2 results match your criteria: "Veteran Administration University of California Irvine Medical Center[Affiliation]"
W-Compound can be used as a Biomarker for Fetal Thyroid Function and a Potential Tool for Screening Congenital Hypothyroidism.
Endocrinol Disord
June 2022
Department of Research, Veteran Administration University of California Irvine Medical Center, Long Beach, CA 90822.
Sulfoconjugation is the major pathway for thyroid hormone (TH) metabolism, converting T4 to inactive metabolites, T4S, rT3S, and T3S in fetus, via sulfotransferases (SULT) and type 3 deiodinase in gestation. Consistent with high production rate of T4S and rT3S, there are high serum sulfated iodothyronine analogs, including T4S, T3S, rT3S, and 3,3'-T2S (T2S), in ovine and human fetal and preterm infants. Fetal TH metabolic pathways predict T2S as the major TH metabolite in the fetus.
View Article and Find Full Text PDFMaternal 3,3'-Diiodothyronine Sulfate Formation from Guinea Pig Placenta Perfused with 3,3',5-Triodothyronine.
Endocrinol Disord
September 2021
Department of Obstetrics and Gynecology, University of California Irvine, Irvine, CA 92697.
Article Synopsis
- The study explores how the placenta affects the metabolism of 3, 3',5-triiodothyronine (T) during late-stage pregnancy in guinea pigs, which reflects similar processes in humans.
- In experiments, researchers found that sulfated 3, 3'-diiodothyronine (TS), a metabolite of T, was transferred from the fetus to the mother, indicating the placenta's crucial role in regulating fetal T levels.
- The findings suggest that specific enzymes in the placenta help protect the developing fetus from excess active thyroid hormone and that TS could be a valuable biomarker for assessing fetal thyroid function in future studies.