3 results match your criteria: "Veterans Affairs Medical Center and University of California School of Medicine[Affiliation]"
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines.
Int J Cancer
August 2008
Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA.
Secreted frizzled-related protein 2 (sFRP2) is a negative modulator of the Wingless-type (Wnt) signaling pathway, and shown to be inactivated in renal cell carcinoma (RCC). However, the molecular mechanism of silencing of sFRP2 is not fully understood. Our study was designed to elucidate the silencing mechanism of sFRP2 in RCC.
View Article and Find Full Text PDFEpigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer.
Clin Cancer Res
May 2007
Department of Urology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, California 94121, USA.
Purpose: The RAS-association domain family 1, isoform A (RASSF1A) gene is shown to be inactivated in prostate cancers. However, the molecular mechanism of silencing of the RASSFIA gene is not fully understood. The present study was designed to investigate the mechanisms of inactivation of the RASSF1A gene through the analysis of CpG methylation and histone acetylation and H3 methylation associated with the RASSF1A promoter region.
View Article and Find Full Text PDFVirtual colonoscopy (CT and MR colonography).
Gastrointest Endosc
June 2002
Department of Radiology, Veterans Affairs Medical Center and University of California School of Medicine, San Francisco, California 94121, USA.