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Distinguishing recurrence from radiation-induced lung injury at the time of RECIST progressive disease on post-SABR CT scans using radiomics.

Sci Rep

February 2024

Baines Imaging Research Laboratory, London Regional Cancer Program, London Health Sciences Centre, Victoria Hospital (A3-123A), 800 Commissioners Rd E, London, ON, N6A 5W9, Canada.

Stereotactic ablative radiotherapy (SABR) is a highly effective treatment for patients with early-stage lung cancer who are inoperable. However, SABR causes benign radiation-induced lung injury (RILI) which appears as lesion growth on follow-up CT scans. This triggers the standard definition of progressive disease, yet cancer recurrence is not usually present, and distinguishing RILI from recurrence when a lesion appears to grow in size is critical but challenging.

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