-dicarboxamide) were synthesized. Characterization of the complexes was performed using elemental analysis, IR, H NMR spectroscopy and MALDI-TOF mass spectrometry.

Development of a novel computational technique to create DNA and cell geometrical models for Geant4-DNA.

Background: This study aimed to develop a novel human cell geometry for the Geant4-DNA simulation toolkit that explicitly incorporates all 23 chromosome pairs of the human cell. This approach contrasts with the existing, default human cell, geometrical model, which utilizes a continuous Hilbert curve.

Methods: A Python-based tool named "complexDNA" was developed to facilitate the design of both simple and complex DNA geometries.

Enhancing Compressive Strength of Cement by Indigenous Individual and Co-Culture Bacteria.

Using a Taguchi experimental design, this research focuses on utilizing indigenous bacteria from the Danube River to enhance the self-healing capabilities and structural integrity of cementitious materials. and were used as individual bacterium or in co-culture, with a concentration of 8 logs CFU, while the humidity variation involved testing wet and wet-dry conditions. Additionally, artificial neural network (ANN) modeling of the compressive strength of cement samples results in improvements in compressive strength, particularly under wet-dry conditions.

Expression of , , , , , and in Relation to Left Ventricular Remodeling in Patients Six Months after the First Myocardial Infarction: A Prospective Study.

After myocardial infarction (MI), adverse left ventricular (LV) remodeling may occur. This is followed by LV hypertrophy and eventually heart failure. The remodeling process is complex and goes through multiple phases.

Circulatory Indicators of Lipid Peroxidation, the Driver of Ferroptosis, Reflect Differences between Relapsing-Remitting and Progressive Multiple Sclerosis.

Ferroptosis, a lipid peroxidation- and iron-mediated type of regulated cell death, relates to both neuroinflammation, which is common in relapsing-remitting multiple sclerosis (RRMS), and neurodegeneration, which is prevalent in progressive (P)MS. Currently, findings related to the molecular markers proposed in this paper in patients are scarce. We analyzed circulatory molecular indicators of the main ferroptosis-related processes, comprising lipid peroxidation (malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and hexanoyl-lysine adduct (HEL)), glutathione-related antioxidant defense (total glutathione (reduced (GSH) and oxidized (GSSG)) and glutathione peroxidase 4 (GPX4)), and iron metabolism (iron, transferrin and ferritin) to estimate their contributions to the clinical manifestation of MS and differences between RRMS and PMS disease course.

Nanosized Eu-Doped NaYSiO Oxyapatite Phosphor: A Comprehensive Insight into Its Hydrothermal Synthesis and Structural, Morphological, Electronic, and Optical Properties.

Detailed analysis covered the optical and structural properties of Eu-doped NaYSiO oxyapatite phosphors, which were obtained via hydrothermal synthesis. X-ray diffraction patterns of NaYSiO:xEu (x = 0, 1, 5, 7, 10 mol% Eu) samples proved a single-phase hexagonal structure ( (176) space group). Differential thermal analysis showed an exothermic peak at 995 °C attributed to the amorphous to crystalline transformation of NaYSiO.

Tuneable Red and Blue Emission of Bi-Co-Doped SrF:Eu Nanophosphors for LEDs in Agricultural Applications.

Tunable blue/red dual-emitting Eu-doped, Bi-sensitized SrF phosphors were synthesized utilizing a solvothermal-microwave method. All phosphors have cubic structure (- (225) space group) and well-distinct sphere-like particles with a size of ~20 nm, as examined by X-ray diffraction and transmission electron microscopy. The diffuse reflectance spectra reveal a redshift of the absorption band in the UV region as the Bi concentration in SrF: Eu phosphor increases.

Antimicrobial Activity of Amino-Modified Cellulose Nanofibrils Decorated with Silver Nanoparticles.

Silver nanoparticles (Ag NPs) conjugated with amino-functionalized cellulose nanofibrils (NH-CNFs) were in situ-prepared by reducing silver ions with free amino groups from NH-CNFs. The spectroscopy and transmission electron microscopy measurements confirmed the presence of non-agglomerated nanometer-in-size Ag NPs within micrometer-large NH-CNFs of high (20 wt.-%) content.

Sol-Gel Derived Alumina Particles for the Reinforcement of Copper Films on Brass Substrates.

The aim of this study is to provide tailored alumina particles suitable for reinforcing the metal matrix film. The sol-gel method was chosen to prepare particles of submicron size and to control crystal structure by calcination. In this study, copper-based metal matrix composite (MMC) films are developed on brass substrates with different electrodeposition times and alumina concentrations.

Thermal Quenching Mechanism of Mn in NaSiF, NaKSiF, and KSiF Phosphors: Insights from the First-Principles Analysis.

This study aims to identify the key factors governing the thermal quenching of Mn ion luminescence in fluoride-based phosphor materials used as red emitters in modern-day phosphor-converted LED devices. Here, we employ first-principles calculations for Mn-doped NaSiF, NaKSiF, and KSiF hosts to explore how host properties and local coordination environments influence thermal quenching behavior. The ΔSCF method was used to model the geometric structures of the MnA (ground) and E, T (excited) states and the energies of the optical transitions between these states.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

First-Principles Linear Combination of Atomic Orbitals Calculations of KSiF Crystal: Structural, Electronic, Elastic, Vibrational and Dielectric Properties.

The results of first-principles calculations of the structural, electronic, elastic, vibrational, dielectric and optical properties, as well as the Raman and infrared (IR) spectra, of potassium hexafluorosilicate (KSiF; KSF) crystal are discussed. KSF doped with manganese atoms (KSF:Mn) is known for its ability to function as a phosphor in white LED applications due to the efficient red emission from Mn⁴⁺ activator ions. The simulations were performed using the CRYSTAL23 computer code within the linear combination of atomic orbitals (LCAO) approximation of the density functional theory (DFT).

Seaweed as a Valuable and Sustainable Resource for Food Packaging Materials.

Plastic food packaging causes massive pollution in the environment via resource extraction, gas emissions, and the enduring plastic waste accumulation. Hence, it is of crucial importance to discover sustainable alternatives in order to protect ecosystems and conserve precious resources. Recently, seaweed has been emerging as a promising sustainable solution to plastic pollution.

Tyramine Derivatives as Versatile Pharmacophores With Potent Biological Properties: Sex Hormone-Binding Globulin Inhibition, Colon Cancer Antimigration, and Antimicrobial Activity.

Guided by the idea that the presence of a heterocyclic aromatic core and tyramine moiety, under the umbrella of a single molecular scaffold could bring interesting biological properties, herein we present synthesis, characterization, with two crystal structures reported, and biological evaluation of some tyramine derivates. Cytotoxic and antimigratory potential was addressed by using a colorectal cancer cell line as a model system. Although possessing no cytotoxic effects, two compounds have shown strong antimigratory potential in low doses, with no effect on healthy MRC-5 cells.

Dual-activity nanozyme as an oxygen pump to alleviate tumor hypoxia and enhance photodynamic/ NIR-II photothermal therapy for sniping oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region, and its treatment is limited by hypoxia and inadequate oxygen supply. Continuous oxygen delivery combined with photodynamic therapy (PDT) is the key to addressing this issue. Here, a dual-enzyme activity sea urchin-like Au@Pt-Ce6-HN-1 nanoplatform was designed to serve as an "oxygen pump" to alleviate tumor hypoxia for synergistic photodynamic/photothermal therapy (PTT).

A novel Co/Zn-ferrite molecularly imprinted polymer-based electrochemical assay for sensing of gallic acid in plant extracts, wine, and herbal supplement.

In this study, a new molecularly imprinted polymer (MIP)-based sensor platform was developed for the electrochemical determination of gallic acid (GAL) in plant extracts, wine, and herbal supplements. Gallic acid is known for its natural antioxidant properties, which play an important role in preventing cell deterioration that can lead to various diseases. In addition, gallic acid has therapeutic potential due to its anticancer, antiinflammatory, antimicrobial, and neuroprotective properties.