A death involving probenecid.

A death following deliberate ingestion of approximately 75 g of probenecid in a 36-year-old man is described. Tissue concentrations of probenecid were highest in serum (710 mg/L) and liver (550 mg/kg). Probenecid was also detected in vitreous and bile.

Melatonin, cortisol and prolactin response to acute nocturnal light exposure in healthy volunteers.

An investigation of the cortisol and prolactin responses accompanying acute melatonin suppression by light (600 lux) in humans is described. Light given from midnight to 0300h suppressed nocturnal plasma melatonin concentrations by 65%. Despite this significant suppression of melatonin, no significant effect on plasma cortisol or prolactin concentrations was observed.

Purification of human leucocyte DNA: proteinase K is not necessary.

A rapid nontoxic method for the purification of DNA from human leucocytes is described. Preliminary experiments which tested different methods of DNA purification indicated that digestion of proteins with proteinase K was unnecessary. This led to the development of a simple procedure involving lysis of the cells in SDS followed by extraction with 6 M NaCl.

An unusual injury.

The case of a young man who died unexpectedly from myocarditis is presented. The body was partially embalmed before autopsy at the Victorian Institute of Forensic Pathology. Although the cause of death was not a problem to diagnose, this case highlights artefacts that embalming may cause and the difficulties it may create with interpretation of injury.

An unusual case of comingled remains.

Two motor cyclists were involved in a head-on collision. One of the motor cyclists sustained a stab wound to the chest by a portion of long bone derived from the other motor cyclist. This case is reported because of its unusual nature.

The cervical spine in fatal motor vehicle accidents.

Of 100 fatal accident cases involving motor vehicles, 60 showed damage to the cervical spine, involving bony or disc damage in 31 and focal haemorrhages in another 29. In 8 cases, pre-autopsy radiology failed to detect lesions which were found by radiology and pathological examination of the post-autopsy specimen. Most of the lesions missed were at the C6-7 region.

The Royal Commission into Aboriginal Deaths in Custody. Aspects of medical interest.

The Royal Commission into Aboriginal Deaths in Custody was established in a climate of deep suspicion about the treatment of Aboriginal detainees in Australian prisons and police lock-ups. Three and a half years of exhaustive enquiry have resulted in a mammoth report which not only deals with the problems in the criminal justice system that contribute to these deaths but also discusses in detail the current state of Aboriginal society in Australia. It is the Commission's view that improvements in the lives of Aboriginal people will only occur if they are given the power to bring about those improvements themselves.

Urinary 6-sulphatoxy melatonin levels within the menstrual cycle and in patients with premenstrual syndrome.

The present investigation examined the production of urinary 6-sulphatoxy melatonin (aMT.6S) during the early follicular and late luteal (premenstrual) phases in healthy, normal women and in patients with premenstrual syndrome (PMS). There was no significant difference in levels of aMT.