Repurposing Linezolid in Conjunction with Histone Deacetylase Inhibitor Access in the Realm of Glioblastoma Therapies.

Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.

Endohedral boron-doped scandium clusters BSc ( = 2-3, = 3-13): triangular - linear rearrangement of the B dopant.

A theoretical investigation, employing density functional theory with the PBE functional and the Def2-TZVP basis set, comprehensively explores the geometric and electronic structures and properties of the boron doped scandium clusters BSc with = 2-3 and = 3-13. Introduction of B atoms significantly enhances the stability of the resulting clusters with respect to the initial counterparts. As the number of B atoms increases, the stability of the doped clusters improves, following the order: BSc > BSc > BSc > Sc.

Reclassification of Salisediminibacterium haloalkalitolerans Sultanpuram et al. 2015 as a Later Heterotypic Synonym of Salisediminibacterium halotolerans Jiang et al. 2012.

In the present study, the taxonomic position of Salisediminibacterium haloalkalitolerans was evaluated by determining the 16S rRNA gene sequence similarity, genome relatedness, and phylogenetic analyses. The 16S rRNA gene sequences extracted from the genomes of Salisediminibacterium haloalkalitolerans 10nlg and Salisediminibacterium halotolerans DSM 26530 showed 100% similarity, supporting their classification as the same species. The average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between S.

Optimizing the properties of In-N dual-doped SnO films: incorporation of nitrogen into the SnO lattice at the optimal content direct current sputtering.

Direct current magnetron sputtering was employed to fabricate In-N dual-doped SnO films, with varying concentrations of N in a mixed sputtering gas of N and argon (Ar). The quantity of -substituted O elements in the SnO lattice was confirmed through energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). A comprehensive investigation of properties of the In-N dual-doped SnO films was conducted using various techniques, including X-ray diffraction analysis, field-emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), ultraviolet absorption spectroscopy, Hall effect measurements, and current-voltage (-) characteristic assessments.

Epidemiology and Genotype Dynamics of Dengue in Hospitalized Patients in Northern Vietnam Between 2020 and 2022.

Background: Arboviruses, including Dengue (DENV), Zika, and chikungunya, cause recurrent outbreaks of varying intensity in tropical countries. This study aimed to investigate other arboviruses, including Zika and chikungunya, in patients clinically suspected of Dengue and to characterize the circulating Dengue serotypes and genotypes in Northern Vietnam from 2020 to 2022. To date, information on this topic in the region has been limited.

Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster.

The electronic and optical properties of a composite created by introducing a magnetite cluster into NaA zeolite have been investigated in this work using DFT calculations. The results obtained indicate that the electronic and optical properties of the composite are enhanced because of the cluster. However, the properties exhibited by the cluster outside the zeolite differ from those it presents when it is part of the composite.

Petroleum ether extract of induces senescence and inhibits invasion in breast cancer MDA-MB-231 cells.

Unlabelled: Kunth H.B et Kunth is an herbal plant employed customarily for the treatment of numerous maladies, notably cancers. Here in this research, we studied the effects of () petroleum ether extract (EM-PE) on the highly aggressive breast cancer cell line MDA-MB-231.

Global distribution and sustainable management of Asian corn borer (ACB), (Lepidoptera: Crambidae): recent advancement and future prospects.

The Asian corn borer (ACB), (Guenée, 1854), is a serious pest of several crops, particularly a destructive pest of maize and other cereals throughout most of Asia, including China, the Philippines, Indonesia, Malaysia, Thailand, Sri Lanka, India, Bangladesh, Japan, Korea, Vietnam, Laos, Myanmar, Afghanistan, Pakistan and Cambodia. It has long been known as a pest in South-east Asia and has invaded other parts of Asia, Solomon Islands, parts of Africa and certain regions of Australia and Russia. Consequently, worldwide efforts have been increased to ensure new control strategies for management.

Gender and Race Differences in Rates of PTSD Service Connection: Results From a Nationally Representative Panel of OEF/OIF/OND Veterans.

Background: Department of Veterans Affairs disability benefits for post-traumatic stress disorder (PTSD), also known as "service connection," have been shown to reduce homelessness and poverty, increase mental health engagement, and improve clinical outcomes. However, gender and race disparities in PTSD service connection have been described in Vietnam and post-Vietnam era Veterans.

Methods: Post-traumatic stress disorder service connection outcomes were assessed in a nationally representative, randomly selected, gender-stratified, prospective panel of 960 Veterans who served during Operations Enduring Freedom, Iraqi Freedom, and New Dawn.

Deer antler velvet (Cervus elaphus sibiricus) promotes fracture healing via partial BMP2-Smad mediated osteoblast differentiation.

Unlabelled: BACKGROUND CERVUS ELAPHUS SIBIRICUS: (CES) has been traditionally used in Korean clinics to promote fracture healing based on its function of tonifying the kidneys and strengthening bones. However, experimental data supporting its efficacy are still insufficient. The aim of this study investigated the bone-union properties of CES in a femoral fracture animal model and its corresponding molecular mechanisms.

High prevalence of soil-transmitted helminths among primary students in Ha Giang, Vietnam: A descriptive cross-sectional study.

Despite improvements in environmental sanitation and healthcare, the infection rate of soil-transmitted helminths (STHs) remains high in low socioeconomic regions of developing countries including Vietnam. This study aimed to determine the prevalence and intensity of STH infections among primary school children in Meo Vac, Ha Giang: a poor mountainous province in Vietnam. A descriptive cross-sectional study was conducted from October to November 2023, involving 400 participants.

Factors protecting against progression of myopia in school students exposed to societal change in Vietnam: a 3-year cohort study.

Objectives: To elucidate the incidence of myopia, progression of refractive error, axial length (AL) elongation and factors associated with myopia in secondary school students in Vietnam.

Design: Prospective cohort study.

Settings: Hue Healthy Adolescent Cohort Study, Hue City, Vietnam.

nT4X and nT4M: Novel Time Non-reversible Mixture Amino Acid Substitution Models.

One of the most important and difficult challenges in the research of molecular evolution is modeling the process of amino acid substitutions. Although single-matrix models, such as the LG model, are popular, their capability to properly capture the heterogeneity of the substitution process across sites is still questioned. Several mixture models with multiple matrices have been introduced and shown to offer advantages over single-matrix models.

Atmospheric pressure spatial atomic layer deposition of p-type CuO thin films from copper(II) acetylacetonate and ozone for UV detection.

Cupric oxide (CuO) is a promising p-type semiconducting oxide used in many critical fields, such as energy conversion and storage, and gas sensors, which is attributed to its unique optoelectrical properties and cost-effectiveness. This work successfully deposited amorphous, pinhole-free, ultrathin CuO films using atmospheric pressure spatial atomic layer deposition (SALD) with copper(II) acetylacetonate and ozone as precursors. The growth rate increased from 0.

Mountainous millipedes in Vietnam. III. Two new dragon millipedes from limestone mountains in northern Vietnam (Polydesmida, Paradoxosomatidae, ), with an identification key to Vietnamese species.

Two new species of the dragon millipede genus Cook & Loomis, 1924 are described from mountainous areas in northern Vietnam, namely and The COI barcodes are provided for these species, and an identification key is presented to all Vietnamese species.

Photocatalytic degradation performance of a chitosan/ZnO-FeO nanocomposite over cationic and anionic dyes under visible-light irradiation.

The sonochemical synthesis of a chitosan-ZnO/FeO nanocomposite yielded a highly porous structure and large surface area for enhancing the photocatalytic degradation of cationic (rhodamine B, RhB) and anionic (methyl orange, MO) dyes in aqueous solution. Chitosan-ZnO/FeO demonstrated a significant enhancement in photodegradation efficiency 99.49% for MO ( = 5.

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021.

Background: The burden of mental disorders (MD) in the Western Pacific Region (WPR) remains a critical public health concern, with substantial variations across demographics and countries.

Aim: To analyze the burden of MD in the WPR from 1990 to 2021, along with associated risk factors, to reveal changing trends and emerging challenges.

Methods: We used data from the Global Burden of Disease 2021, analyzing prevalence, incidence, and disability-adjusted life years (DALYs) of MD from 1990 to 2021.

Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems.

Dihydromyricetin (DHM or DMY) is a flavonoid derived from natural sources with a range of confirmed biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. DHM is recognized for its high biosafety, making it a promising subject for further research.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

Coinfection of and porcine circovirus type 3 is linked to reproductive failure in pig farms.

Background And Aim: Reproductive disorders in swine herds pose significant challenges to pig breeding due to both infectious and non-infectious factors. In large-scale pig farming, coinfections are increasingly common, affecting sow health and herd productivity. This study aimed to determine occurrence and coinfection patterns of s and porcine circovirus type 3 in Vietnamese pig farms and to evaluate their association with reproductive disorders and clinical signs in affected herds.

FDG-PET-based brain network analysis: a brief review of metabolic connectivity.

Background: Over the past decades, the analysis metabolic connectivity patterns has received significant attention in exploring the underlying mechanism of human behaviors, and the neural underpinnings of brain neurological disorders. Brain network can be considered a powerful tool and play an important role in the analysis and understanding of brain metabolic patterns. With the advantages and emergence of metabolic-based network analysis, this study aims to systematically review how brain properties, under various conditions, can be studied using Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) images and graph theory, as well as applications of this approach.

Endocuff Vision-Assisted Colonoscopy Significantly Improves Adenoma Detection In A Shorter Withdrawal Time Compared With Standard Colonoscopy: A Randomized Controlled Trial.

Introduction: Although several studies in Western countries have shown that Endocuff Vision-assisted colonoscopy (EC) can improve the colorectal adenoma detection rate (ADR), such evidence in Asia is still scarce. This study aimed to evaluate the performance of EC in detecting colorectal adenomas in Vietnamese patients.

Methods: This was a randomized controlled trial conducted at a tertiary hospital in Vietnam.

Contamination of retail market meat with extended-spectrum beta-lactamase genes in Vietnam.

The contamination of retail meat with antibiotic-resistant bacteria poses a substantial public health risk because of the potential spread of these bacteria within communities. The contamination of retail meat with extended-spectrum beta-lactamase (ESBL)-producing bacteria was investigated in four cities in Vietnam using real-time PCR, employing ESBL marker genes. This method provides a more comprehensive assessment of ESBL-producing bacterial contamination in meat samples than culture-based methods because it directly detects resistance genes from the extracted sample DNA.

Agingassociated challenges to persons living with HIV/AIDS in Vietnam: integrated perspectives from multiple stakeholders.

This study examined the aging-associated health and care needs among the HIV population in Vietnam, integrating perspectives from healthcare professionals, PLWH, and their caregivers. Qualitative data were collected through five focus group interviews involving ten PLWH, nine caregivers, and eight healthcare providers in Hanoi, Vietnam, in March 2023. Thematic analyses uncovered recurring patterns and themes across the three participant groups.