A Therapeutic Approach of Chitosan-loaded p-Coumaric Acid Nanoparticles to Alleviate Diabetic Nephropathy in Wister Rats.

Objective: This study evaluated the renoprotective effects of p-Coumaric acid nanoparticles (PCNPs) in nephropathic rats.

Methods: Six groups of male Albino Wistar rats were randomly assigned. Group 1 was the control, while Group 2 received 45 mg/kg of streptozotocin (STZ) to induce diabetic nephropathy.

Diagnostic Accuracy of Optic Nerve Sheath Diameter Using Ultrasonography for Raised Intracranial Pressure in Pediatric Patients - A Systematic Review and Meta-Analysis.

Purpose: Detecting increased intracranial pressure early in pediatric patients is essential, as early initiation of therapy prevents morbidity and mortality. The objective of this study was to determine the diagnostic accuracy of the optic nerve sheath diameter (ONSD) measured via ultrasound for the prediction of increased intracranial pressure.

Methods: Four databases, namely, PubMed, EMBASE, Scopus, and CINAHL, were searched for this systematic review and meta-analysis.

Glycosylated Hemoglobin as an Independent Prognostic Marker in COVID-19 Patients With Diabetes Mellitus.

Objective The main objective of this study is to analyze the severity of coronavirus disease 2019 (COVID-19) among patients with diabetes mellitus using glycosylated hemoglobin (HbA1c) as a prognostic marker in predicting the outcome among these individuals. Methods This was a retrospective, observational study conducted in a tertiary care center during the first and second waves of COVID-19 in Salem, Tamil Nadu, for a period of one year (September 2020-September 2021). Numerous variables, including socio-demographic data, vitals, laboratory and radiological investigations, and end variables like mortality and morbidity due to COVID-19, were studied.

Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract.

Magnesium deficiency enhances oxidative stress which contributes to early development of cataract formation, and also the progression in type 2 diabetes mellitus patients remains unclear. The present study was designed to evaluate the serum levels of magnesium, oxidative stress marker and antioxidant status and to find out if there is any association between them in the pathogenesis of diabetic cataract compared with non-diabetic senile cataract, diabetes without cataract and normal healthy subjects. This comparative study includes 90 type 2 diabetes mellitus patients with cataract, 90 non-diabetic senile cataract patients, 90 type 2 diabetes mellitus without cataract and 90 normal healthy individual subjects without cataract in the age group between 40 and 75 years of both genders.

Whole-mol-ecule disorder of the Schiff base compound 4-chloro--(4-nitro-benzyl-idene)aniline: crystal structure and Hirshfeld surface analysis.

In the crystal of the title Schiff base compound, CHClNO, [CNBA; systematic name: ()--(4-chloro-phen-yl)-1-(4-nitro-phen-yl)methanimine], the CNBA mol-ecule shows whole-mol-ecule disorder (occupancy ratio 0.65:0.35), with the disorder components related by a twofold rotation about the shorter axis of the mol-ecule.

Crystal structure and Hirshfeld surface analysis of poly[[di-μ-glycine-lithium] perchlorate].

In the title salt, {[Li(CHNO)]ClO} , the Li cation is coordinated by four carboxyl-ate oxygen atoms of the glycine mol-ecules with a distorted tetra-hedral geometry. The glycine exists in a zwitterionic form with protonated amino and deprotonated carboxyl-ate groups. In the crystalline state, the title salt is primarily stabilized by inter-molecular N-H⋯O and C-H⋯O inter-actions which inter-connect various units.

Distressing cutaneous lesion among bipolar affective disorder patients on lithium therapy: A retrospective cross-sectional study.

Aim: To assess the incidence of cutaneous lesion in bipolar affective disorder (BPAD) patients on lithium therapy. To evaluate the relationship between duration of lithium therapy, dosage of lithium, serum lithium level, and cutaneous lesions. To assess whether reduction/stoppage of dose of lithium has any change in the course of cutaneous side effects.

Lingual thyroid-conservative management or surgery? A case report.

A Lingual thyroid is relatively rare. Of all ectopic thyroids 90 % are found to be Lingual thyroids. We report a case of 32 year old female who presented to us with history of mass on back of the tongue with history of dysphagia.

Laparoscopic removal of lithopaedion.

Lithopaedion means a calcified Dead foetus and it is usually extrauterine. We report a case of 32 year old female who presented to us with right iliac fossa mass. On diagnostic laparoscopy, it was found to be Lithopaedion and the same was removed in toto through laparoscopic approach.

Cock's Peculiar Tumour.

A 28 year old female presented to us with cock's peculiar tumour. This tumour is one of the complications of sebaceous cyst. Patient underwent excision for the same.