Enhancement of Transdermal Drug Delivery: Integrating Microneedles with Biodegradable Microparticles.

This investigation aimed to enhance transdermal methotrexate delivery through human skin by employing Dr. Pen microneedles and poly(d,l-lactide--glycolide) acid microparticles formulated from eight polymer grades (Expansorb DLG 95-4A, DLG 75-5A, DLG 50-2A, DLG 50-5A, DLG 50-8A, DLG 50-6P, DLG 50-7P, and DLL 10-15A). A comprehensive characterization of the microparticles was performed, encompassing various parameters such as size, charge, morphology, microencapsulation efficiency, yield, release kinetics, and chemical composition.

Sulphonyl thiourea compounds containing pyrimidine as dual inhibitors of I, II, IX, and XII carbonic anhydrases and cancer cell lines: synthesis, characterization and studies.

Some novel sulphonyl thiourea derivatives (7a-m) containing 4,6-diarylpyrimidine rings were designed and synthesized using a one-pot procedure. These compounds exhibited remarkable dual inhibitory activity against human carbonic anhydrase CA I, CA II, CA IX, and XII isoenzymes and some cancer cell lines. Among them, some thioureas had significantly more potent inhibitory activities in the order of 7l > 7c > 7f (against the CA I isoform), 7f > 7b > 7c (against the CA II isoform), 7c > 7g > 7a > 7b (against the CA IX isoform), and 7d > 7c > 7g > 7f (against the CA XII isoform).

Digital analysis of the relationship between maximum bite force and 3-dimensional arrangement of mandibular first molars.

Background: Bite force is one of the important factors that determine the chewing efficiency of molars. This study aimed to investigate the relationship of the maximum bite force (MBF) to the 3-dimensional (3D) arrangement of the first mandibular molars in Angle's class I healthy adults using a digital protocol.

Material And Methods: Subjects were 33 adults (16 males and 17 females) aged 18-25, with Angle's class I occlusions and healthy dentitions.

Country of origin and prices of systemic antibiotics in Vietnam: a multicentre retrospective study.

Background: Local production of antibiotics is essential for improving access to treatment of clinical infection and avoiding vulnerability to expensive drug imports.

Objectives: To describe the country of origin and cost of antibiotics in Vietnam.

Methods: This was an observational study.

Efficiency of carbon dioxide capture with metal substitutions in the MIL-88A metal-organic framework.

Carbon dioxide capture is a vital approach for mitigating air pollution and global warming. In this context, metal-organic frameworks are promising candidates. Particularly, MIL-88A (M), where the metal nodes (M) are connected to fumarate linkers in its structure, has demonstrated significant potential for CO capture.

GLAC-Unet: Global-Local Active Contour Loss with an Efficient U-Shaped Architecture for Multiclass Medical Image Segmentation.

The field of medical image segmentation powered by deep learning has recently received substantial attention, with a significant focus on developing novel architectures and designing effective loss functions. Traditional loss functions, such as Dice loss and Cross-Entropy loss, predominantly rely on global metrics to compare predictions with labels. However, these global measures often struggle to address challenges such as occlusion and nonuni-form intensity.

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score.

Background And Objectives: Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis. This study aimed to evaluate the incremental prognostic utility of C-reactive protein (CRP) in conjunction with the InterTAK prognosis score for stratifying long-term mortality in Takotsubo syndrome.

The diagnostic accuracy of umbilical cord procalcitonin in predicting early-onset neonatal infection.

Introduction: To determine the threshold of umbilical cord blood procalcitonin for early-onset neonatal infection diagnosis.

Method: This prospective study was conducted on 126 neonates in the neonatal care unit of Hue University of Medicine and Pharmacy Hospital, Vietnam, from June 01, 2023 to August 31, 2024. All neonates showed signs at birth or risk factors for early-onset infection (EOI) and were divided into two groups: EOI group and non-EOI group.

Factors associated with quality of life of chronic spontaneous urticaria patients in a Vietnamese population.

Objective: Chronic spontaneous urticaria (CSU) is a challenging condition that significantly impacts the affected patients. This study aimed to evaluate the quality of life (QoL) among patients with CSU in Vietnam and identify factors associated with QoL.

Methods: A cross-sectional study was conducted at the Vietnam National Dermatology and Venereology Hospital from June 2023 to March 2024.

Evaluation of Genetic Diversity of Black Soybean [ (L.) Merr] by Using RAPD and ISSR Markers.

<b>Background and Objective:</b> Black soybeans [<i>Glycine max</i> (L.) Merr] are among the important crops, but the cultivated resources are normally low-yielding, susceptible to diseases and low profit. Therefore, it is necessary to evaluate the genetic diversity of black soybean germplasms for breeding programs.

Nutrition literacy in Vietnamese pregnant women: a cross-sectional study.

Inadequate nutrition intake during pregnancy elevates the risk of adverse health outcomes during pregnancy, with potential long-term repercussions for both mother and child, extending to subsequent generations. Current initiatives to improve individual dietary habits emphasize promoting nutrition literacy (NL), which encompasses the ability to access, comprehend, and use basic nutrition information and services necessary for making appropriate nutrition decisions. However, there were limited data on the NL of pregnant women in Vietnam.

Comparison of Patient-Specific Plates and Pre-Bent Plates for Preserving Condylar Position in Mandible Reconstruction.

Objectives: To compare the efficacy of patient-specific 3-dimensional (3D)-printed plates (PSP) and pre-bent universal reconstruction plates (PBP) in preserving the 3D position of the mandibular condyle and total operation time during mandibular reconstruction with a fibula-free flap.

Materials And Methods: This retrospective study included 18 patients who underwent mandibular reconstruction using fibular free flaps. Both groups utilized virtual surgical planning (VSP) and 3D-printed surgical guides.

Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing.

Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS/ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability.

Psychological ownership and knowledge sharing: Key psychological drivers of sustainable tourist behavior.

As the green transformation sweeps across industries in the digital age, tourism stakeholders face a pressing need to utilize online platforms and digital influencers for sustainability messaging. Drawing on the Motivation-Opportunity-Ability framework, this study investigates the influence of green ownership psychology and green knowledge sharing on tourists' repatronage intentions. It focuses on the mediating role of cooperative green activity programs and the moderating impact of tourists' green trust in social media influencers.

Development of reed-based cellulose aerogel: a sustainable solution for crude oil spill clean-up.

This study focused on fabricating a cellulose aerogel for oil spill clean-up, using common reed () as the cellulose source. The process involved isolating cellulose from reed via traditional Kraft pulping, considering the effects of key factors on the isolated cellulose content. After a two-stage HP bleaching sequence, the highest cellulose content achieved was 27.

Some novel concepts of intuitionistic fuzzy directed graphs with application in selecting a suitable place for opening restaurant.

In this manuscript, we first initiate several types of effective arcs of intuitionistic fuzzy directed graphs, followed by discussions on different types of dominations in intuitionistic fuzzy directed graphs and their application in decision-making. The notion of dominations in fuzzy graphs, fuzzy directed graphs, intuitionistic fuzzy graphs and picture fuzzy graphs have been extensively discussed in the literature. Thus, the work presented in our study is two-fold: on one side, it extends the notion of domination in fuzzy directed graphs, while on the other side, it fills the gap existing in the literature.

Evaluating the GALAD Score for Detection of Hepatocellular Carcinoma in Patients With Cirrhosis.

Introduction: Early diagnosis of hepatocellular carcinoma (HCC) is crucial but challenging, and late detection limits its treatment and prognosis. We aimed to evaluate the GALAD score as a novel yet highly accurate and promising diagnostic tool for HCC.

Methods: A prospective and retrospective cohort study was conducted in 196 adult patients with cirrhosis, including 102 with HCC and 94 without.

Military influences on the evolution of clinical trials throughout history.

Clinical trials of drugs, procedures, and other therapies play a crucial role in advancing medical science by evaluating the safety, efficacy, and optimal use of medical interventions. The design and implementation of these trials have evolved significantly over time, reflecting advancements in medicine, ethics, and methodology. Early historical examples, such as King Nebuchadnezzar II's and his captives' dietary experiment and Ambroise Paré's treatment of gunshot wounds, laid some foundational principles of trial design.

Behavior modeling for a new flexure-based mechanism by Hunger Game Search and physics-guided artificial neural network.

Compliant mechanism has some advantages and has been widely applied in many accurate positioning systems. However, modeling the compliant mechanism behavior has suffered from many challenges, such as unstable results, and the limitation of training data set. In the field of compliant mechanism modeling, there has been no research interested in applying meta-heuristics optimization algorithms to optimize the weights and biases of the neural network globally.

Active Disturbance Rejection Control for an automotive suspension system based on parameter tuning using a fuzzy technique.

Road surface roughness is the cause of vehicle vibration, which is considered a system disturbance. Previous studies on suspension system control often ignore the influence of disturbances while designing the controller, leading to system performance degradation under severe vibration conditions. In this work, we propose a control method to improve active suspension performance that reduces vehicle vibration by eliminating the influence of road disturbances.

Partially unraveling mechanistic underpinning and weight loss effects of time-restricted eating across diverse adult populations: A systematic review and meta-analyses of prospective studies.

Time-restricted eating (TRE) is a promising and cost-effective dietary approach for weight management. This study aimed to evaluate the effects of TRE on weight loss in three adult populations using pre- and post-intervention analyses while also investigating its underlying mechanism. A systematic search was conducted across four databases (PubMed, Web of Science, Scopus, and the CENTRAL) up until January 28, 2024, specifically focusing on prospective studies that examined the efficacy of TRE in achieving weight loss.

Retroperitoneal ectopic pregnancy from a tertiary obstetrics hospital in Vietnam: A case series and literature review.

Retroperitoneal ectopic pregnancy is an uncommon condition in clinical practice, often associated with misdiagnosis and unconventional treatment. Delayed interventions can lead to poor prognosis and sometimes catastrophic situations. Due to the limited number of reported cases in the literature, an established treatment protocol has yet to be introduced.

The Indo-Burma biodiversity hotspot for ferns: Updated phylogeny, hidden diversity, and biogeography of the java fern genus (Polypodiaceae).

The Indo-Burma Biodiversity Hotspot is renowned for its rich biodiversity, including that of vascular plants. However, the fern diversity and its endemism in this hotspot have not been well understood and so far, the diversity of very few groups of ferns in this region has been explored using combined molecular and morphological approaches. Here, we updated the plastid phylogeny of the Java fern genus with 226 (115% increase of the latest sampling) samples across the distribution range, specifically those of three phylogenetically significant species, , .