2,467 results match your criteria: "Verrucous Carcinoma"
Verrucous gastritis-like lesion in intramucosal Helicobacter pylori-uninfected signet ring cell carcinoma with poorly differentiated adenocarcinoma.
Clin J Gastroenterol
June 2024
Department of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8553, Japan.
In Japan, accessible Helicobacter pylori (Hp) eradication therapy is associated with an increase in the prevalence of gastric cancers (GCs) in Hp uninfected stomachs. Signet ring cell carcinoma (SRCC) is the most common of these GCs. Intramucosal SRCC with poorly differentiated adenocarcinoma (PDA) occurring in Hp uninfected gastric mucosa is rare; furthermore, many Hp uninfected pure SRCCs exhibit discoloration and flat or slightly depressed lesions, and morphological elevation is relatively rare.
View Article and Find Full Text PDFVulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
J Natl Compr Canc Netw
March 2024
National Comprehensive Cancer Network.
Article Synopsis
- Vulvar cancer is diagnosed in about 6,470 individuals each year, primarily as squamous cell carcinomas, constituting 5% to 8% of gynecologic cancers.
- Key risk factors include older age, HPV infection, smoking, inflammatory vulvar conditions, and weakened immune systems.
- The text reviews NCCN Clinical Practice Guidelines for treatments, surveillance, systemic therapies, and survivorship for those affected by vulvar cancer.
Management and treatment of four cases of oral carcinoma cuniculatum.
J Korean Assoc Oral Maxillofac Surg
February 2024
Department of Oral and Maxillofacial Surgery, KAT General Hospital of Attica, Athens, Greece.
Objectives: Oral carcinoma cuniculatum (OCC) is a rare variant of squamous cell carcinoma (SCC). It has similar clinicopathological characteristics to SCC and verrucous carcinoma (VC). We present a case series of OCC and analyse its unique features, diagnosis, and management.
View Article and Find Full Text PDFGlobal gene expression profile of proliferative verrucous leukoplakia and its underlying biological disease mechanisms.
Oral Oncol
April 2024
Australian Centre for Oral Oncology Research & Education, Nedlands, WA, Australia; UWA Dental School, University of Western Australia, Nedlands, WA, Australia. Electronic address:
Article Synopsis
- Proliferative verrucous leukoplakia (PVL) is a rare oral disorder that often leads to squamous cell carcinoma, and this study aimed to identify gene expression patterns in PVL to find potential biomarkers and understand its molecular causes.
- The researchers analyzed biopsies from 32 patients with either PVL or non-PVL oral leukoplakia using RNA sequencing, revealing significant differences in gene expression with 464 genes varying at least 2-fold between the groups.
- The findings indicate that PVL has a distinct molecular profile with overexpression of cancer-related genes and reduced fibroblast markers, suggesting that biomarker-based molecular diagnostics can help differentiate PVL from other oral lesions and improve treatment approaches.*
Proliferative verrucous leukoplakia: Report of a case and literature review.
Oral Oncol
March 2024
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430079 Wuhan, China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 430079 Wuhan, China. Electronic address:
Well-differentiated Squamous Cell Carcinoma With Sarcomatous Differentiation in Patient With a History of Recurrent Verrucous Carcinoma.
Int J Gynecol Pathol
March 2024
Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri.
Human papillomavirus-independent vulvar squamous cell carcinoma has a peak incidence in about the eighth decade of life. A variable portion of the vulvar squamous cell carcinoma are human papillomavirus-independent comprising 20% to 80% of all cases. Verrucous carcinoma (VC) is part of the spectrum of human papillomavirus-independent carcinomas and its combination with well-differentiated squamous cell carcinoma with sarcomatous differentiation is an extremely unusual neoplasm.
View Article and Find Full Text PDFPorocarcinoma in a palm reconstructed with a full thickness skin graft: A case report.
World J Clin Cases
January 2024
Department of Plastic and Reconstructive Surgery, Konyang University Medical Center, Konyang University of College of Medicine, Daejeon 35365, South Korea.
Background: Porocarcinoma is a rare type of skin cancer that originates from sweat gland tumors. It is an aggressive malignant skin cancer that is difficult to diagnose clinically owing to its rarity and similarity to squamous cell carcinoma (SCC).
Case Summary: This case involved a 92-year-old woman, a farmer by profession, presented with an exophytic and verrucous mass on her left palm that had formed 2 years prior and caused chronic pain and frequent bleeding.
Human antigen R knockdown attenuates the invasive activity of oral cancer cells through inactivation of matrix metalloproteinase-1 gene expression.
J Dent Sci
January 2024
Department of Vascular Biology and Molecular Pathology, Division of Oral Pathobiological Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan.
Article Synopsis
- The study investigates the role of the RNA-binding protein HuR in enhancing the invasive activity of oral carcinoma cells by analyzing its expression and function.
- Researchers used various techniques, including proliferation assays and immunohistochemistry, to demonstrate that knocking down HuR significantly reduces the invasion of cancer cells.
- Results indicate that HuR promotes the expression of matrix metalloproteinase-1 (MMP-1), which is associated with cancer invasiveness, suggesting that targeting HuR may be a potential strategy for limiting cancer spread.
Molecular landscape of proliferative verrucous leukoplakia: a systematic review.
Br J Oral Maxillofac Surg
February 2024
Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Institute for Life Sciences, University of Southampton, Southampton, UK.
Article Synopsis
- Proliferative verrucous leukoplakia (PVL) is a rare oral condition with a potential to evolve into oral cancers, lacking predictive biomarkers for its progression.
- A review of 685 cases revealed PVL’s genomic profile includes initial high loss of heterozygosity (LOH) and low copy number alterations, with later mutations found in specific genes but no TP53 mutations.
- Differences in LOH and specific chromosomal deletions and amplifications suggest similarities with oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC), indicating a need for further research to clarify PVL's genomic landscape.
Pedunculated Verrucous Tumor on the Buttock.
Cutis
December 2023
Brittany L. Berlin and Dr. Sarro are from Florida Atlantic University, Boca Raton. Dr. Rosen is from and Dr. Sarro also is from Premier Dermatology Partners, Boca Raton.
Multiple verrucous squamous cell carcinomas developing on chronic hidradenitis suppurativa lesions-a rare case report from Romania.
Front Med (Lausanne)
January 2024
Department of Dermatology, Dermatology Clinic, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Article Synopsis
Verrucous Plaques in a Young Woman: Challenge.
Am J Dermatopathol
February 2024
Department of Anatomic Pathology, Corewell Health East, Royal Oak, MI.
Verrucous Plaques in a Young Woman: Answer.
Am J Dermatopathol
February 2024
Department of Anatomic Pathology, Corewell Health East, Royal Oak, MI.
Successful application of aminolevulinic acid/photodynamic therapy in the treatment of giant condyloma acuminatum in an 87-year-old patient.
Photodiagnosis Photodyn Ther
February 2024
The First Affiliated Hospital of Zhengzhou University in China, No.1 East Road, Zhengzhou, Henan, China.
Article Synopsis
- Condyloma acuminatum is a common sexually transmitted infection caused by the human papillomavirus, leading to warts in the genital and perianal areas.
- Traditional treatments for this condition include methods like laser therapy and freezing, but they often come with downsides such as pain and high chances of recurrence.
- A recent case demonstrated successful treatment of an 87-year-old patient with ALA-PDT (Aminolevulinic acid/photodynamic therapy), achieving effective results without recurrence over six months, suggesting ALA-PDT should be more widely used.
Case report: Buschke-Lowenstein tumor, a giant anal condyloma acuminata.
Cir Cir
December 2023
Departamento de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
Article Synopsis
- A 24-year-old man, who is HIV positive, presented with a large, painful anal condyloma that showed signs of infection.
- Pathology results indicated the presence of in situ squamous cell carcinoma within the condyloma.
- The findings revealed that the lesion was a Buschke-Lowenstein tumor, a type of giant condyloma associated with HPV.
Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
J Otolaryngol Head Neck Surg
December 2023
Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
Objective: To investigate epidemiological, clinical and oncological outcomes of patients with laryngeal verrucous carcinomas (LVC).
Methods: Two independent authors investigated PubMed, Scopus and Cochrane Library for studies dedicated to epidemiological, clinical and oncological outcomes of patients with LVC. The following outcomes were investigated with PRISMA criteria: age; gender; tobacco/alcohol consumption; HPV infection; anatomical, pathological, therapeutic and survival outcomes.
A case of Kaposi sarcoma arising from giant condyloma acuminatum.
Asian J Surg
March 2024
Department of Colorectal Surgery, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. Electronic address:
Widespread Verrucous Plaques: Challenge.
Am J Dermatopathol
January 2024
Department of Dermatology, Baylor College of Medicine, Houston, TX.
Widespread Verrucous Plaques: Answer.
Am J Dermatopathol
January 2024
Department of Dermatology, Baylor College of Medicine, Houston, TX.
Cornu Cutaneum: Case Reports of Patients With a Cutaneous Horn Associated With Either a Verruca Vulgaris or an Inverted Follicular Keratosis and a Review of the Etiologies of Cutaneous Horns.
Cureus
October 2023
Dermatology, Davis Medical Center, University of California, Sacramento, USA.
Article Synopsis
- A cutaneous horn, or cornu cutaneum, is a growth made of keratinizing skin cells that often develops over underlying skin lesions such as benign and malignant tumors, infections, or other skin conditions.
- The text describes two cases: a 22-year-old woman with a cutaneous horn linked to a stubborn wart on her toe, and a 57-year-old man with a horn associated with inverted follicular keratosis on his lip.
- The most common conditions related to cutaneous horns are actinic keratosis, squamous cell carcinoma, and seborrheic keratosis, with several benign and malignant tumors associated with these skin growths.
Proliferative verrucous leukoplakia/multifocal leukoplakia in patients with and without oral submucous fibrosis.
Med Oral Patol Oral Cir Bucal
January 2024
King's College London Bessemer, Rd, SE 5 9RA, London
Article Synopsis
- - The study examines a rare case series of patients with multifocal leukoplakia, focusing on those with and without oral submucous fibrosis (OSF), to explore the clinical behaviors and management challenges associated with these potentially malignant disorders.
- - Researchers analyzed data from six Indian patients over a span of 5.5 to 13 years, recording various clinical details and implementing treatments like metronomic therapy when surgical options failed.
- - Findings reveal that all patients eventually developed proliferative verrucous leukoplakia (PVL) following initial diagnoses, leading to multiple recurrences and complications, highlighting the need for more clinical trials on metronomic therapy for aggressive cases.
Verrucous Plaque on the Foot.
Cutis
October 2023
Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University, China.
Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial.
JAMA Oncol
January 2024
Division of Oral Medicine and Dentistry, Dana-Farber Cancer Institute and Brigham & Women's Hospital, Boston, Massachusetts.
Article Synopsis
- - Proliferative verrucous leukoplakia (PVL) is a serious oral condition with a high chance of becoming invasive cancer, and there's currently no effective treatment. Recent findings point to a strong immune presence in PVL, leading researchers to explore immune checkpoint therapy as a potential treatment option.
- - This study aimed to assess the safety and effectiveness of anti-PD-1 therapy (nivolumab) for treating high-risk PVL in a phase 2 clinical trial with 33 participants, monitored over about 21 months.
- - Results showed that 36% of patients experienced a significant reduction in their condition, while some faced worsening disease; researchers also looked at immune responses and genetic factors as part of the treatment
Proliferative verrucous leukoplakia: a case report of multiple metachronous oral verrucous carcinoma.
BMJ Case Rep
November 2023
Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche, Universita' degli Studi di Milano, Milan, Italy.
Article Synopsis
- Proliferative verrucous leukoplakia (PVL) is a unique and progressive type of oral leukoplakia that doesn’t correlate with common risk factors like smoking or drinking.
- Patients with PVL have a significantly high chance of developing oral squamous cell carcinoma.
- A case study highlighted a PVL patient who developed two separate oral verrucous carcinomas, underscoring the need for ongoing clinical and histopathological monitoring throughout their life.