Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders.

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the TGR5 receptor in the pathophysiology of psychiatric conditions, emphasizing their signaling within the gut-brain axis. We detail the synthesis and systemic functions of bile acids, their transformation by gut microbiota, and their impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety disorder, schizophrenia, autism spectrum disorder, and bipolar disorder.

National extension workshop: Connecting learners and educators to broaden reach and maximize impact in the 21st century.

Disseminating training nationwide through the Cooperative Extension Service, particularly as global demand for poultry products continues to increase, is critical for sustainable poultry production. Increasing urbanization, globalization of the poultry industry, consumer interest in animal welfare and labor shortages present opportunities for Extension professionals to engage diverse audiences and increase agricultural literacy. As part of the Poultry Science Association's 2024 National Extension Workshop, we presented examples of initiatives aimed at connecting educators, teachers and learners to address some of the pressing issues facing the poultry industry.

Can new-type infrastructure lead to regional green well-being? Evidence from China.

New-type infrastructure has an increasingly important role to play in realizing green well-being. By employing China's prefecture-level data from 2003 to 2021, we explore the influence of new-type infrastructure on green well-being and its impact mechanism. The results show that new-type infrastructure significantly improves regional green well-being (even under the presence of robustness tests and without policy intervention).

Unveiling the complexities of economic, development and governance factors in belt and road countries: A leap forward towards environmental management.

Ecological footprint (EF) is a useful tool for benchmarking environmental performance and monitoring progress toward a sustainable future. The influence of economic, developmental, and governance factors on EF poses a significant threat to ecological balance. However, existing studies have largely overlooked the interactive relationships among these factors and their impacts on the EF across different regions.

Occurrence and ecological risks of antibiotics and antiparasitics in surface water in urban lakes in Hanoi city, Vietnam.

The presence of antibiotics in the environment is of significant concern due to their adverse effects on aquatic ecosystems. This study provides an assessment of potential ecological risks (RQ) associated with the concentrations of eight antibiotics and antiparasitics (amoxicillin-AMO, azithromycin-AZI, ciprofloxacine-CIP, ofloxacine-OFL, oxfendazole-OXF, lincomycin-LIN, sulfacetamide-SCE and sulfamethoxazole-SME) in the surface water of 13 urban lakes in Hanoi city, Vietnam during the period 2021-2023. The findings revealed considerable variations in the total concentrations of these 8 substances (T), ranging from below the method detection limit (< MDL) to 2240 ng L with an average of 330.

Optimized fuzzy logic and sliding mode control for stability and disturbance rejection in rotary inverted pendulum.

This paper presents a novel and comprehensive control framework for the Rotary Inverted Pendulum (RIP), focusing on a hybrid control strategy that addresses the limitations of conventional methods in nonlinear and complex systems. The proposed controller synergistically combines an Optimized Fuzzy Logic Controller (OFLC) with Sliding Mode Control (SMC), leveraging the strengths of both techniques to achieve superior performance. The integration of Particle Swarm Optimization (PSO) into the OFLC significantly enhances its adaptability and precision, while the SMC law provides robust disturbance rejection and system stability.

Hybridisation of in silico and in vitro bioassays for studying the activation of Nrf2 by natural compounds.

Oxidative stress, characterized by the damaging accumulation of free radicals, is associated with various diseases, including cardiovascular, neurodegenerative, and metabolic disorders. The transcription factor Nrf2 is pivotal in cellular defense against oxidative stress by regulating genes that detoxify free radicals, thus maintaining redox homeostasis and preventing cellular aging. Keap1 plays a regulatory role through its interaction with Nrf2, ensuring Nrf2 degradation under homeostatic conditions and facilitating its stabilization and nuclear translocation during oxidative stress.

Influence of supporting teeth quantity of surgical guide on the accuracy of the immediate implant in the maxillary central incisor: an in vitro study.

Introduction: Guided surgery for immediate anterior implants aims to reduce the time required for aesthetic and functional immediate loading. However, the limited surface area of anterior teeth for guide stabilization may affect the accuracy of implant positioning. This in vitro study evaluated the effect of the number of supporting teeth on the accuracy of immediate implants in the maxillary central incisor region.

Economic evaluation of tenofovir disoproxil fumarate prophylaxis to prevent mother-to-child transmission of Hepatitis B virus infection: evidence from a lower-middle income country.

No cost-effectiveness information of preventive strategies for mother-to-child transmission (MTCT) of hepatitis B virus (HBV) has existed for policy decision making. This study aimed to compare the cost-effectiveness of alternative strategies to prevent MTCT of HBV in Vietnam. Cost-utility analysis using a hybrid decision-tree and Markov model were performed from healthcare system and societal perspectives.

Comparative analysis of the fit quality of monolithic zirconia veneers produced through traditional and digital workflows using silicone replica technique: an in vitro study.

Background: The success of a restoration largely depends on the quality of its fit. This study aimed to investigate the fit quality of monolithic zirconia veneers (MZVs) produced through traditional and digital workflows.

Methods: A typodont maxillary right central incisor was prepared.

Retraction notice to "Recent advancements of spinel ferrite based binary nanocomposite photocatalysts in wastewater treatment"[Chemosphere 274 (2021) 129734].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Social support status and associated factors among methadone maintenance patients: a multicentre, cross-sectional study in Vietnam during the COVID-19 pandemic.

Objectives: To investigate the social support status and associated factors among Vietnamese methadone maintenance patients during the COVID-19 pandemic.

Design: Cross-sectional study.

Setting: Three methadone clinics.

Anionic polysaccharides as delivery carriers for cancer therapy and theranostics: An overview of significance.

Recently, cancer therapy has witnessed remarkable advancements with a growing focus on precision medicine and targeted drug delivery strategies. The application of anionic polysaccharides has gained traction in various drug delivery systems. Anionic polysaccharides have emerged as promising delivery carriers in cancer therapy and theranostics, offering numerous advantages such as biocompatibility, low toxicity, and the ability to encapsulate and deliver therapeutic agents to tumor sites with high specificity.

Psychometric evaluation of the elderly mobility scale in Indonesia.

Background: The Elderly Mobility Scale (EMS) is widely used to identify mobility limitations in older adults, though it has not been validated in Indonesia.

Aim: To evaluate the reliability and validity of the Indonesian version of the EMS (EMS-I).

Method: A cross-sectional design involving 230 older adults in South Tangerang City, Indonesia, was used.

Functional outcome of multiple toe transfer procedure for open multiple transmetacarpal amputation secondary to a crushing injury: A case report.

Introduction: Reconstruction for open multiple transmetacarpal amputation secondary to a crushing injury is really challenging. Some treatment approaches could be proposed. To avoid the drawbacks of a prosthesis and hand transplantation such as the high cost, and long-term side effects of anti-rejection drugs, toe transfers were chosen.

Genomic analysis and virulence of human Streptococcus suis serotype 14.

Purpose: Streptococcus suis serotype 14 is the second most prevalent serotype being highly prevalent in Southeast Asia. This study aimed to characterize genetic background, population structure, virulent genes, antimicrobial-resistant genes, and virulence of human S. suis serotype 14.

A systematic review on ethnobotany, phytochemistry, and pharmacology of R. Br. (Boraginaceae), a medicinal plant.

For the first time, critical review on R. Br. (Boraginaceae) is established.

Leaf Na+ effects and multi-trait GWAS point to salt exclusion as the key mechanism for reproductive stage salinity tolerance in rice.

Background And Aims: Since salinity stress may occur across stages of rice (Oryza sativa L.) crop growth, understanding the effects of salinity at reproductive stage is important although it has been much less studied than at seedling stage.

Methods: In this study, lines from the Rice Diversity Panel 1 (RDP1) and the 3000 Rice Genomes (3KRG) were used to screen morphological and physiological traits, map loci controlling salinity tolerance through genome-wide association studies (GWAS), and identify favorable haplotypes associated with reproductive stage salinity tolerance.

A happy place to be in: how beliefs about living places influence depression in Chinese international student returnees.

Background: The mental health of Chinese international student returnees is a critical concern impacting their well-being and successful reintegration into home society, especially in the post-COVID-19 era. This study examines how beliefs about changing living conditions, emigration intentions, and belief in fate influence depression levels among these returnees.

Methods: A cross-sectional survey collected data from 1,014 returnees through WeChat public groups.

Chatbots for breast cancer education: a systematic review and meta-analysis.

Background: Effective education and awareness regarding breast cancer are critical. Traditional educational methods often fail to meet the diverse information needs of patients. Patients should be provided with tailored, accessible information to improve their retention and understanding of disease-related information.

Ecological and anthropogenic effects on the genomic diversity of lemurs in Madagascar.

Ecological variation and anthropogenic landscape modification have had key roles in the diversification and extinction of mammals in Madagascar. Lemurs represent a radiation with more than 100 species, constituting roughly one-fifth of the primate order. Almost all species of lemurs are threatened with extinction, but little is known about their genetic diversity and demographic history.

Investigating steeply inclined abandoned mines for unlocking the secrets of water level recovery.

With the growing emphasis on environmental protection, many coal mines in northern China were closed. However, the cessation of pumping operations in those closed mines has caused a rise in groundwater levels, giving rise to various safety and environmental concerns. Understanding the patterns of water level recovery is vital for effectively managing abandoned mine sites and ensuring the uninterrupted production of adjacent coal mines.

Review of mercury pollution research in Southeast Asian marine environments.

Mercury (Hg) is a global pollutant of widespread concern, and modern Hg levels have been much elevated compared to pre-industrial levels. The majority of environmental Hg assessment has occurred in the developed world within the temperate region, but recent years we have witnessed increases in research activities in polar, subtropical, and tropical biomes. East Asia is currently the biggest emitter of anthropogenic Hg, while intense research is ongoing in China, Korea, and Japan, relatively little has been done in the neighboring regions.