DIKOApp: An AI-Based Diagnostic System for Knee Osteoarthritis.

The diagnosis of knee osteoarthritis is challenging due to its complex nature and various contributing factors. With the advancement of artificial intelligence (AI) technology, some computer vision-based methods have been developed to address this task. However, when applied in practice, these methods encounter numerous challenges.

Antioxidative and mineral-binding food-derived peptides: Production, functions, metal complexation conditions, and digestive fate.

The discovery of food-derived biopeptides is becoming increasingly prevalent in the scientific community. Some peptides possess multiple biological functions that can confer health benefits through various mechanisms following ingestion. The present review targets food-derived antioxidant and mineral-binding peptides (AMBPs) including their production procedure i.

Stroke Epidemiology in Asia.

Background Stroke is a major cause of death and disability globally, with different stroke burdens in different regions. This paper reviews the epidemiology of stroke in Asia. Summary There is a wide range in age and sex-standardised stroke incidence, highest in China, lowest in Bhutan.

Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids.

We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.

Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study.

Background: Turmeric and boswellia supplements have gained popularity for their anti-inflammatory and antioxidant properties. It is important to critically assess the safety of such supplements for prolonged use.

Objectives: To assess the safety and tolerability of turmeric-boswellia-sesame oil formulation (TBSF) in healthy human volunteers.

Improving the Prioritization of Heart Transplantation Candidates for Optimal Clinical Outcomes: A Narrative Review.

Purpose Of Review: This narrative review evaluates the limitations of current heart transplantation allocation models, which prioritize medical urgency and waitlist time but fail to adequately predict long-term post-transplant outcomes. It aims to identify advanced metrics that can strengthen the prioritization framework while addressing persistent racial, geographic, and socioeconomic inequities in access to transplantation.

Recent Findings: Recent research indicates that incorporating frailty, nutritional status, immunological compatibility, and pulmonary hemodynamics into allocation frameworks can enhance the prediction of transplant outcomes.

 (Rubiaceae, Ophiorrhizeae), a new species from Vietnam.

is described as a new species endemic to Central Vietnam. It is morphologically closest to in having setose hairs on the abaxial leaf surface and a pedunculate head-like inflorescence but differs from the latter by a number of characteristics: shorter stem, 3-lobed stipules, narrowly lanceolate leaf blades with a cuneate-oblique base and 20-22 pairs of secondary veins, 3.5-4.

Efficient counter electrode for quantum dot sensitized solar cells using p-type PbS@reduced graphene oxide composite.

This study developed a novel PbS-rGO composite counter electrode to enhance the performance of quantum dot-sensitized solar cells (QDSSCs). The composite was synthesized a hydrothermal method by anchoring PbS nanocubes onto reduced graphene oxide (rGO) sheets. The effect of the mass ratio of rGO to PbS (0.

Identifying fecal microbiota signatures of colorectal cancer in a Vietnamese cohort.

Background: Colorectal cancer (CRC) is among the top three causes of global cancer mortality. In Vietnam, CRC is the third leading cause of death in women and the fourth cause of cancer mortality in men. A large number of metagenomic studies have reported the relationship between altered composition and function of the gut microbiota with CRC, but this relationship in low- and middle-income countries including Vietnam (with an estimated population of 100.

Comparative phenotypic and proteomic analysis of colistin-exposed .

Introduction: The emergence of colistin resistance threatens the treatment of infections.

Methods: In this study, in vitro development of colistin resistance was investigated using comparative phenotypic and proteomic analysis of ATCC 9027, its 14-day colistin sub-MIC exposed strain (Col-E1), and 10-day antibiotic-free cultured Col-E1 strain (Col-E2). Antibiotic susceptibility, morphology, virulence factors, and proteomic changes were assessed using disc-diffusion, agar-based, spectrophotometry, SEM, and iTRAQ-LC-MS/MS methods.

Syntheses, structures and anti-cancer activities of Cu and Zn complexes containing 1,1'-[(3-fluoro-phen-yl)methyl-ene]bis-[3-(3-fluoro-phen-yl)imidazo[1,5-]pyridine].

Two novel complexes, [Cu()Cl] and [Zn()Cl], were synthesized from 1,1'-[(3-fluoro-phen-yl)methyl-ene]bis-[3-(3-fluoro-phen-yl)imidazo[1,5-]pyridine] (), and copper(II) and zinc(II) chloride, respectively. The structures of these complexes were confirmed using ESI-MS, IR and H NMR spectra. The results reveal mononuclear structures in which the central metal atoms are coordinated by two N atoms from the imidazole rings and two Cl ligands.

The first mitogenome report of Zimmer 1921 (Malacostraca: Cumacea).

In 1921, Zimmer established the genus for from Japanese waters. This study determined the first complete mitogenome of hooded shrimp sequenced from (Cumacea: Diastylidae). is a type species of the genus , distributed in the West Pacific from southern Kuril to Vietnam, including Korean waters.

A Topology-Enhanced Multi-Viewed Contrastive Approach for Molecular Graph Representation Learning and Classification.

In recent times, graph representation learning has been becoming a hot research topic which has attracted a lot of attention from researchers. Graph embeddings have diverse applications across fields such as information and social network analysis, bioinformatics and cheminformatics, natural language processing (NLP), and recommendation systems. Among the advanced deep learning (DL) based architectures used in graph representation learning, graph neural networks (GNNs) have emerged as the dominant and highly effective framework.

Full-arch implant-supported rehabilitation using reverse scan technique: A case report.

The reverse scan technique offers several advantages, such as improvements of accuracy and visibility of critical anatomical structures, minimizing chair time, and providing better patient comfort. This was a case report successfully employing the reverse scan technique. A 72-year-old male patient desired to restore his teeth in both jaws, as he experienced difficulty eating and had never worn dentures.

Molecular detection of the zoonotic trematode Centrocestus formosanus (Nishigori, 1924) (Opisthorchiida, Heterophyidae) in Central Europe.

In our study, fancy southern platyfish Xiphophorus maculatus (Cyprinodontiformes, Poeciliidae) were examined due to breathing disorders and mortality. Fish came from Vietnam farm and were redistributed by international wholesaler. In fish, loss of appetite and gasping near the water surface was observed.

An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers.

The autonomous and active Long-Interspersed Element-1 (LINE-1, L1) and the non-autonomous Alu retrotransposon elements, contributing to 30% of the human genome, are the most abundant repeated sequences. With more than 90% of their sequences being methylated in normal cells, these elements undeniably contribute to the global DNA methylation level and constitute a major part of circulating-cell-free DNA (cfDNA). So far, the hypomethylation status of LINE-1 and Alu in cellular and extracellular DNA has long been considered a prevailing hallmark of ageing-related diseases and cancer.

Hypermethylation at 45S rDNA promoter in cancers.

The ribosomal genes (rDNA genes) encode 47S rRNA which accounts for up to 80% of all cellular RNA. At any given time, no more than 50% of rDNA genes are actively transcribed, and the other half is silent by forming heterochromatin structures through DNA methylation. In cancer cells, upregulation of ribosome biogenesis has been recognized as a hallmark feature, thus, the reduced methylation of rDNA promoter has been thought to support conformational changes of chromatin accessibility and the subsequent increase in rDNA transcription.

Assessing the Feasibility and Diagnostic Value of Percutaneous Transhepatic Cholangioscopy Biopsy for Biliary Strictures.

Objective: To evaluate the feasibility and diagnostic value of percutaneous transhepatic cholangioscopy biopsy (PTCB) for identifying the causes of biliary strictures.

Methods: This retrospective study included 34 patients (18 females and 16 males), with a mean age of 59.4 ± 13 years.

Predictors of Palliative Care Self-efficacy Among Health Care Professionals in Vietnam: A Cross-sectional Study.

This study aimed to investigate predictors of palliative care self-efficacy among Vietnamese health care professionals. An online descriptive cross-sectional survey was conducted at 1 hospital in Vietnam. Participants completed survey questionnaires including demographics, professional experience, Palliative Care Self-Efficacy, Palliative Care Quiz for Nursing, Frommelt Attitudes Toward Care of the Dying-Form B, Santa Clara Brief Compassion Scale, and Self-Compassion Scale-Short Form.

Speciation and historical invasions of the Asian black-spined toad (Duttaphrynus melanostictus).

Animal translocations provide striking examples of the human footprint on biodiversity. Combining continental-wide genomic and DNA-barcoding analyses, we reconstructed the historical biogeography of the Asian black-spined toad (Duttaphrynus melanostictus), a toxic commensal amphibian that currently threatens two biodiversity hotspots through biological invasions (Wallacea and Madagascar). The results emphasize a complex diversification shaped by speciation and mitochondrial introgression that comprises two distinct species.

The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepatoblastoma.

Background: Hepatoblastoma (HB) is the most common malignant solid tumor of the liver in children and is a fatal disease with a poor prognosis. Therefore, indicators that can be used for the early prediction of the HB prognosis are necessary. Sodium glucose cotransporter 2 (SGLT2) is a glucose transporter protein present in the proximal renal tubules.

Global Challenges in the Access of Endovascular Treatment for Acute Ischemic Stroke (Global MT Access).

Background: Mechanical thrombectomy (MT) is the standard of care for eligible acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) since 2015.

Aim: Our aim was to determine the key challenges for MT implementation and access worldwide.

Methods: We conducted an international online survey consisting of 37 questions, distributed through the World Stroke Organization network, and as invited by co-authors between December 2022 and March 2023.

Hepatitis C Virus-Core Antigen: Implications in Diagnostic, Treatment Monitoring and Clinical Outcomes.

The hepatitis C virus (HCV) infection, a global health concern, can lead to chronic liver disease. The HCV core antigen (HCVcAg), a viral protein essential for replication, offers a cost-effective alternative to HCV RNA testing, particularly in resource-limited settings. This review explores the significance of HCVcAg, a key protein in the hepatitis C virus, examining its structure, function, and role in the viral life cycle.