Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing.

Objective: Evaluate a precision medicine approach to confirm a tentative diagnosis of fatal malignant hyperthermia (MH) in isoflurane-anesthetized pet dogs by identifying novel risk variants in known MH susceptibility genes.

Study Design: Retrospective case series.

Animals: A male Pit Bull mix aged 7 years (case #1), a male Golden Retriever aged 12 months (case #2) and the dam and sire of case #2.

Corpus Callosum Abnormality in a Free-Ranging Coyote (Canis latrans).

A juvenile coyote (Canis latrans) was presented to a wildlife rehabilitation center with intermittent circling, hypernatremia, and elevated blood urea nitrogen. Diagnostic testing supported a diagnosis of hypodipsic hypernatremia. Postmortem magnetic resonance imaging (MRI) and necropsy revealed marked hypoplasia of the corpus callosum, a finding not previously reported in a free-ranging animal.

A lateral approach allows accurate and stable total elbow replacement in dogs.

Objective: Evaluate whether total elbow replacement (TER) through a lateral approach is accurate and stable.

Animals: 12 skeletally mature large-breed dog cadavers were used.

Methods: Limb alignment, elbow joint motion, and collateral ligament laxity were evaluated preoperatively.

Systematic review of postoperative rehabilitation interventions after cranial cruciate ligament surgery in dogs.

Objective: To critically evaluate the evidence for rehabilitation interventions following surgery for cranial cruciate ligament disease (CCLD) in dogs.

Study Design: Systematic review.

Methods: Google Scholar and Pubmed databases were searched for studies evaluating postoperative CCLD rehabilitation interventions from 1990 until March 2020 per the international Prospective Register of Systematic Reviews (PROSPERO).

Computed Tomography of the Mandibles of a Stranded Offshore Killer Whale (Orcinus orca).

A mature, adult female, offshore killer whale (Orcinus orca) was stranded deceased in Portage Bay, Alaska, in October 2015. Full necropsy examination with histopathology was performed. Consistent with previous studies of offshore killer whales, and thought to be a result of their unique elasmobranch diet, all the teeth were significantly abraded and almost flush with the gingival margin.

Surgical decompression, with or without adjunctive therapy, for palliative treatment of primary vertebral osteosarcoma in dogs.

Vertebral osteosarcoma (OSA) is the most common primary vertebral tumor in dogs, however studies examining the survival time after surgical decompression of these tumors are limited. There is also limited information regarding the benefit of adjunctive treatments such as radiation therapy or chemotherapy in these patients. The goal of this study was to determine survival time of dogs with primary vertebral OSA after palliative decompressive surgery alone and combined with radiation therapy and/or chemotherapy.

Canine spinal meningiomas and nerve sheath tumours in 34 dogs (2008-2016): Distribution and long-term outcome based upon histopathology and treatment modality.

The purpose of this retrospective, multicentre case series was to describe the outcome following surgery and/or radiation of spinal meningiomas and nerve sheath tumours (NSTs) based upon treatment modality, with a specific aim to evaluate the survival times and time to recurrence following treatment for each histopathological diagnosis. Our hypothesis was that the addition of radiation therapy modalities to treatment will yield longer time to recurrence of clinical signs and survival time. Thirty-four dogs met the inclusion criteria of histopathologically diagnosed extramedullary spinal meningioma or NST.

Conjoined Fetal Twins in a Harbor Seal (Phoca vitulina).

In July 2013, a stranded harbor seal (Phoca vitulina) died giving birth to conjoined fetuses. The twins were joined at the abdomen and thoracolumbar spine with the vertebral axis at 180°. The cause of this unique anomaly--a first for this species--was not identified.

Rostral maxillectomy and radiation therapy to manage squamous cell carcinoma in a ferret.

A 4-year-old, male, neutered ferret presented with squamous cell carcinoma of the right maxillary region associated with the tissues surrounding the upper canine tooth. A rostral maxillectomy was performed to excise the mass. Histopathologic examination showed questionable margins of tumor removal.